2,816 research outputs found
Complementarity in classical dynamical systems
The concept of complementarity, originally defined for non-commuting
observables of quantum systems with states of non-vanishing dispersion, is
extended to classical dynamical systems with a partitioned phase space.
Interpreting partitions in terms of ensembles of epistemic states (symbols)
with corresponding classical observables, it is shown that such observables are
complementary to each other with respect to particular partitions unless those
partitions are generating. This explains why symbolic descriptions based on an
\emph{ad hoc} partition of an underlying phase space description should
generally be expected to be incompatible. Related approaches with different
background and different objectives are discussed.Comment: 18 pages, no figure
Survey strategy optimization for the Atacama Cosmology Telescope
In recent years there have been significant improvements in the sensitivity
and the angular resolution of the instruments dedicated to the observation of
the Cosmic Microwave Background (CMB). ACTPol is the first polarization
receiver for the Atacama Cosmology Telescope (ACT) and is observing the CMB sky
with arcmin resolution over about 2000 sq. deg. Its upgrade, Advanced ACTPol
(AdvACT), will observe the CMB in five frequency bands and over a larger area
of the sky. We describe the optimization and implementation of the ACTPol and
AdvACT surveys. The selection of the observed fields is driven mainly by the
science goals, that is, small angular scale CMB measurements, B-mode
measurements and cross-correlation studies. For the ACTPol survey we have
observed patches of the southern galactic sky with low galactic foreground
emissions which were also chosen to maximize the overlap with several galaxy
surveys to allow unique cross-correlation studies. A wider field in the
northern galactic cap ensured significant additional overlap with the BOSS
spectroscopic survey. The exact shapes and footprints of the fields were
optimized to achieve uniform coverage and to obtain cross-linked maps by
observing the fields with different scan directions. We have maximized the
efficiency of the survey by implementing a close to 24 hour observing strategy,
switching between daytime and nighttime observing plans and minimizing the
telescope idle time. We describe the challenges represented by the survey
optimization for the significantly wider area observed by AdvACT, which will
observe roughly half of the low-foreground sky. The survey strategies described
here may prove useful for planning future ground-based CMB surveys, such as the
Simons Observatory and CMB Stage IV surveys.Comment: 14 Pages, 9 Figures, 4 Table
Renormalization Group Approach to Field Theory at Finite Temperature
Scalar field theory at finite temperature is investigated via an improved
renormalization group prescription which provides an effective resummation over
all possible non-overlapping higher loop graphs. Explicit analyses for the
lambda phi^4 theory are performed in d=4 Euclidean space for both low and high
temperature limits. We generate a set of coupled equations for the mass
parameter and the coupling constant from the renormalization group flow
equation. Dimensional reduction and symmetry restoration are also explored with
our improved approach.Comment: 29 pages, can include figures in the body of the text using epsf.st
Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease
Leigh Disease is a progressive neurometabolic disorder for which a clinical effective treatment is currently still lacking. Here, we report on the therapeutic efficacy of KH176, a new chemical entity derivative of Trolox, in Ndufs4 (-/-) mice, a mammalian model for Leigh Disease. Using in vivo brain diffusion tensor imaging, we show a loss of brain microstructural coherence in Ndufs4 (-/-) mice in the cerebral cortex, external capsule and cerebral peduncle. These findings are in line with the white matter diffusivity changes described in mitochondrial disease patients. Long-term KH176 treatment retained brain microstructural coherence in the external capsule in Ndufs4 (-/-) mice and normalized the increased lipid peroxidation in this area and the cerebral cortex. Furthermore, KH176 treatment was able to significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells in Ndufs4 (-/-) mice. These in vivo findings show that further development of KH176 as a potential treatment for mitochondrial disorders is worthwhile to pursue. Clinical trial studies to explore the potency, safety and efficacy of KH176 are ongoing
Feedback-error learning control for powered assistive devices
