A search for the decay modes B+/- to h+/- tau l

We present a search for the lepton flavor violating decay modes B+/- to h+/- tau l (h= K,pi; l= e,mu) using the BaBar data sample, which corresponds to 472 million BBbar pairs. The search uses events where one B meson is fully reconstructed in one of several hadronic final states. Using the momenta of the reconstructed B, h, and l candidates, we are able to fully determine the tau four-momentum. The resulting tau candidate mass is our main discriminant against combinatorial background. We see no evidence for B+/- to h+/- tau l decays and set a 90% confidence level upper limit on each branching fraction at the level of a few times 10^-5.Comment: 15 pages, 7 figures, submitted to Phys. Rev.

Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw.

The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their initial origins to their final destinations and imbue their derivatives with aspects of form including their axial orientation, anatomical identity, size, and shape. Perturbations along the way can produce defects and disease, but also generate the variation necessary for jaw evolution and adaptation. We focus on molecular and cellular mechanisms that regulate form in the amniote jaw complex, and that enable structural and functional integration. Special emphasis is placed on the role of cranial neural crest mesenchyme (NCM) during the species-specific patterning of bone, cartilage, tendon, muscle, and other jaw tissues. We also address the effects of biomechanical forces during jaw development and discuss ways in which certain molecular and cellular responses add adaptive and evolutionary plasticity to jaw morphology. Overall, we highlight how variation in molecular and cellular programs can promote the phenomenal diversity and functional morphology achieved during amniote jaw evolution or lead to the range of jaw defects and disease that affect the human condition

Evidence for the h_b(1P) meson in the decay Upsilon(3S) --> pi0 h_b(1P)

Using a sample of 122 million Upsilon(3S) events recorded with the BaBar detector at the PEP-II asymmetric-energy e+e- collider at SLAC, we search for the $h_b(1P)$ spin-singlet partner of the P-wave chi_{bJ}(1P) states in the sequential decay Upsilon(3S) --> pi0 h_b(1P), h_b(1P) --> gamma eta_b(1S). We observe an excess of events above background in the distribution of the recoil mass against the pi0 at mass 9902 +/- 4(stat.) +/- 2(syst.) MeV/c^2. The width of the observed signal is consistent with experimental resolution, and its significance is 3.1sigma, including systematic uncertainties. We obtain the value (4.3 +/- 1.1(stat.) +/- 0.9(syst.)) x 10^{-4} for the product branching fraction BF(Upsilon(3S)-->pi0 h_b) x BF(h_b-->gamma eta_b).Comment: 8 pages, 4 postscript figures, submitted to Phys. Rev. D (Rapid Communications

Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients

The systematic review demonstrates that the IM plays a major role in the breakdown and transformation of the dietary substrates examined. However, recent human data are limited with the exception of data from studies examining fibres and polyphenols. Results observed in relation with dietary substrates were not always consistent or coherent across studies and methodological limitations and differences in IM analyses made comparisons difficult. Moreover, non-digestible components likely to reach the colon are often not well defined or characterised in studies making comparisons between studies difficult if not impossible. Going forward, further rigorously controlled randomised human trials with well-defined dietary substrates and utilizing omic-based technologies to characterise and measure the IM and their functional activities will advance the field. Current evidence suggests that more detailed knowledge of the metabolic activities and interactions of the IM hold considerable promise in relation with host health

Examining the effectiveness of general practitioner and nurse promotion of electronic cigarettes versus standard care for smoking reduction and abstinence in hardcore smokers with smoking-related chronic disease:protocol for a randomised controlled trial

