Anatomy Teaching, a “Model” Answer? Evaluating “Geoff”, a Painted Anatomical Horse, as a Tool for Enhancing Topographical Anatomy Learning

Development of new methods for anatomy teaching is increasingly important as we look to modernize and supplement traditional teaching methods. In this study, a life‐sized equine model, “Geoff” was painted with surface and deep anatomical structures with the aim of improving students’ ability to convert theoretical knowledge into improved topographical anatomy knowledge on the live horse. Third and fourth year veterinary medicine students (n = 45) were randomly allocated into experimental (used “Geoff”) and control (used textbook) groups. The efficacy of the model was evaluated through a structured oral exam using a live horse. Questionnaires gathered information on student confidence and enjoyment of the task. There was no significant difference in the performance of experimental and control groups either immediately (44±20% vs. 40±21%; P = 0.504) or 9 weeks after the learning intervention (55±17% vs. 55±20%; P = 0.980). There were however specific questions on which the experimental group performed better than controls, and for which gender effects were apparent. The students using “Geoff” showed a transient gain in confidence following the session (Likert scale 2.7 to 3.6) however the initial increase was no longer present at the second test. There was a significant influence of gender on confidence with greater confidence gains in females in the Experimental group. The students found the model to be extremely useful and both groups found the sessions enjoyable. The model will be of benefit as a complementary learning tool for students

Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats

Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30% of the patients, have important adverse effects and its use is limited by their high cost. Therefore, compounds that can control arthritis, with an acceptable safety profile and low production costs are still an unmet need. We have shown, in vitro, that celastrol inhibits both IL-1β and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties. Our main goal in this work was to test the effect of celastrol in the number of sublining CD68 macrophages (a biomarker of therapeutic response for novel RA treatments) and on the overall synovial tissue cellularity and joint structure in the adjuvant-induced rat model of arthritis (AIA).FCT fellowship: (SFRH/BPD/92860/2013)

Fretting wear behavior on LPBF processed AlSi10Mg alloy for different heat treatment conditions

To widen the industrial application of additively manufactured (AM) parts, the study of fretting wear behavior is essential, as it ensures the safety and reliability that drive innovation in design and materials. This study explores the fretting wear behavior of the as-built and heat-treated state of AlSi10Mg alloy fabricated, viz., laser powder bed fusion (LPBF). Initially, the as-built and T5, T6, and stress-relieved (SR) heat-treated samples were examined using scanning electron microscopy (SEM) to gain insights into the microstructural changes. The as-built samples exhibited a higher hardness level (135 HV) primarily due to the presence of very fine microstructure of the α-Al cellular matrix with embedded Si. The α-Al cellular structure dissolved with various heat treatments, and Si particles coarsened. The hardness decreased to 85, 79, and 67 HV for the T5, T6, and SR conditions, respectively. Subsequently, fretting tests were conducted on the samples, applying various normal loads of 10, 50, and 100 N. Further, the samples were characterized by the coefficient of friction (COF), worn surface morphology, and wear volume loss. The investigation showed that the as-built material showed less wear volume loss under all loading conditions than the heat-treated conditions. Furthermore, the T5 heat treated sample had a lower wear volume when compared to the T6 and SR heat-treated samples. The heat-treated sample exhibits compressive stress, whereas the LPBF processed, the as-built sample shows tensile stress