Synthesis and biological activity of pyrazino[3,2,1-j,k]carbazoles

1133-113

2-(2,3,4,9-Tetra­hydro-1H-carbazol-1-ylidene)propane­dinitrile

In the title mol­ecule, C15H11N3, the dihedral angle between the benzene ring and the fused pyrrole ring is 1.07 (5)°. The cyclo­hexene ring adopts an envelope conformation: the dicyano­methyl­ene group at position 1 has a coplanar orientation. An intra­molecular N—H⋯N hydrogen bond generates an S(7) ring motif. Inter­molecular N—H⋯N hydrogen bonds form an R 2 2(14) ring in the crystal. A C—H⋯π inter­action involving the benzene ring is also found in the structure

1-(1-Hy­droxy-8-methyl-9H-carbazol-2-yl)ethanone

The title compound, C15H13NO2, crystallizes with four independent mol­ecules (A, B, C and D) in the asymmetric unit. The carbazole units are almost planar [maximum deviations = 0.015 (3) for A, 0.024 (3) for B, 0.026 (3) for C and 0.046 (3) Å for D]. In all four mol­ecules, there is an O—H⋯O hydrogen bond involving the hy­droxy substituent and the carbonyl O atom of the adjacent acetyl group, which forms a six-membered ring. In the crystal, the four independent mol­ecules are linked via N—H⋯O and C—H⋯O inter­actions

Synthesis, antimalarial and antibacterial activity of l-chloro-2-formyland pyrazolo[3,4-a]carbazole derivatives

314-31

Synthesis and structural confirmation on selective N-alkylation of (Z)-5-((5-chloro-1H-indol-3-l)methylene)thiazolidine-2,4-dione analogues with their molecular docking studies

In the present investigation, a series of novel (Z)-5-((5-chloro-1H-indol-3-yl)methylene)thiazolidine-2,4-dione analogues have been designed and synthesized in good yields with the objective of selective N-alkylation at thiazolidine 2,4-dione ring in competence with indole ring under basic conditions in the presence of aprotic solvent dimethylformamide (DMF). The newly synthesized compounds have been characterized by spectral data (IR, 1H and 13C NMR, NOE, NOESY, 1H-1H-COSY and LC-MS). Further, molecular docking and ADME studies have revealed that the newly synthesized compounds have very good docking score against antidiabetic and anti-inflammation activities (PPARy and COX-2) as compared with standard rosiglitazone.

3-Methyl-3,4-dihydro-9H-carbazol-1(2H)-one

In the title mol­ecule, C13H13NO, the dihedral angle between the benzene ring and the fused pyrrole ring is 2.03 (5)°. The methyl group at the 3-position has an equatorial orientation. The cyclo­hexene ring adopts an envelope conformation. Three C atoms of the cyclo­hexene ring, with their attached H atoms, and all atoms of the methyl group are disordered over two positions, the site-occupancy factors being 0.883 (2) and 0.117 (2). In the crystal structure, mol­ecules are stabilized by inter­molecular N—H⋯O hydrogen bonds. A C—H⋯π inter­action, involving the benzene ring, is also found

Synthesis of 3,4-dihydro-2,2-dimethyl-2H-pyranoflavones

158-16

2,5-Dimethyl-7,8,9,10-tetra­hydro­cyclo­hepta­[b]indol-6(5H)-one

In the title mol­ecule, C15H17NO, the dihedral angle between the benzene and pyrrole rings is 1.45 (13)°. The cyclo­heptene ring adopts a slightly distorted boat conformation. In the crystal structure, inter­molecular C—H⋯O hydrogen bonds are found

A Novel Loom for Alacrity of Protected Lawsuit dealings using Cloud Computing Environment

This paper suggest a well-organized information system for facilitate the litigation procedures Information System courts. The purpose is to decrease the duration of processing cases in courts. The aspiration is to save the time and effort of judges and lawyer. In addition, we make use of the advantages of electronic systems and reducing traffic especially in developed countries. Advanced Encryption Standard is used to encrypt all the manipulated data for each case. All read document are encrypted to attain secure information system Litigation process. This is because the big data for all cases will be stored on cloud environment