Evolving IT management frameworks towards a sustainable future

Information Technology (IT) Management Frameworks are a fundamental tool used by IT professionals to efficiently manage IT resources and are globally applied to IT service delivery and management. Sustainability is a recent notion that describes the need for economic, environmental and social development with- out compromising the ability of future generations to meet their own needs; this applies to businesses as well as society in general. Unfortunately, IT Management Frameworks do not take sustainability into account. To the practitioner this paper demonstrates sustainability integration thereby allowing CIOs and IT managers to improve the sustainability of their organisation. To the researcher this paper argues that sustainability concerns need to be provided to IT Management through its integration into the mainstream of IT Management Frameworks. This is demonstrated through the high-level integration of sustainability in Six Sigma, C OBI T, ITIL and PRINCE2

On Extracting Mechanical Properties from Nanoindentation at Temperatures up to 1000∘^{\circ}C

Alloyed MCrAlY bond coats, where M is usually cobalt and/or nickel, are essential parts of modern turbine blades, imparting environmental resistance while mediating thermal expansivity differences. Nanoindentation allows the determination of their properties without the complexities of traditional mechanical tests, but was not previously possible near turbine operating temperatures. Here, we determine the hardness and modulus of CMSX-4 and an Amdry-386 bond coat by nanoindentation up to 1000$^{\circ}$C. Both materials exhibit a constant hardness until 400$^{\circ}$C followed by considerable softening, which in CMSX-4 is attributed to the multiple slip systems operating underneath a Berkovich indenter. The creep behaviour has been investigated via the nanoindentation hold segments. Above 700$^{\circ}$C, the observed creep exponents match the temperature-dependence of literature values in CMSX-4. In Amdry-386, nanoindentation produces creep exponents very close to literature data, implying high-temperature nanoindentation may be powerful in characterising these coatings and providing inputs for material, model and process optimisations

Covid-19\u27s Effect on Education

The purpose for this paper is to inform the reader of what the effect of the Covid-19 pandemic has on students and teachers along with finding solutions. The biggest concern during this time is if students are meeting the required materials while in school. Many students are falling behind and there needs to be a solution on how to solve this problem. Covid has caused many problems in everyone’s life but, especially in the lives of students. Teachers are struggling to find solutions due to limitations of Nontraditional Instruction and virtual classrooms. Parents and teachers can team up to help one another out and to achieve the goals of their student(s)

Purification of prostaglandin E2-9-oxoreductase from human decidua vera

AbstractProstaglandin E2-9-oxoreductase (PGE2-9-OR), the enzyme which converts prostaglandin E2 (PGE2) to prostaglandin F2α (PGF2α), has been detected in human decidua vera. A 105-fold purification was achieved when the centrifuged homogenate was fractionated sequentially by DEAE—Trisacryl, hydroxyapatite—agarose gel, ultrogel AcA 44 and Matrex gel blue A gel chromatographies. The following kinetic constants for PGE2-9-OR have been obtained. The equilibrium constant with respect to PGE2 is 83 μM, the Michaelis constant, Km, for PGE2 is 80 μM, for NADPH 1.6 μM. The maximal velocity for the forward reaction is V1 = .203 pmol/min. The enzyme was inhibited by progesterone, oestradiol-17β, cortisol and pharmaceutical drugs. An activating effect could be demonstrated with Ca2+ and oxytocin. The occurrence of PGE2-9-OR in the decidua vera suggests that this enzyme may be responsible for the transformation of PGE2 to PGF2α in these tissues. This may be an important mechanism for the initiation and maintenance of uterine contractions

Thermoplastic deformation of silicon surfaces induced by ultrashort pulsed lasers in submelting conditions

A hybrid 2D theoretical model is presented to describe thermoplastic deformation effects on silicon surfaces induced by single and multiple ultrashort pulsed laser irradiation in submelting conditions. An approximation of the Boltzmann transport equation is adopted to describe the laser irradiation process. The evolution of the induced deformation field is described initially by adopting the differential equations of dynamic thermoelasticity while the onset of plastic yielding is described by the von Mise's stress. Details of the resulting picometre sized crater, produced by irradiation with a single pulse, are then discussed as a function of the imposed conditions and thresholds for the onset of plasticity are computed. Irradiation with multiple pulses leads to ripple formation of nanometre size that originates from the interference of the incident and a surface scattered wave. It is suggested that ultrafast laser induced surface modification in semiconductors is feasible in submelting conditions, and it may act as a precursor of the incubation effects observed at multiple pulse irradiation of materials surfaces.Comment: To appear in the Journal of Applied Physic

