14 research outputs found
Spin-orbit qubit in a semiconductor nanowire
Motion of electrons can influence their spins through a fundamental effect
called spin-orbit interaction. This interaction provides a way to electrically
control spins and as such lies at the foundation of spintronics. Even at the
level of single electrons, spin-orbit interaction has proven promising for
coherent spin rotations. Here we report a spin-orbit quantum bit implemented in
an InAs nanowire, where spin-orbit interaction is so strong that spin and
motion can no longer be separated. In this regime we realize fast qubit
rotations and universal single qubit control using only electric fields. We
enhance coherence by dynamically decoupling the qubit from the environment. Our
qubits are individually addressable: they are hosted in single-electron quantum
dots, each of which has a different Land\'e g-factor. The demonstration of a
nanowire qubit opens ways to harness the advantages of nanowires for use in
quantum computing. Nanowires can serve as one-dimensional templates for
scalable qubit registers. Unique to nanowires is the possibility to easily vary
the material even during wire growth. Such flexibility can be used to design
wires with suppressed decoherence and push semiconductor qubit fidelities
towards error-correction levels. Furthermore, electrical dots can be integrated
with optical dots in p-n junction nanowires. The coherence times achieved here
are sufficient for the conversion of an electronic qubit into a photon, the
flying qubit, for long-distance quantum communication
Preparation and stability of poly(ethylene glycol) (PEG)ylated octreotide for application to microsphere delivery
The purpose of this study was to prepare poly(ethylene glycol) (PEG)ylated octreotide and investigate the stability against acylation by polyester polymers such as poly(lactic acid) and poly(lactic-co-glycolic acid). Octreotide was modified by reaction with monomethoxy PEG-propionaldehyde (molecular weight 5,000) in the presence of sodium cyanoborohydride. The mono-PEGylated fraction was isolated by reverse-phase high-performance liquid chromatography (HPLC) and characterized by matrixassisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Circular dichroism demonstrated no significant secondary structural differences between mono-PEGylated octreotide (mono-PEG-octreotide) and intact octreotide. As a test system for the stability study against acylation reaction, lactic acid (LA) solutions with various concentrations and pH values were prepared with water dilution and subsequent accelerated equilibration at 90°C for 24 hours. Native octreotide was found to be acylated in all the diluted LA solutions with different concentrations (42.5%, 21.3%, and 8.5%, wt/wt) and pH values (2.25, 1.47, and 1.85, respectively). The remaining amounts of intact octreotide continuously decreased to 50% through 30 days of incubation at 37°C. MALDI-TOF MS identified the octreotide to be acylated by LA units. However, acylation reaction of mono-PEG-octreotide in LA solutions was negligible, and the remaining amounts of intact one through 30 days of incubation in LA solutions were also comparable to the initial concentration. These data suggest that mono-PEG-octreotide may prevent the acylation reaction in degrading PLA microspheres and possibly serve as a new source for somatostatin microsphere formulation