1,843 research outputs found

    An integrated study of earth resources in the state of California using remote sensing techniques

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    The University of California has been conducting an investigation which seeks to determine the usefulness of modern remote sensing techniques for studying various components of California's earth resources complex. Most of the work has concentrated on California's water resources, but with some attention being given to other earth resources as well and to the interplay between them and California's water resources

    Carbon nitride as a ligand: edge-site coordination of ReCl(CO)(3)-fragments to g-C3N4

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    IR spectroscopy and model structural studies show binding of ReCl(CO)3-fragments to carbon nitride (g-C3N4) occurs via Îș2 N,Nâ€Č bidentate coordination

    Determinants of neighborhood activity of adults age 70 and over:A mixed-methods study

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    Background:This mixed-methods study investigated personal, interpersonal, and environmental factors salient to decisions about being active in neighborhoods of different levels of deprivation.Methods:Twenty-five participants age 70 years and older (10 women) with diverse physical activity levels provided data on their weekly activity patterns (using accelerometry) and their perceived barriers to exercise (questionnaire). They also participated in semistructured individual interviews exploring the barriers and facilitators influencing neighborhood activity.Results:Functional limitations, lack of intrinsic motivation, and not having an activity companion were the highest impact barriers. Walkable access to amenities, positive physical activity perceptions, and existing habit of being active were the highest impact facilitators.Conclusions:The perceived quality and accessibility of the built and natural environments influence neighborhood activity in older adults. However, this relationship might be altered through the influence of personal and interpersonal determinants such as maintenance of good health and functional ability and supportive social networks.</jats:sec

    p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate

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    The pan neurotrophin receptor p75(NTR) signals programmed cell death both during nervous system development and after neural trauma and disease in the adult. However, the molecular pathways by which death is mediated remain poorly understood. Here, we show that this cell death is initiated by activation of G-protein-coupled inwardly rectifying potassium (GIRK/Kir3) channels and a consequent potassium efflux. Death signals stimulated by neurotrophin-mediated cleavage of p75(NTR) activate GIRK channels through the generation and binding of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2/PIP2] to GIRK channels. Both GIRK channel activity and p75(NTR)-mediated neuronal death are inhibited by sequestration of PtdIns(4,5)P2 and application of GIRK channel inhibitors, whereas pertussis toxin treatment has no effect. Thus, p75(NTR) activates GIRK channels without the need for G(i/o)-proteins. Our results demonstrate a novel mode of activation of GIRK channels, representing an early step in the p75(NTR)-mediated cell death pathway and suggesting a function for these channels during nervous system development

    Trait–demography relationships underlying small mammal population fluctuations

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    1.Large-scale fluctuations in abundance are a common feature of small mammal populations and have been the subject of extensive research. These demographic fluctuations are often associated with concurrent changes in the average body mass of individuals, sometimes referred to as the “Chitty effect”. Despite the long-standing recognition of this phenomenon, an empirical investigation of the underlying coupled dynamics of body mass and population growth has been lacking. 2.Using long-term life-history data combined with a trait-based demographic approach, we examined the relationship between body mass and demography in a small mammal population that exhibits non-cyclic, large-scale fluctuations in abundance. We used data from the male segment of a 25-year study of the monogamous prairie vole, Microtus ochrogaster, in Illinois, USA. Specifically, we investigated how trait–demography relationships and trait distributions changed between different phases of population fluctuations, and the consequences of these changes for both trait and population dynamics. 3.We observed phase-specific changes in male adult body mass distribution in this population of prairie voles. Our analyses revealed that these changes were driven by variation in ontogenetic growth, rather than selection acting on the trait. The resulting changes in body mass influenced most life-history processes, and these effects varied among phases of population fluctuation. However, these changes did not propagate to affect the population growth rate due to the small effect of body mass on vital rates, compared to the overall differences in vital rates between phases. The increase phase of the fluctuations was initiated by enhanced survival, particularly of juveniles, and fecundity whereas the decline phase was driven by an overall reduction in fecundity, survival and maturation rates. 4.Our study provides empirical support, as well as a potential mechanism, underlying the observed trait changes accompanying population fluctuations. Body size dynamics and population fluctuations resulted from different life-history processes. Therefore, we conclude that body size dynamics in our population do not drive the observed population dynamics. This more in-depth understanding of different components of small mammal population fluctuations will help us to better identify the mechanistic drivers of this interesting phenomenon

    Ab initio calculations of the hydrogen bond

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    Recent x-ray Compton scattering experiments in ice have provided useful information about the quantum nature of the interaction between H2_2O monomers. The hydrogen bond is characterized by a certain amount of charge transfer which could be determined in a Compton experiment. We use ab-initio simulations to investigate the hydrogen bond in H2_2O structures by calculating the Compton profile and related quantities in three different systems, namely the water dimer, a cluster containing 12 water molecules and the ice crystal. We show how to extract estimates of the charge transfer from the Compton profiles.Comment: 16 pages, 7 figures, to appear in Phys. Rev.

    GRIDKIT: Pluggable overlay networks for Grid computing

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    A `second generation' approach to the provision of Grid middleware is now emerging which is built on service-oriented architecture and web services standards and technologies. However, advanced Grid applications have significant demands that are not addressed by present-day web services platforms. As one prime example, current platforms do not support the rich diversity of communication `interaction types' that are demanded by advanced applications (e.g. publish-subscribe, media streaming, peer-to-peer interaction). In the paper we describe the Gridkit middleware which augments the basic service-oriented architecture to address this particular deficiency. We particularly focus on the communications infrastructure support required to support multiple interaction types in a unified, principled and extensible manner-which we present in terms of the novel concept of pluggable overlay networks

    Optimising background-limited observing during bright-moon phases and twilight

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    For the majority of optical observing programs, the sky brightness provides the fundamental limit to signal detection such that the scientific feasibility is largely dictated by the moon phase. Since most observatories do not have the resources to build expensive high-resolution or infrared instruments, they are increasingly at a loss as to how to exploit bright time. We show that, with due consideration of the field and moon position, it is possible to undertake `dark time' observing programs under `bright time' conditions. Our recommendations are particularly appropriate to all-sky survey programs. In certain instances, there are gains in observing efficiency with the use of a polariser, which can significantly reduce the moonlight (or twilight) sky-background flux relative to an extraterrestrial flux. These gains are possible in background-limited cases because the sky background can be highly polarised, due to scattering, around ninety degrees away from the moon (or sun). To take advantage of this, only minor modifications to existing instruments are needed.Comment: 5 pages, 4 figures, accepted by MNRA
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