BACKGROUND: Despite the clear harm associated with smoking tobacco, many people with smoking-related chronic diseases or serious mental illnesses (SMI) are unwilling or unable to stop smoking. In many cases, these smokers have tried and exhausted all methods to stop smoking and yet clinicians are repeatedly mandated to offer them during routine consultations. Providing nicotine through electronic cigarettes (e-cigarettes) may reduce the adverse health consequences associated with tobacco smoking, but these are not currently offered. The aim of this study is to examine the feasibility, acceptability and effectiveness of general practitioners (GPs) and nurses delivering a brief advice intervention on e-cigarettes and offering an e-cigarette starter pack and patient support resources compared with standard care in smokers with smoking-related chronic diseases or SMI who are unwilling to stop smoking. METHODS/DESIGN: This is an individually randomised, blinded, two-arm trial. Smokers with a smoking-related chronic condition or SMI with no intention of stopping smoking will be recruited through primary care registers. Eligible participants will be randomised to one of two groups if they decline standard care for stopping smoking: a control group who will receive no additional support beyond standard care; or an intervention group who will receive GP or nurse-led brief advice about e-cigarettes, an e-cigarette starter pack with accompanying practical support booklet, and telephone support from experienced vapers and online video tutorials. The primary outcome measures will be smoking reduction, measured through changes in cigarettes per day and 7-day point-prevalence abstinence at 2 months. Secondary outcomes include smoking reduction, 7-day point-prevalence abstinence and prolonged abstinence at 8 months. Other outcomes include patient recruitment and follow-up, patient uptake and use of e-cigarettes, nicotine intake, contamination of randomisation and practitioner adherence to the delivery of the intervention. Qualitative interviews will be conducted in a subsample of practitioners, patients and the vape team to garner their reactions to the programme. DISCUSSION: This is the first randomised controlled trial to investigate whether e-cigarette provision alongside a brief intervention delivered by practitioners leads to reduced smoking and abstinence among smokers with smoking-related chronic diseases or SMI. TRIAL REGISTRATION: ISRCTN registry, ISRCTN59404712. Registered 28/11/17

Study of Bbar --> Xu l nubar decays in BBbar events tagged by a fully reconstructed B-meson decay and determination of |V_{ub}|

We report measurements of partial branching fractions for inclusive charmless semileptonic B decays Bbar --> Xu l nubar, and the determination of the CKM matrix element |V_{ub}|. The analysis is based on a sample of 467 million Upsilon(4S) --> BBar decays recorded with the BaBar detector at the PEP-II e^+ e^- storage rings. We select events in which the decay of one of the B mesons is fully reconstructed and an electron or a muon signals the semileptonic decay of the other B meson. We measure partial branching fractions DeltaB in several restricted regions of phase space and determine the CKM element |V_{ub}| based on four different QCD predictions. For decays with a charged lepton momentum p_l^* > 1.0 GeV in the B meson rest frame, we obtain DeltaB = (1.80 \pm 0.13 (stat.) \pm 0.15 (sys.) \pm 0.02 (theo.)) \times 10^{-3} from a fit to the two-dimensional mX-q^2 distribution. Here, mX refers to the invariant mass of the final state hadron X and q^2 is the invariant mass squared of the charged lepton and neutrino. From this measurement we extract |V_{ub}| = (4.33\pm 0.24 (exp.) \pm 0.15 (theo.)) \times 10^{-3} as the arithmetic average of four results obtained from four different QCD predictions of the partial rate. We separately determine partial branching fractions for B^0 and B^- decays and derive a limit on the isospin breaking in Bbar --> Xu l nubar decays.Comment: 26 pages, 9 postscript figures, 9 tables, accepted for publication in PR

Search for the Z1(4050)+Z_1(4050)^+ and Z2(4250)+Z_2(4250)^+ states in Bˉ0→χc1K−π+\bar B^0 \to \chi_{c1} K^- \pi^+ and B+→χc1KS0π+B^+ \to \chi_{c1} K^0_S \pi^+

We search for the $Z_1(4050)^+$ and $Z_2(4250)^+$ states, reported by the Belle Collaboration, decaying to $\chi_{c1} \pi^+$ in the decays $\bar B^0 \to \chi_{c1} K^- \pi^+$ and $B^+ \to \chi_{c1} K^0_S \pi^+$ where \chi_{c1} \to \jpsi \gamma. The data were collected with the BaBar detector at the SLAC PEP-II asymmetric-energy $e^+e^-$ collider operating at center-of-mass energy 10.58 GeV, and correspond to an integrated luminosity of 429 fb$^{-1}$. In this analysis, we model the background-subtracted, efficiency-corrected $\chi_{c1}\pi$ mass distribution using the $K \pi$ mass distribution and the corresponding normalized $K \pi$ Legendre polynomial moments, and then test the need for the inclusion of resonant structures in the description of the $\chi_{c1}\pi$ mass distribution. No evidence is found for the $Z_1(4050)^+$ and $Z_2(4250)^+$ resonances, and 90% confidence level upper limits on the branching fractions are reported for the corresponding $B$-meson decay modes.Comment: 15 pages, 12 postscript figures, to be published in Phys. Rev.