Management of a Venous Ulcer with Virechana Karma and internal medications - A Case Report

Background - Venous Ulcer is a very common disease encountered in surgical practice. There are many modality of treatment in contemporary science, yet it takes very long time for healing of the ulcer. Objective - This is a single case study depicting the effect of Virechana Karma along with internal medications in a case of chronic venous ulcer. Materials and Methods - In this study a male patient of 52 years presenting with a non healing ulcer on the right lower leg was diagnosed as venous ulcer. He was treated with Virechana Karma and internal medications along with Kashaya Parisheka to the ulcer. Result - After discharge, follow up of patient was done. Complete healing of wound was noted in 45 days. The changes in wound healing were documented during the stay in the hospital and during follow up. Conclusion - After Virechana a significant reduction in many of symptoms was noted. This treatment protocol has shown encouraging results in terms of early healing of the ulcer with low cost of the treatment when com

Multiple Fistula-In-Ano treated by Kshara Sutra - A Case Report

Fistula-in-ano is a chronic and troublesome disease encountered in general practice. It consists of 1.6% of all surgical admissions and leads to physical, psychological and social problems. The management includes various treatment modalities with variable outcomes. Ksharasutra is a medicated thread used in ano-rectal disorders particularly for the management of fistula-in-ano in Ayurveda. In this study Ksharasutra was prepared by Apamarga Kshara (Ash of Achyranthus aspera Linn.), Snuhi Ksheera (Euphorbia neriifolia Linn.) and turmeric powder (Curcuma longa Linn.). A patient with multiple fistula-in-ano was treated by application of Ksharasutra. This case study demonstrates the utility of Ksharasutra in Multiple Fistula-in ano

Implementation of Environment-Friendly Strategies for Energy Conservation and Mitigation of Climate Change – A Holistic Approach in Mangalagangotri Campus

The harnessing of renewable energies and mitigation of climate change are like two faces of a coin. Decentralized implementation and individual-level practices of eco-friendly strategies contribute a lot on a global scale. In this context, Mangalore University on its headquarters Mangalagangotri campus, adopted and implemented many eco-friendly activities, technologies, and policies for sustainable development. Installation of solar power panels for electricity generation, of the current estimated value of 23,13,311 kWh/month; replacement of incandescent bulbs with LED bulbs with an energy saving of around 62% and procurement of most energy-efficient electronic & electrical appliances (47%) are some of the technologies that have been implemented for energy conservation. Implementation of e-Governance and e-Office program of Govt of Karnataka, and campus management system, social media, and email-based official communications have significantly reduced the usage of papers (>70% ); a complete ban on single-use plastics; recycling of organic wastes through vermicomposting, pot-composting, biogas production; encouraging electric vehicles are some of the adopted strategies. Altogether these strategies have significantly reduced the release of greenhouse gases in and around the campus in our efforts to join with global efforts to drop carbon footprint below 2 tons by 2050. The rainwater harvesting through the rooftop catchments and check-dams contributed to ≈ 50% water conservation. The campus comprises 32.4% of its total area with natural vegetation (463192 m2) and currently with 30.8% planted vegetation (439670 m2) of the total area (1428540 m2). The campus biodiversity was further enriched by periodical tree plantation drives with special reference to the planting of fruit-yielding saplings. As an Institutional Social Responsibility (ISR), the university has been making efforts to disseminate the knowledge of eco-friendly practices, by conducting public awareness programs and publishing popular articles in regional language. Despite the COVID-19 pandemic and government-imposed lockdown to curb the spread of the novel coronavirus, the University has continued eco-friendly activities and setting up of infrastructures, by strictly following safety guidelines. Overall, our continued holistic approaches of various eco-friendly strategies, in terms of the utility of advanced technologies, eGovernance, solar energy, and rainwater harvesting, organic wastes management, recycling of solid wastes, and many others, have been implemented since its inception have significantly helped in saving energy and reduction in the emission of greenhouse gases.Keyword: Climate change; Eco-friendly strategies; Carbon footprint; Greenhouse gase

