26 research outputs found
Fluctuations as probe of the QCD phase transition and freeze-out in heavy ion collisions at LHC and RHIC
We discuss the relevance of higher order moments of net baryon number
fluctuations for the analysis of freeze-out and critical conditions in heavy
ion collisions at LHC and RHIC. Using properties of O(4) scaling functions, we
discuss the generic structure of these higher moments at vanishing baryon
chemical potential and apply chiral model calculations to explore their
properties at non-zero baryon chemical potential. We show that the ratios of
the sixth to second and eighth to second order moments of the net baryon number
fluctuations change rapidly in the transition region of the QCD phase diagram.
Already at vanishing baryon chemical potential they deviate considerably from
the predictions of the hadron resonance gas model which reproduce the second to
fourth order moments of the net proton number fluctuations at RHIC. We point
out that the sixth order moments of baryon number and electric charge
fluctuations remain negative at the chiral transition temperature. Thus, they
offer the possibility to probe the proximity of the thermal freeze-out to the
crossover line.Comment: 24 pages, 12 EPS files, revised version, to appear in EPJ
Absence of Morphotropic Phase Boundary Effects in BiFeO3-PbTiO3 Thin Films Grown via a Chemical Multilayer Deposition Method
Here, we report the unusual behaviour shown by the (BiFeO3)1-x-(PbTiO3)x
(BF-xPT) films prepared using a multilayer deposition approach by chemical
solution deposition method. Thin film samples of various compositions were
prepared by depositing several bilayers of BF and PT precursors by varying the
BF or PT layer thicknesses. X-ray diffraction showed that final samples of all
compositions show mixing of the two compounds resulting in a single phase
mixture, also confirmed by transmission electron microscopy. In contrast to
bulk equilibrium compositions, our samples show a monoclinic (MA type)
structure suggesting disappearance of morphotropic phase boundary (MPB) about x
= 0.30 as observed in the bulk. This is accompanied by the lack of any
enhancement of remnant polarization at MPB as shown by the ferroelectric
measurements. Magnetic measurements show that the magnetization of the samples
increases with increasing BF content. Significant magnetization of the samples
indicates melting of spin spirals in the BF-xPT arising from random
distribution of iron atoms across the film. Absence of Fe2+ ions in the films
was corroborated by X-ray photoelectron spectroscopy measurements. The results
illustrate that used thin film processing methodology significantly changes the
structural evolution in contrast to predictions from the equilibrium phase
diagram as well as modify the functional characteristics of BP-xPT system
dramatically.Comment: 15 pages, 6 figure
Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
Graphical Abstract Highlights d Derivation of human neocortical and spinal cord neuroepithelial stem (NES) cells d Zika virus (ZIKV) infects NES cells and radial glia, impairing mitosis and survival d ZIKV induces mitochondrial sequestration of centrosomal phospho-TBK1 d Nucleoside analogs inhibit ZIKV replication, protecting NES cells from cell death In Brief Onorati et al. establish neuroepithelial stem (NES) cells as a model for studying human neurodevelopment and ZIKV-induced microcephaly. Together with analyses in human brain slices and microcephalic human fetal tissue, they find that ZIKV predominantly infects NES and radial glial cells, reveal a pivotal role for pTBK1, and find that nucleoside analogs inhibit ZIKV replication, protecting NES cells from cell death
Milk proteins
Milk contains many types of proteins which are classified in two general categories caseins and whey proteins. Due to their nutritional and functional properties milk proteins products are widely used in the food industry. This chapter summarizes the current knowledge on milk protein fraction and their biological properties. The production of the mains protein-enriched products is described. In addition an overview of the current and potential biomedical applications of milk proteins is given.info:eu-repo/semantics/publishedVersio
Experimental and Theoretical Challenges in the Search for the Quark Gluon Plasma: The STAR Collaboration's Critical Assessment of the Evidence from RHIC Collisions
We review the most important experimental results from the first three years
of nucleus-nucleus collision studies at RHIC, with emphasis on results from the
STAR experiment, and we assess their interpretation and comparison to theory.
The theory-experiment comparison suggests that central Au+Au collisions at RHIC
produce dense, rapidly thermalizing matter characterized by: (1) initial energy
densities above the critical values predicted by lattice QCD for establishment
of a Quark-Gluon Plasma (QGP); (2) nearly ideal fluid flow, marked by
constituent interactions of very short mean free path, established most
probably at a stage preceding hadron formation; and (3) opacity to jets. Many
of the observations are consistent with models incorporating QGP formation in
the early collision stages, and have not found ready explanation in a hadronic
framework. However, the measurements themselves do not yet establish
unequivocal evidence for a transition to this new form of matter. The
theoretical treatment of the collision evolution, despite impressive successes,
invokes a suite of distinct models, degrees of freedom and assumptions of as
yet unknown quantitative consequence. We pose a set of important open
questions, and suggest additional measurements, at least some of which should
be addressed in order to establish a compelling basis to conclude definitively
that thermalized, deconfined quark-gluon matter has been produced at RHIC.Comment: 101 pages, 37 figures; revised version to Nucl. Phys.
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16178. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate
Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES) cells to model early human neurodevelopment and ZIKV-related neuropathogenesis. By analyzing human NES cells, organotypic fetal brain slices, and a ZIKV-infected micrencephalic brain, we show that ZIKV infects both neocortical and spinal NES cells as well as their fetal homolog, radial glial cells (RGCs), causing disrupted mitoses, supernumerary centrosomes, structural disorganization, and cell death. ZIKV infection of NES cells and RGCs causes centrosomal depletion and mitochondrial sequestration of phospho-TBK1 during mitosis. We also found that nucleoside analogs inhibit ZIKV replication in NES cells, protecting them from ZIKV-induced pTBK1 relocalization and cell death. We established a model system of human neural stem cells to reveal cellular and molecular mechanisms underlying neurodevelopmental defects associated with ZIKV infection and its potential treatment