Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature

<p>Abstract</p> <p>Background</p> <p>Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties.</p> <p>Methods</p> <p>We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm). We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials.</p> <p>Results and discussion</p> <p>Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.</p> <p>Conclusion</p> <p>The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.</p

β-cyclodextrin columns for separation of fluorous and non-fluorous compounds: How to use β-cyclodextrin columns in fluorous mixture synthesis and racemic synthesis

Guidelines for the use of β-cyclodextrin columns in fluorous and non-fluorous mixture synthesis, and racemic synthesis are suggested. Fluorous compounds can be separated more efficiently with SUMICHIRAL OA-7000 and -7100, while non-fluorous compounds can be separated better with SUMICHIRAL OA-7500. When the ratio of water in the mobile phase is large (>20%), the guard column (GL cart) can improve the separability of the fluorinated mixture

Divalent, trivalent, and heavy fermion states in Eu compounds

International audienc

食生活診断に関する研究(2報) : 栄養・食品摂取からみた食材料費の消費構造について

"T社の社宅に居住する主婦に対して,食材料費と栄養・食品摂取状況の関係について検討を行なった。食材料費の多少別に食品の摂取についてみた結果,食材料費を少なく要している群においては,漬物,豆製品類の他は多く要している群より少ない。一方,食材料費を多く要している群においては,嗜好性を追っている傾向にある。栄養摂取については,食材料費を少なく要している群はすべての栄養素が所要量を満たしていないことが問題点としてあげられる。食材料費を多く要している群は,平均値において少ない群よりもすべての栄養素について多く摂取していた。しかし分散が大きく,なかでも微量栄養素においては,所要量に対する不足者がかなり出現していることを認めた。これらのことから,食材料費を少なく要している群に対しては,積極的に食品摂取をするように促し,食材料費を多く要している群に対しては,栄養のバランスを配慮するような教育が望まれる。