3,572 research outputs found
A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder
Background: Melanopsin, a non-visual photopigment, may play a role in aberrant responses to low winter light levels in Seasonal Affective Disorder (SAD). We hypothesize that functional sequence variation in the melanopsin gene could contribute to increasing the light needed for normal functioning during winter in SAD. Methods: Associations between alleles, genotypes, and haplotypes of melanopsin in SAD participants (n = 130) were performed relative to controls with no history of psychopathology (n = 90). Results: SAD participants had a higher frequency of the homozygous minor genotype (T/T) for the missense variant rs2675703 (P10L) than controls, compared to the combined frequencies of C/C and C/T. Individuals with the T/T genotype were 5.6 times more likely to be in the SAD group than the control group, and all 7 (5%) of individuals with the T/T genotype at P10L were in the SAD group. Limitations: The study examined only one molecular component of the non-visual light input pathway, and recruitment methods for the comparison groups differed. Conclusion: These findings support the hypothesis that melanopsin variants may predispose some individuals to SAD. Characterizing the genetic basis for deficits in the non-visual light input pathway has the potential to define mechanisms underlying the pathological response to light in SAD, which may improve treatment. © 2008 Elsevier B.V
Metastable Vacua in Superconformal SQCD-like Theories
We study dynamical supersymmetry breaking in vector-like superconformal N=1
gauge theories. We find appropriate deformations of the superpotential to
overcome the problem of the instability of the non supersymmetric vacuum. The
request for long lifetime translates into constraints on the physical couplings
which in this regime can be controlled through efficient RG analysis.Comment: 17 pages, 7 figures, JHEP3.cl
Non Supersymmetric Metastable Vacua in N=2 SYM Softly Broken to N=1
We find non-supersymmetric metastable vacua in four dimensional N=2 gauge
theories softly broken to N=1 by a superpotential term. First we study the
simplest case, namely the SU(2) gauge theory without flavors. We study the
spectrum and lifetime of the metastable vacuum and possible embeddings of the
model in UV complete theories. Then we consider larger gauge group theories
with flavors. We show that when we softly break them to N=1, the potential
induced on specific submanifolds of their moduli space is identical to the
potential in lower rank gauge theories. Then we show that the potential
increases when we move away from this submanifold, allowing us to construct
metastable vacua on them in the theories that can be reduced to the SU(2) case.Comment: 29 pages, 10 figure
Direct Mediation and Metastable Supersymmetry Breaking for SO(10)
We examine a metastable Macroscopic SO(N) SQCD model of
Intriligator, Seiberg and Shih (ISS). We introduce various baryon and meson
deformations, including multitrace operators and explore embedding an SO(10)
parent of the standard model into two weakly gauged flavour sectors. Direct
fundamental messengers and the symmetric pseudo-modulus messenger mediate SUSY
breaking to the MSSM. Gaugino and sfermion masses are computed and compared for
each deformation type. We also explore reducing the rank of the magnetic quark
matrix of the ISS model and find an additional fundamental messenger.Comment: 43 pages, Latex. Version to appear in JHEP
Tree Level Metastability and Gauge Mediation in Baryon Deformed SQCD
We investigate supersymmetric QCD with gauge group SU(2) and a baryon
deformation to the superpotential. The existence of an uplifted vacuum at the
origin with tree level metastability is demonstrated. When this model is
implemented in a direct gauge mediation scenario we therefore find gaugino
masses which are comparable to sfermion masses and parameterised by an
effective number of messengers 1/8. All deformations are well motivated by
appealing to the electric theory and an R-symmetry. This R-symmetry is
explicitly broken by the same term responsible for supersymmetry breaking.
Moreover, the model does not suffer from the Landau pole problem and we find
that it can be described in terms of just two scales: the weak scale and a high
scale like the Planck or GUT scale. The model can be tested by searching for
new particles at the TeV scale charged under the visible sector gauge group.Comment: 17 pages, 7 figures, updated reference
Adverse drug reactions and off-label and unlicensed medicines in children: a nested case control study of inpatients in a pediatric hospital
Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) among pediatric inpatients, we aimed to test the hypothesis that OLUL status is a risk factor for ADRs
A new framework to assess relative ecosystem vulnerability to climate change
Climate change poses a growing risk to global biodiversity. To prioritize conservation efforts, identification of the species and ecosystems most at risk from further changes in climatic conditions is critically needed. Although frameworks are available to assess species vulnerability to climate change, we still lack an easily implementable, ecosystem‐level perspective to inform landscape management. Here, we introduce a novel, spatially explicit vulnerability framework able to generate assessments at the ecosystem scale and apply it to Mozambican forest mangroves, which are under growing pressures from climate change. Results show that most of these ecosystems are currently highly vulnerable to sea level rise, while mangroves in the Zambezia and Nampula districts are highly vulnerable to both sea level rise and tropical storms. Altogether, we believe the introduced assessment framework has clear potential to inform conservation planning and management at various spatial scales, and help achieve adaptive management in the face of climatic uncertainties
Thermal Evolution of the Non Supersymmetric Metastable Vacua in N=2 SU(2) SYM Softly Broken to N=1
It has been shown that four dimensional N=2 gauge theories, softly broken to
N=1 by a superpotential term, can accommodate metastable non-supersymmetric
vacua in their moduli space. We study the SU(2) theory at high temperatures in
order to determine whether a cooling universe settles in the metastable vacuum
at zero temperature. We show that the corrections to the free energy because of
the BPS dyons are such that may destroy the existence of the metastable vacuum
at high temperatures. Nevertheless we demonstrate the universe can settle in
the metastable vacuum, provided that the following two conditions are hold:
first the superpotential term is not arbitrarily small in comparison to the
strong coupling scale of the gauge theory, and second the metastable vacuum
lies in the strongly coupled region of the moduli space.Comment: 32 pages, 30 figure
Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions
Adverse drug reactions (ADRs) are an important cause of harm in children. Current data are incomplete due to methodological differences between studies: only half of all studies provide drug data, incidence rates vary (0.6% to 16.8%) and very few studies provide data on causality, severity and risk factors of pediatric ADRs. We aimed to determine the incidence of ADRs in hospitalized children, to characterize these ADRs in terms of type, drug etiology, causality and severity and to identify risk factors
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