7,317 research outputs found
Test, Control and Monitor System (TCMS) operations plan
The purpose is to provide a clear understanding of the Test, Control and Monitor System (TCMS) operating environment and to describe the method of operations for TCMS. TCMS is a complex and sophisticated checkout system focused on support of the Space Station Freedom Program (SSFP) and related activities. An understanding of the TCMS operating environment is provided and operational responsibilities are defined. NASA and the Payload Ground Operations Contractor (PGOC) will use it as a guide to manage the operation of the TCMS computer systems and associated networks and workstations. All TCMS operational functions are examined. Other plans and detailed operating procedures relating to an individual operational function are referenced within this plan. This plan augments existing Technical Support Management Directives (TSMD's), Standard Practices, and other management documentation which will be followed where applicable
Observationally-Motivated Analysis of Simulated Galaxies
The spatial and temporal relationships between stellar age, kinematics, and
chemistry are a fundamental tool for uncovering the physics driving galaxy
formation and evolution. Observationally, these trends are derived using
carefully selected samples isolated via the application of appropriate
magnitude, colour, and gravity selection functions of individual stars;
conversely, the analysis of chemodynamical simulations of galaxies has
traditionally been restricted to the age, metallicity, and kinematics of
`composite' stellar particles comprised of open cluster-mass simple stellar
populations. As we enter the Gaia era, it is crucial that this approach
changes, with simulations confronting data in a manner which better mimics the
methodology employed by observers. Here, we use the \textsc{SynCMD} synthetic
stellar populations tool to analyse the metallicity distribution function of a
Milky Way-like simulated galaxy, employing an apparent magnitude plus gravity
selection function similar to that employed by the RAdial Velocity Experiment
(RAVE); we compare such an observationally-motivated approach with that
traditionally adopted - i.e., spatial cuts alone - in order to illustrate the
point that how one analyses a simulation can be, in some cases, just as
important as the underlying sub-grid physics employed.Comment: Accepted for publication in PoS (Proceedings of Science): Nuclei in
the Cosmos XIII (Debrecen, Jul 2014); 6 pages; 3 figure
Galactic Archaeology and Minimum Spanning Trees
Chemical tagging of stellar debris from disrupted open clusters and
associations underpins the science cases for next-generation multi-object
spectroscopic surveys. As part of the Galactic Archaeology project TraCD
(Tracking Cluster Debris), a preliminary attempt at reconstructing the birth
clouds of now phase-mixed thin disk debris is undertaken using a parametric
minimum spanning tree (MST) approach. Empirically-motivated chemical abundance
pattern uncertainties (for a 10-dimensional chemistry-space) are applied to
NBODY6-realised stellar associations dissolved into a background sea of field
stars, all evolving in a Milky Way potential. We demonstrate that significant
population reconstruction degeneracies appear when the abundance uncertainties
approach 0.1 dex and the parameterised MST approach is employed; more
sophisticated methodologies will be required to ameliorate these degeneracies.Comment: To appear in "Multi-Object Spectroscopy in the Next Decade: Big
Questions, Large Surveys and Wide Fields"; Held: Santa Cruz de La Palma,
Canary Islands, Spain, 2-6 Mar 2015; ed. I Skillen & S. Trager; ASP
Conference Series (Figures now optimised for B&W printing
On characteristic equations, trace identities and Casimir operators of simple Lie algebras
Two approaches are developed to exploit, for simple complex or compact real
Lie algebras g, the information that stems from the characteristic equations of
representation matrices and Casimir operators. These approaches are selected so
as to be viable not only for `small' Lie algebras and suitable for treatment by
computer algebra. A very large body of new results emerges in the forms, a) of
identities of a tensorial nature, involving structure constants etc. of g, b)
of trace identities for powers of matrices of the adjoint and defining
representations of g, c) of expressions of non-primitive Casimir operators of g
in terms of primitive ones. The methods are sufficiently tractable to allow not
only explicit proof by hand of the non-primitive nature of the quartic Casimir
of g2, f4, e6, but also e.g. of that of the tenth order Casimir of f4.Comment: 39 pages, 8 tables, late