RNA secondary structure design

We consider the inverse-folding problem for RNA secondary structures: for a given (pseudo-knot-free) secondary structure find a sequence that has that structure as its ground state. If such a sequence exists, the structure is called designable. We implemented a branch-and-bound algorithm that is able to do an exhaustive search within the sequence space, i.e., gives an exact answer whether such a sequence exists. The bound required by the branch-and-bound algorithm are calculated by a dynamic programming algorithm. We consider different alphabet sizes and an ensemble of random structures, which we want to design. We find that for two letters almost none of these structures are designable. The designability improves for the three-letter case, but still a significant fraction of structures is undesignable. This changes when we look at the natural four-letter case with two pairs of complementary bases: undesignable structures are the exception, although they still exist. Finally, we also study the relation between designability and the algorithmic complexity of the branch-and-bound algorithm. Within the ensemble of structures, a high average degree of undesignability is correlated to a long time to prove that a given structure is (un-)designable. In the four-letter case, where the designability is high everywhere, the algorithmic complexity is highest in the region of naturally occurring RNA.Comment: 11 pages, 10 figure

Brief Cognitive Screening Tools for Primary Care Practice

Early detection and diagnosis of Alzheimer’s disease and other cognitive impairment presents as a critical issue facing primary and specialty care providers in Washington State. In order to address the gaps and challenges faced by providers, the Dementia Action Collaborative offers the current paper to provide information and guidance around early detection and diagnosis of memory loss and dementia, including Alzheimer’s disease. At the conclusion of this paper, providers should be able to identify indications and opportunities for detection, appropriate tools, and care pathways for individuals and families affected by cognitive impairment and dementia

Etched graphene quantum dots on hexagonal boron nitride

We report on the fabrication and characterization of etched graphene quantum dots (QDs) on hexagonal boron nitride (hBN) and SiO2 with different island diameters. We perform a statistical analysis of Coulomb peak spacings over a wide energy range. For graphene QDs on hBN, the standard deviation of the normalized peak spacing distribution decreases with increasing QD diameter, whereas for QDs on SiO2 no diameter dependency is observed. In addition, QDs on hBN are more stable under the influence of perpendicular magnetic fields up to 9T. Both results indicate a substantially reduced substrate induced disorder potential in graphene QDs on hBN

Reduction of Two-Dimensional Dilute Ising Spin Glasses

The recently proposed reduction method is applied to the Edwards-Anderson model on bond-diluted square lattices. This allows, in combination with a graph-theoretical matching algorithm, to calculate numerically exact ground states of large systems. Low-temperature domain-wall excitations are studied to determine the stiffness exponent y_2. A value of y_2=-0.281(3) is found, consistent with previous results obtained on undiluted lattices. This comparison demonstrates the validity of the reduction method for bond-diluted spin systems and provides strong support for similar studies proclaiming accurate results for stiffness exponents in dimensions d=3,...,7.Comment: 7 pages, RevTex4, 6 ps-figures included, for related information, see http://www.physics.emory.edu/faculty/boettcher

Ground-State and Domain-Wall Energies in the Spin-Glass Region of the 2D ±J\pm J Random-Bond Ising Model

The statistics of the ground-state and domain-wall energies for the two-dimensional random-bond Ising model on square lattices with independent, identically distributed bonds of probability $p$ of $J_{ij}= -1$ and $(1-p)$ of $J_{ij}= +1$ are studied. We are able to consider large samples of up to $320^2$ spins by using sophisticated matching algorithms. We study $L \times L$ systems, but we also consider $L \times M$ samples, for different aspect ratios $R = L / M$. We find that the scaling behavior of the ground-state energy and its sample-to-sample fluctuations inside the spin-glass region ($p_c \le p \le 1 - p_c$) are characterized by simple scaling functions. In particular, the fluctuations exhibit a cusp-like singularity at $p_c$. Inside the spin-glass region the average domain-wall energy converges to a finite nonzero value as the sample size becomes infinite, holding $R$ fixed. Here, large finite-size effects are visible, which can be explained for all $p$ by a single exponent $\omega\approx 2/3$, provided higher-order corrections to scaling are included. Finally, we confirm the validity of aspect-ratio scaling for $R \to 0$: the distribution of the domain-wall energies converges to a Gaussian for $R \to 0$, although the domain walls of neighboring subsystems of size $L \times L$ are not independent.Comment: 11 pages with 15 figures, extensively revise