Gender differences in health-related quality of life following total laryngectomy

Background: The impact of a total laryngectomy on an individual's life has primarily been measured from a male viewpoint reflecting the demographics of a diagnosis of laryngeal cancer. A small number of studies have looked specifically at females, but very few are comparison studies. Consequently, there is little consistent research regarding any potential gender differences. Aims: To investigate whether there are gender differences in perceptions of health-related quality of life and functional abilities following total laryngectomy. Methods & Procedures: A total of 43 participants (22 males, 21 females), who had undergone a total laryngectomy procedure at least one year previously, took part in the study. They completed The European Organisation for Research and Treatment of Cancer Core Questionnaire Version 3.0 (EORTC QLQ-C30) in conjunction with the disease-specific Head & Neck Cancer Module (QLQ-H&N35). Outcomes & Results: There were no significant differences between males and females on demographic and disease-related variables, except for the following: significantly more females lived alone and changed their employment status following surgery. Males had a significantly higher global health status/quality of life than females (p < 0.05) and significantly higher levels of physical (p = 0.01), emotional (p < 0.01), cognitive (p < 0.05) and social functioning (p < 0.05). After adjusting for differences in living arrangements and change in employment status, differences in emotional and social functioning remained significant. There was a general trend for females to have higher symptom/impairment levels and to report more treatment-related problems, but the majority of these differences were not significant. Conclusions & Implications: Following total laryngectomy, females appear to be worsely affected in aspects of quality of life than males. Emotional and social functioning are particularly vulnerable. The findings imply that rehabilitation programmes after total laryngectomy need to evaluate quality of life and address these specific areas in order to improve patient-reported long-term outcomes

Galactic Cannibalism: the Origin of the Magellanic Stream

We are in a privileged location in the Universe which allows us to observe galactic interactions from close range -- the merger of our two nearest dwarf satellite galaxies, the LMC and SMC. It is important to understand the local merger process before we can have confidence in understanding mergers at high redshift. We present high resolution Nbody+SPH simulations of the disruption of the LMC and SMC and the formation of the Magellanic Stream, and discuss the implications for galaxy formation and evolution.Comment: 2 pages, 1 figure, to appear in "The Evolution of Galaxies II: Basic Building Blocks", (2002) ed. M. Sauvage et al. (Kluwer

Diagnostics of Coronal Magnetic Fields Through the Hanle Effect in UV and IR Lines

The plasma thermodynamics in the solar upper atmosphere, particularly in the corona, are dominated by the magnetic field, which controls the flow and dissipation of energy. The relative lack of knowledge of the coronal vector magnetic field is a major handicap for progress in coronal physics. This makes the development of measurement methods of coronal magnetic fields a high priority in solar physics. The Hanle effect in the UV and IR spectral lines is a largely unexplored diagnostic. We use magnetohydrodynamic (MHD) simulations to study the magnitude of the signal to be expected for typical coronal magnetic fields for selected spectral lines in the UV and IR wavelength ranges, namely the H I Ly-$\alpha$ and the He I 10830 {\AA} lines. We show that the selected lines are useful for reliable diagnosis of coronal magnetic fields. The results show that the combination of polarization measurements of spectral lines with different sensitivities to the Hanle effect may be most appropriate for deducing coronal magnetic properties from future observations.Comment: 15 pages, 5 figures, Frontiers in Astronomy and Space Sciences, 201

Observationally-Motivated Analysis of Simulated Galaxies

The spatial and temporal relationships between stellar age, kinematics, and chemistry are a fundamental tool for uncovering the physics driving galaxy formation and evolution. Observationally, these trends are derived using carefully selected samples isolated via the application of appropriate magnitude, colour, and gravity selection functions of individual stars; conversely, the analysis of chemodynamical simulations of galaxies has traditionally been restricted to the age, metallicity, and kinematics of `composite' stellar particles comprised of open cluster-mass simple stellar populations. As we enter the Gaia era, it is crucial that this approach changes, with simulations confronting data in a manner which better mimics the methodology employed by observers. Here, we use the \textsc{SynCMD} synthetic stellar populations tool to analyse the metallicity distribution function of a Milky Way-like simulated galaxy, employing an apparent magnitude plus gravity selection function similar to that employed by the RAdial Velocity Experiment (RAVE); we compare such an observationally-motivated approach with that traditionally adopted - i.e., spatial cuts alone - in order to illustrate the point that how one analyses a simulation can be, in some cases, just as important as the underlying sub-grid physics employed.Comment: Accepted for publication in PoS (Proceedings of Science): Nuclei in the Cosmos XIII (Debrecen, Jul 2014); 6 pages; 3 figure

The [?/Fe] ratios of very metal-poor stars within the integrated galactic initial mass function theory

The aim of this paper is to quantify the amplitude of the predicted plateau in [α/Fe] ratios associated with the most metal-poor stars of a galaxy. We assume that the initial mass function (IMF) in galaxies is steeper if the star formation rate (SFR) is low – as per the integrated galactic initial mass function (IGIMF) theory. A variant of the theory, in which the IGIMF depends upon the metallicity of the parent galaxy, is also considered. The IGIMF theory predicts low [α/Fe] plateaus in dwarf galaxies, characterized by small SFRs. The [α/Fe] plateau is up to 0.7 dex lower than the corresponding plateau of the Milky Way. For a universal IMF one should expect instead that the [α/Fe] plateau is the same for all the galaxies, irrespective of their masses or SFRs. Assuming a strong dependence of the IMF on the metallicity of the parent galaxy, dwarf galaxies can show values of the [α/Fe] plateau similar to those of the Milky Way, and almost independent of the SFR. The [Mg/Fe] ratios of the most metal-poor stars in dwarf galaxies satellites of the Milky Way can be reproduced either if we consider metallicity-dependent IMFs or if the early SFRs of these galaxies were larger than we presently think. Present and future observations of dwarf galaxies can help disentangle between these different IGIMF formulations

Laser microprobe study of cosmic dust (IDPs) and potential source materials

The study of cosmic dust or interplanetary dust particles (IDP) can provide vital information about primitive materials derived primarily from comets and asteroids along with a small unknown fraction from the nearby interstellar medium. The study of these particles can enhance our understanding of comets along with the decoding of the history of the early solar system. In addition the study of the cosmic dust for IDP particles can assist in the elucidation of the cosmic history of the organogenic elements which are vital to life processes. Studies to date on these particles have shown that they are complex, heterogeneous assemblages of both amorphous and crystalline components. In order to understand the nature of these particles, any analytical measurements must be able to distinguish between the possible sources of these particles. A study was undertaken using a laser microprobe interfaced to a quadrupole mass spectrometer for the analysis of the volatile components present in cosmic dust particles, terrestrial contaminants present in the upper atmosphere, and primitive carbonaceous chondrites. From the study of the volatiles released from the carbonaceous materials it is hoped that one could distinguish between components and sources in the IDP particles analyzed. The technique is briefly described and results for the CI, CM, and CV chondrites and cosmic dust particle W7027B8 are presented

Multi-filter spectrophotometry simulations

To complement both the multi-filter observations of quasar environments described in these proceedings, as well as the proposed UBC 2.7 m Liquid Mirror Telescope (LMT) redshift survey, we have initiated a program of simulated multi-filter spectrophotometry. The goal of this work, still very much in progress, is a better quantitative assessment of the multiband technique as a viable mechanism for obtaining useful redshift and morphological class information from large scale multi-filter surveys