A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty
We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing primary total hip arthroplasty under spinal anaesthesia with levobupivacaine. One hundred and eight patients were randomly allocated to receive either ultrasound-guided fascia iliaca block with 2 mg.kg−1 levobupivacaine (fascia iliaca group) or spinal morphine 100 μg plus a sham ultrasound-guided fascia iliaca block using saline (spinal morphine group). The pre-defined non-inferiority margin was a median difference between the groups of 10 mg in cumulative intravenous morphine use in the first 24 h postoperatively. Patients in the fascia iliaca group received 25 mg more intravenous morphine than patients in the spinal morphine group (95% CI 9.0–30.5 mg, p < 0.001). Ultrasound-guided fascia iliaca block was significantly worse than spinal morphine in the provision of analgesia in the first 24 h after total hip arthroplasty. No increase in side-effects was noted in the spinal morphine group but the study was not powered to investigate all secondary outcomes
Field analysis of groundwater for volatile organic contaminants using on-column aqueous injection capillary gas chromatography
Northeast Utilities Service Company, Southern California Edison Company, Empire State Electric Energy Research Corporation, American Power Service Company, Standard Oil Company and New England Power Service Company under the MIT Energy Laboratory Utilites Progra
Revisiting the Quantum Group Symmetry of Diatomic Molecules
We propose a q-deformed model of the anharmonic vibrations in diatomic
molecules. We analyse the applicability of the model to the phenomenological
Dunham's expansion by comparing with experimental data. Our methodology
involves a global consistency analysis of the parameters that determine the
q-deformed system, when compared with fitted vibrational parameters to 161
electronic states in diatomic molecules. We show how to include both the
positive and the negative anharmonicities in a simple and systematic fashion.Comment: 15 pages, 3 Table
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers
Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal tumor biopsies is a significant challenge and minimally invasive biomarkers are required. Considering this, we have developed and validated a preclinical 'death-switch' model for the discovery of secreted biomarkers of tumour apoptosis using in vitro proteomics and in vivo evaluation of the novel imaging probe [ 18 F]ML-10 for non-invasive detection of apoptosis using positron emission tomography (PET). The 'death-switch' is a constitutively active mutant caspase-3 that is robustly induced by doxycycline to drive synchronous apoptosis in human colorectal cancer cells in vitro or grown as tumor xenografts. Deathswitch induction caused caspase-dependent apoptosis between 3 and 24 hours in vitro and regression of 'death-switched' xenografts occurred within 24 h correlating with the percentage of apoptotic cells in tumor and levels of an established cell death biomarker (cleaved cytokeratin-18) in the blood. We sought to define secreted biomarkers of tumor apoptosis from cultured cells using Discovery Isobaric Tag proteomics, which may provide candidates to validate in blood. Early after caspase-3 activation, levels of normally secreted proteins were decreased (e.g. Gelsolin and Midkine) and proteins including CD44 and High Mobility Group protein B1 (HMGB1) that were released into cell culture media in vitro were also identified in the bloodstream of mice bearing death-switched tumors. We also exemplify the utility of the death-switch model for the validation of apoptotic imaging probes using [ 18 F]ML-10, a PET tracer currently in clinical trials. Results showed increased tracer uptake of [ 18 F]ML-10 in tumours undergoing apoptosis, compared with matched tumour controls imaged in the same animal. Overall, the death-switch model represents a robust and versatile tool for the discovery and validation of apoptosis biomarkers. © 2013 Macmillan Publishers Limited. All rights reserved
Interprofessional curriculum on environmental and social determinants of health in rural Kenya: Aga Khan University East Africa University of California San Francisco integrated primary health care program
The Aga Khan University East Africa (AKU)-University of California San Francisco (UCSF) Integrated Primary Health Care Program (IPHC) is a public–private partnership with community and government to strengthen the primary health care (PHC) system in Kenya. IPHC provides opportunities for health professions students to work and learn together in the rural and underserved district of Kaloleni
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