Evaluating Mental Health Capitation Treatment: Lessons from Panel Data

The paper evaluates a capitation-financed system of mental health services delivery developed in Rochester, New York. Cost/benefit analysis of the treatment program is implemented on three years of data using program evaluation techniques. Patient outcomes are compared across randomly assigned study groups as well as across enrollment status. The analysis implements difference-in-difference econometric techniques recently developed in the labor economics literature to control for potentially non-random attrition as well as selective non-compliance. We find that patients enrolled in the capitation program do experience significantly lower costs without becoming sicker, even after controlling for attrition and sample selection.

Determinan Komplikasi Persalinan Pada Ibu Pernah Menikah Usia 15-49 Tahun Di Provinsi Banten Tahun 2007

Latar belakang:Angka kematian ibu belum menunjukkan penurunan signifikan di Provinsi Banten.Provinsi ini menjadi salah satu dari enam provinsi dengan kematian ibu tertinggi di Indonesia.Berdasarkan data profil kesehatan di Provinsi Banten tahun 2010, menunjukkan bahwa kematian ibu tertinggi berada pada masa persalinan akibat komplikasi. Tujuan: Mengetahui determinan komplikasi persalinan pada ibu di Provinsi Banten tahun 2007. Metode:Penelitian ini menganalisis data survei demografi dan kesehatan Indonesia (SDKI) tahun 2007 dengan desain penelitian cross sectional. Sampel dalam penelitian adalah ibu usia 15-49 tahun yang pernah melahirkan anak dalam kurun lima tahun terakhir sebelum survei di Provinsi Banten, sebesar 561 ibu. RR diperoleh melaluianalisiscox regression. Hasil:Ibu pernah menikahusia 15-49 tahun yang mengalami komplikasi persalinan di Provinsi Banten sebesar 43 persen. Penolong persalinan merupakan faktor protektif, ibu yang persalinannya ditolong oleh tenaga kesehatan dapat mengurangi risiko untuk terjadinya komplikasi persalinan (RR 0,63; 95%CI 0.5030.792). Kesimpulan:Kejadian komplikasi persalinan masih tinggi di Provinsi Banten. Persalinan lama menjadi jenis komplikasi persalinan terbanyak.Salah satu determinan komplikasi persalinan adalah penolong persalinan

Temperature Chaos in Two-Dimensional Ising Spin Glasses with Binary Couplings: a Further Case for Universality

We study temperature chaos in a two-dimensional Ising spin glass with random quenched bimodal couplings, by an exact computation of the partition functions on large systems. We study two temperature correlators from the total free energy and from the domain wall free energy: in the second case we detect a chaotic behavior. We determine and discuss the chaos exponent and the fractal dimension of the domain walls.Comment: 5 pages, 6 postscript figures; added reference

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

Nitrogen-containing-bisphosphonates (N-BPs) are widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts, the mechanism by which N-BPs enter the cytosol from the extracellular space to reach their molecular target is not understood. Here we implemented a CRISPRi-mediated genome-wide screen and identified SLC37A3 (solute carrier family 37 member A3) as a gene required for the action of N-BPs in mammalian cells. We observed that SLC37A3 forms a complex with ATRAID (all-trans retinoic acid-induced differentiation factor), a previously identified genetic target of N-BPs. SLC37A3 and ATRAID localize to lysosomes and are required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol. Our results elucidate the route by which N-BPs are delivered to their molecular target, addressing a key aspect of the mechanism of action of N-BPs that may have significant clinical relevance

A PHABULOSA/cytokinin feedback loop controls root growth in arabidopsis

The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [ [1], [2], [3], [4], [5] and [6]]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations

Probabilistic performance modelling when using partial reconfiguration to accelerate streaming applications with non-deterministic task scheduling

Many streaming applications composed of multiple tasks self-adapt their tasks’ execution at runtime as response to the processed data. This type of application promises a better solution to context switches at the cost of a non-deterministic task scheduling. Partial reconfiguration is a unique feature of FPGAs that not only offers a higher resource reuse but also performance improvements when properly applied. In this paper, a probabilistic approach is used to estimate the acceleration of streaming applications with unknown task schedule thanks to the application of partial reconfiguration. This novel approach provides insights in the feasible acceleration when partially reconfiguring regions of the FPGA are partially reconfigured in order to exploit the available resources by processing multiple tasks in parallel. Moreover, the impact of how different strategies or heuristics affect to the final performance is included in this analysis. As a result, not only an estimation of the achievable acceleration is obtained, but also a guide at the design stage when searching for the highest performance