Satellite Image Classification using Clustering Algorithms with Edge Detection Operators

Image classification consists of image processing algorithms for grouping cells of similar characteristics together. Satellite image classification is essential to extract the information and identify the different components such as water dense region, roads, vegetation etc. from the classified image. In this paper, an attempt is made to locate and identify the different regions of interest using classification algorithms such as K means and Fuzzy-C Means. Comparison is done for both the algorithms in terms of computational time and memory requirements. Also, the algorithms are applied for the input image by considering different values of K and its discussion is presented in the paper. The algorithms are then applied for the given image with edge detection operators to obtain the better visual clarity of the edges

SYNTHESIS, IN VITRO ANTIBACTERIAL, TOXICITY AND MOLECULAR DOCKING ANTICANCER ACTIVITY OF NOVEL N-[(2-CHLOROQUINOLIN-3-YL) METHYLIDENE]-2-ANILINE SCHIFF'S BASES

Objective: Synthesis of N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j) and to study their in vitro antibacterial activity and in silico study towards cancer and malarial proteins. Methods: Various N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j) were synthesized by using 2-chloro-3-formyl quinoline and different anilines in presence of acetic acid as catalyst. All the new compounds were characterized by 1H-NMR, [13]C-NMR and LCMS analysis. The compounds 3a-j was subjected to antibacterial activity. In silico molecular properties were predicted using various online cheminformatic tools, the binding interactions with Human DNA topoisomerase I and Plasmodium falciparum lactate dehydrogenase proteins was studied through molecular docking and Irinotecan and mefloquine were used as reference drugs. Results: Fairly good yield of N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j) were synthesized by convenient and economical procedure. The preliminary in silico pharmacokinetics study reveals that the compounds 3a-j shows excellent drug like property. The toxicity profile of compounds 3a-h was found safe. The compounds 3a-j was exhibited promising MIC values against the both S. aureus and E. coli. Similarly the docking results predict that the compound 3d shown highest interaction by forming two hydrogen bonds against the cancer protein with the interaction energy-20.696 kcal/mol. Compound 3c exhibits highest dock score of-45.703 kcal/mol with two hydrogen bonds against malarial protein. Conclusion: From the results of docking studies of N-[(2-chloroquinolin-3-yl) methylidene]-2-aniline schiff bases (3a-j), it has been concluded that the compounds were found to exhibit multifunctional lead property, hence these compounds are worth to be considered as potential lead molecules for further study

Cadmium silicate nanopowders for radiation dosimetry application: Luminescence and dielectric studies

AbstractPure cadmium silicate (CdSiO3) nanophosphor was prepared by a low temperature solution combustion technique. In this technique, meso-structured silica was used as silica source. The prepared compounds were well characterized by powder X-ray diffraction (PXRD), scanning electron microscopy, high resolution transmission electron microscopy, Fourier transform infrared and UV–vis spectroscopic techniques. The PXRD peaks of as-formed sample are broad and amorphous in nature. The compound calcined at 800°C shows pure monoclinic phase, which is the lowest temperature reported so far to obtain in this phase. The average crystallite size for phase pure compound was found to be ∼31nm. The optical energy band gap of ∼5.6eV was observed for the compound. Raman spectrum of the sample showed the all possible states of vibrational motions of the prepared samples. The UV irradiated samples with different dose and time with constant heating rate exhibit the thermoluminescence (TL) with a well resolved glow peak at ∼160°C. The variation of TL intensity with dosage time results that the material was found to be quite useful in radiation dosimetry. The frequency dependent dielectric constant of the prepared sample exhibits high value at low frequency and vice versa

Processing of Al–12Si–TNM composites by selective laser melting and evaluation of compressive and wear properties