Active orthoses (AOs) are becoming relevant for user-oriented training in gait rehabilitation. This implies efficient responses of AO's low-level controllers with short time modeling for medical applications. This thesis investigates, in an innovative way, the performance of Feedback-Error Learning (FEL) control to time-effectively adapt the AOs' responses to user-oriented trajectories and changes in the dynamics due to the interaction with the user. FEL control comprises a feedback PID controller and a neural network feedforward controller to promptly learn the inverse dynamics of two AOs. It was carried out experiments with able-bodied subjects walking on a treadmill and considering external disturbances to user-AO interaction. Results showed that the FEL control effectively tracked the user-oriented trajectory with position errors between 5% to 7%, and with a mean delay lower than 25 ms. Compared to a single PID control, the FEL control decreased by 16.5% and 90.7% the position error and delay, respectively. Moreover, the feedforward controller was able to learn the inverse dynamics of the two AOs and adapt to variations in the user-oriented trajectories, such as speed and angular range, while the feedback controller compensated for random disturbances. FEL demonstrated to be an efficient low-level controller for controlling AOs during gait rehabilitation.This work has been supported in part by the Fundação para a Ciência e Tecnologia (FCT) with the Reference Scholarship under Grant SFRH/BD/108309/2015, and part by the FEDER Funds through the Programa Operacional Regional do Norte and national funds from FCT with the project SmartOs - Controlo Inteligente de um Sistema Ortótico Ativo e Autónomo - under Grant NORTE-01-0145-FEDER-030386, and by the FEDER Funds through the COMPETE 2020—Programa Operacional Competitividade e Internacionalização (POCI)—with the Reference Project under Grant POCI-01-0145-FEDER-006941
Comparative phylogeography and asymmetric hybridization between cryptic bat species
This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordCryptic speciation and hybridization are two key processes that affect the origin and maintenance of biodiversity and our ability to understand and estimate it. To determine how these two processes interact, we studied allopatric and sympatric colonies of two cryptic bat species (Eptesicus serotinus and Eptesicus isabellinus) with parapatric distribution in the Iberian Peninsula. These species are the main reservoir for the most commonly rabies virus found in bats in Europe: the European bat Lyssavirus type 1 (EBLV‐1). We used mtDNA and nuclear microsatellite markers to confirm the taxonomic status of both species and to show a more pronounced and geographically based genetic structure in E. isabellinus than in its sibling E. serotinus. Using approximate Bayesian computation (ABC), we inferred rapid range expansion in both species after the Last Glacial Maximum until reaching their present distributions. ABC analysis also supported interspecific differences in genetic diversity and structure, pointing to an earlier expansion of E. isabellinus northward. We found no evidence of mitochondrial introgression between species, but nuclear markers identified a male‐mediated ongoing asymmetric hybridization from E. isabellinus to E. serotinus (28% hybrids in E. serotinus and 5% in E. isabellinus) in the contact zone. Although none of the bats studied tested positive for Lyssavirus RNA, the asymmetric hybridization supports the potential for the recently suggested interspecific transmission of EBLV‐1 from E. isabellinus into E. serotinus.Severo Ochoa ProgramMinisterio de Agricultura, Alimentación y Medio AmbienteConsejo Superior de Investigaciones CientíficasMinisterio de Ciencia e InnovaciónNatural Environment Research Council (NERC
The Atacama Cosmology Telescope: The polarization-sensitive ACTPol instrument
The Atacama Cosmology Telescope (ACT) is designed to make high angular
resolution measurements of anisotropies in the Cosmic Microwave Background
(CMB) at millimeter wavelengths. We describe ACTPol, an upgraded receiver for
ACT, which uses feedhorn-coupled, polarization-sensitive detector arrays, a 3
degree field of view, 100 mK cryogenics with continuous cooling, and meta
material anti-reflection coatings. ACTPol comprises three arrays with separate
cryogenic optics: two arrays at a central frequency of 148 GHz and one array
operating simultaneously at both 97 GHz and 148 GHz. The combined instrument
sensitivity, angular resolution, and sky coverage are optimized for measuring
angular power spectra, clusters via the thermal Sunyaev-Zel'dovich and kinetic
Sunyaev-Zel'dovich signals, and CMB lensing due to large scale structure. The
receiver was commissioned with its first 148 GHz array in 2013, observed with
both 148 GHz arrays in 2014, and has recently completed its first full season
of operations with the full suite of three arrays. This paper provides an
overview of the design and initial performance of the receiver and related
systems
Future therapeutic targets in rheumatoid arthritis?
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will develop joint deformity and progressive functional impairment. With the implementation of treat-to-target strategies and availability of biologic therapies, the outcomes for patients with RA have significantly improved. However, the unmet need in the treatment of RA remains high as some patients do not respond sufficiently to the currently available agents, remission is not always achieved and refractory disease is not uncommon. With better understanding of the pathophysiology of RA, new therapeutic approaches are emerging. Apart from more selective Janus kinase inhibition, there is a great interest in the granulocyte macrophage-colony stimulating factor pathway, Bruton's tyrosine kinase pathway, phosphoinositide-3-kinase pathway, neural stimulation and dendritic cell-based therapeutics. In this review, we will discuss the therapeutic potential of these novel approaches
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