Revenue Management of Reusable Resources with Advanced Reservations

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137568/1/poms12672_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137568/2/poms12672.pd

Limiting shapes for deterministic centrally seeded growth models

We study the rotor router model and two deterministic sandpile models. For the rotor router model in $\mathbb{Z}^d$, Levine and Peres proved that the limiting shape of the growth cluster is a sphere. For the other two models, only bounds in dimension 2 are known. A unified approach for these models with a new parameter $h$ (the initial number of particles at each site), allows to prove a number of new limiting shape results in any dimension $d \geq 1$. For the rotor router model, the limiting shape is a sphere for all values of $h$. For one of the sandpile models, and $h=2d-2$ (the maximal value), the limiting shape is a cube. For both sandpile models, the limiting shape is a sphere in the limit $h \to -\infty$. Finally, we prove that the rotor router shape contains a diamond.Comment: 18 pages, 3 figures, some errors corrected and more explanation added, to appear in Journal of Statistical Physic

Personality Maturation through Sense of Mastery?: Longitudinal Evidence from two Education-to-Work Transition Studies

Objective Why personality changes in young adulthood remains a critical theoretical and empirical question. We studied personality change during the education-to-work transition, including mean-level personality change and its specific timing, the degree of individual variability in change, and the link between sense of mastery and personality change. Methods We used two intensive longitudinal studies. Study 1 included 5 waves of data across 2 years during the university-to-work transition (N = 309; mean-aged 25). Study 2 included 3 waves of data across 8 months during an internship-heavy teacher education program (N = 317; mean-aged 22). We measured personality traits and work-related mastery with questionnaires and personality states and general mastery with the experience sampling method. Results First, we found no evidence for mean-level personality maturation but decreases in trait Conscientiousness. Second, young adults differed significantly in personality trait and state change. Third, young adults with higher levels of work-related sense of mastery showed more positive changes in trait Conscientiousness. Decreases in general sense of mastery predicted later decreases in state Emotional Stability and vice versa. Change in general sense of mastery correlated with personality state change. Conclusions Sense of mastery seems to be part of a dynamic short-term process underlying personality change in young adulthood

Validation and implementation of a custom 21-gene panel next-generation sequencing assay for myeloid neoplasms

Rapid and reliable mutational analysis of myeloid neoplasms is increasingly important for diagnostic, prognostic and therapeutic reasons. In this article we describe the development and validation of a custom next-generation sequencing (NGS) assay that reliably tests across a broad range of myeloid neoplasms, including AML, MDS, and myeloproliferative neoplasms. The lllumina TruSeq Custom Amplicon panel was designed to detect variants in 21 genes. The validation protocol included sequencing of cell lines (n=3) and patient samples (n=36) on an Illumina MiSeq platform. A read depth ≥100x was observed for &gt;97% of targeted bases. After filtering for artifacts, a specificity of 100% was obtained. A detection limit of ≤5% was observed for variants present in cell lines. On average two reportable variants were present in samples from patients with a myeloid neoplasm. In conclusion, the custom NGS assay provides an adequate routine assay for genetic analysis of variants present in myeloid neoplasms. Practical considerations on choice of targeted genes, type of assay and method of data analysis are provided in this report.</p

Endemic transmission of visceral leishmaniasis in Bhutan

Visceral leishmaniasis was first reported in Bhutan in 2006. We conducted studies of the parasite, possible vectors and reservoirs, and leishmanin skin test and risk factor surveys in three villages. Nineteen cases were reported from seven districts. Parasite typing yielded two novel microsatellite sequences, both related to Indian L. donovani. In one case village, 40 (18.5%) of 216 participants had positive leishmanin skin test results, compared with 3 (4.2%) of 72 in the other case village and 0 of 108 in the control village. Positive results were strongly associated with the village and increasing age. None of the tested dogs were infected. Eighteen sand flies were collected, 13 Phlebotomus species and 5 Sergentomyia species; polymerase chain reaction for leishmanial DNA was negative. This assessment suggests that endemic visceral leishmaniasis transmission has occurred in diverse locations in Bhutan. Surveillance, case investigations, and further parasite, vector, and reservoir studies are needed. The potential protective impact of bed nets should be evaluated.This assessment was made thanks to the support that the Spanish Agency for International Cooperation for Development (AECID) provides to WHO for the control of visceral leishmaniasis. We are grateful to Rinzin Namgay from the Ministry of Health, Bhutan and the staff from Karuna House canine shelter in Trashigang, Bhutan, for their support during the field study