Al-12Si (80 vol%)-Ti52.4Al42.2Nb4.4Mo0.9B0.06 (at.%) (TNM) composites were successfully produced by the selective laser melting (SLM). Detailed structural and microstructural analysis shows the formation of the Al6MoTi intermetallic phase due to the reaction of the TNM reinforcement with the Al-12Si matrix during SLM. Compression tests reveal that the composites exhibit significantly improved properties (∼140 and ∼160 MPa higher yield and ultimate compressive strengths, respectively) compared with the Al-12Si matrix. However, the samples break at ∼6% total strain under compression, thus showing a reduced plasticity of the composites. Sliding wear tests were carried out for both the Al-12Si matrix and the Al-12Si-TNM composites. The composites perform better under sliding wear conditions and the wear rate increases with increasing loads. At high loads, the wear takes place at three different rates and the wear rate decreases with increasing experiment duration

British Lung Foundation/United Kingdom primary immunodeficiency network consensus statement on the definition, diagnosis, and management of granulomatous-lymphocytic interstitial lung disease in common variable immunodeficiency disorders

A proportion of people living with common variable immunodeficiency disorders develop granulomatous-lymphocytic interstitial lung disease (GLILD). We aimed to develop a consensus statement on the definition, diagnosis, and management of GLILD. All UK specialist centers were contacted and relevant physicians were invited to take part in a 3-round online Delphi process. Responses were graded as Strongly Agree, Tend to Agree, Neither Agree nor Disagree, Tend to Disagree, and Strongly Disagree, scored +1, +0.5, 0, −0.5, and −1, respectively. Agreement was defined as greater than or equal to 80% consensus. Scores are reported as mean ± SD. There was 100% agreement (score, 0.92 ± 0.19) for the following definition: “GLILD is a distinct clinico-radio-pathological ILD occurring in patients with [common variable immunodeficiency disorders], associated with a lymphocytic infiltrate and/or granuloma in the lung, and in whom other conditions have been considered and where possible excluded.” There was consensus that the workup of suspected GLILD requires chest computed tomography (CT) (0.98 ± 0.01), lung function tests (eg, gas transfer, 0.94 ± 0.17), bronchoscopy to exclude infection (0.63 ± 0.50), and lung biopsy (0.58 ± 0.40). There was no consensus on whether expectant management following optimization of immunoglobulin therapy was acceptable: 67% agreed, 25% disagreed, score 0.38 ± 0.59; 90% agreed that when treatment was required, first-line treatment should be with corticosteroids alone (score, 0.55 ± 0.51)

Multi-response analysis in the material characterisation of electrospun poly (lactic acid)/halloysite nanotube composite fibres based on Taguchi design of experiments: fibre diameter, non-intercalation and nucleation effects

Poly (lactic acid) (PLA)/halloysite nanotube (HNT) composite fibres were prepared by using a simple and versatile electrospinning technique. The systematic approach via Taguchi design of experiments (DoE) was implemented to investigate factorial effects of applied voltage, feed rate of solution, collector distance and HNT concentration on the fibre diameter, HNT non-intercalation and nucleation effects. The HNT intercalation level, composite fibre morphology, their associated fibre diameter and thermal properties were evaluated by means of X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), imaging analysis and differential scanning calorimetry (DSC), respectively. HNT non-intercalation phenomenon appears to be manifested as reflected by the minimal shift of XRD peaks for all electrospun PLA/HNT composite fibres. The smaller-fibre-diameter characteristic was found to be sequentially associated with the feed rate of solution, collector distance and applied voltage. The glass transition temperature (T g) and melting temperature (T m) are not highly affected by varying the material and electrospinning parameters. However, as the indicator of the nucleation effect, the crystallisation temperature (T c) of PLA/HNT composite fibres is predominantly impacted by HNT concentration and applied voltage. It is evident that HNT’s nucleating agent role is confirmed when embedded with HNTs to accelerate the cold crystallisation of composite fibres. Taguchi DoE method has been found to be an effective approach to statistically optimise critical parameters used in electrospinning in order to effectively tailor the resulting physical features and thermal properties of PLA/HNT composite fibres