The doubling of the superorbital period of Cyg X-1

We study properties of the superorbital modulation of the X-ray emission of Cyg X-1. We find that it has had a stable period of about 300 d in soft and hard X-rays and in radio since 2005 until at least 2010, which is about double the previously seen period. This new period, seen in the hard spectral state only, is detected not only in the light curves but also in soft X-ray hardness ratios and in the amplitude of the orbital modulation. On the other hand, the spectral slope in hard X-rays, >20 keV, averaged over superorbital bins is constant, and the soft and hard X-rays and the radio emission change in phase. This shows that the superorbital variability consists of changing the normalization of an intrinsic spectrum of a constant shape and of changes of the absorbing column density with the phase. The maximum column density is achieved at the superorbital minimum. The amplitude changes are likely to be caused by a changing viewing angle of an anisotropic emitter, most likely a precessing accretion disc. The constant shape of the intrinsic spectrum shows that this modulation is not caused by a changing accretion rate. The modulated absorbing column density shows the presence of a bulge around the disc centre, as proposed previously. We also find the change of the superorbital period from about 150 d to about 300 d to be associated with almost unchanged average X-ray fluxes, making the period change difficult to explain in the framework of disc-irradiation models. Finally, we find no correlation of the X-ray and radio properties with the reported detections in the GeV and TeV gamma-ray range.Comment: MNRAS, in press, 8 page

The core population and kinematics of a massive clump at early stages: an ALMA view

High-mass star formation theories make distinct predictions on the properties of the prestellar seeds of high-mass stars. Observations of the early stages of high-mass star formation can provide crucial constraints, but they are challenging and scarce. We investigate the properties of the prestellar core population embedded in the high-mass clump AGAL014.492-00.139, and we study the kinematics at the clump and the clump-to-core scales. We have analysed an extensive dataset acquired with the ALMA interferometer. Applying a dendrogram analysis to the Band o-$\rm H_2D^+$ data, we identified 22 cores. We have fitted their average spectra in local-thermodinamic-equilibrium conditions, and we analysed their continuum emission at $0.8 \, \rm mm$. The cores have transonic to mildly supersonic turbulence levels and appear mostly low-mass, with $M_\mathrm{core}< 30 \, \rm M_\odot$. Furthermore, we have analysed Band 3 observations of the $\rm N_2H^+$ (1-0) transition, which traces the large scale gas kinematics. Using a friend-of-friend algorithm, we identify four main velocity coherent structures, all of which are associated with prestellar and protostellar cores. One of them presents a filament-like structure, and our observations could be consistent with mass accretion towards one of the protostars. In this case, we estimate a mass accretion rate of $\dot{M}_\mathrm{acc}\approx 2 \times 10^{-4} \rm \, M_\odot \, yr^{-1}$. Our results support a clump-fed accretion scenario in the targeted source. The cores in prestellar stage are essentially low-mass, and they appear subvirial and gravitationally bound, unless further support is available for instance due to magnetic fields.Comment: Accepted for publication in Ap

Sestrin2 is a leucine sensor for the mTORC1 pathway

Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller. Amino acids signal to mTORC1 through the Rag guanosine triphosphatases (GTPases). Several factors regulate the Rags, including GATOR1, aGTPase-activating protein; GATOR2, a positive regulator of unknown function; and Sestrin2, a GATOR2-interacting protein that inhibits mTORC1 signaling. We find that leucine, but not arginine, disrupts the Sestrin2-GATOR2 interaction by binding to Sestrin2 with a dissociation constant of 20 micromolar, which is the leucine concentration that half-maximally activates mTORC1. The leucine-binding capacity of Sestrin2 is required for leucine to activate mTORC1 in cells. These results indicate that Sestrin2 is a leucine sensor for the mTORC1 pathway.United States. National Institutes of Health (R01CA103866)United States. National Institutes of Health (AI47389)United States. Department of Defense (W81XWH-07-0448)United States. National Institutes of Health (T32 GM007753)United States. National Institutes of Health (F30 CA189333)United States. National Institutes of Health (F31 CA180271