16 research outputs found
BNT162b2 or CoronaVac Vaccinations Are Associated With a Lower Risk of Myocardial Infarction and Stroke After SARSāCoVā2 Infection Among Patients With Cardiovascular Disease
Background:
COVIDā19 vaccines have demonstrated effectiveness against SARSāCoVā2 infection, hospitalization, and mortality. The association between vaccination and risk of cardiovascular complications shortly after SARSāCoVā2 infection among patients with cardiovascular disease remains unknown.
Methods and Results:
A caseācontrol study was conducted with cases defined as patients who had myocardial infarction or stroke within 28ādays after SARSāCoVā2 infection between January 1, 2022 and August 15, 2022. Controls were defined as all other patients who attended any health services and were not cases. Individuals without history of cardiovascular disease were excluded. Each case was randomly matched with 10 controls according to sex, age, Charlson comorbidity index, and date of hospital admission. Adjusted odds ratio with 95% CI was estimated using conditional logistic regression. We identified 808 cases matched with 7771 controls among all patients with cardiovascular disease. Results showed that vaccination with BNT162b2 or CoronaVac was associated with a lower risk of myocardial infarction or stroke after SARSāCoVā2 infection with a doseāresponse relationship. For BNT162b2, risk decreased from 0.49 (95% CI, 0.29ā0.84) to 0.30 (95% CI, 0.20ā0.44) and 0.17 (95% CI, 0.08ā0.34) from 1 to 3 doses, respectively. Similar trends were observed for CoronaVac, with risk decreased from 0.69 (95% CI, 0.57ā0.85) to 0.42 (95% CI, 0.34ā0.52) and 0.32 (95% CI, 0.21ā0.49) from 1 to 3 doses, respectively.
Conclusions:
Vaccination with BNT162b2 or CoronaVac is associated with a lower risk of myocardial infarction or stroke after SARSāCoVā2 infection among patients with cardiovascular disease
PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load
Synthesis and photosensitizing properties of conjugated polymers that contain chlorotricarbonyl bis(phenylimino)acenaphthene rhenium(I) complexes
A series of poly(p-phenylenevinylene)s that contain chlorotricarbonyl bis(phenylimino)acenaphthene rhenium(I) complexes on the conjugated main chain was synthesized by the palladium catalyzed coupling reaction. The chloride ligand could be displaced by the iodide generated in situ during the polymerization reaction. The ligand displacement reaction was studied by synthesizing two model compounds, whose structures were confirmed by X-ray crystallography. The metal content in the polymers could be adjusted by varying the monomer feed ratio in the polymerization. The photosensitizing properties of these metal-containing polymers were studied, and it was found that the photocurrent response was dependent on the metal content in the polymers. Multilayered photovoltaic devices were fabricated, and their properties were studied by irradiation with simulated solar light. Typical power conversion efficiencies for these devices were measured to be 0.06%, with a fill factor of approximately 0.2. Ā© 2004 Elsevier B.V. All rights reserved.link_to_subscribed_fulltex