211 research outputs found

    What is the impact of acquired immunity on the transmission of schistosomiasis and the efficacy of current and planned mass drug administration programmes?

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    Schistosomiasis causes severe morbidity in many countries with endemic infection with the schistosome digenean parasites in Africa and Asia. To control and eliminate the disease resulting from infection, regular mass drug administration (MDA) is used, with a focus on school-aged children (SAC; 5-14 years of age). In some high transmission settings, the World Health Organization (WHO) also recommends the inclusion of at-risk adults in MDA treatment programmes. The question of whether ecology (age-dependant exposure) or immunity (resistance to reinfection), or some combination of both, determines the form of observed convex age-intensity profile is still unresolved, but there is a growing body of evidence that the human hosts acquire some partial level of immunity after a long period of repeated exposure to infection. In the majority of past research modelling schistosome transmission and the impact of MDA programmes, the effect of acquired immunity has not been taken into account. Past work has been based on the assumption that age-related contact rates generate convex horizontal age-intensity profiles. In this paper, we use an individual based stochastic model of transmission and MDA impact to explore the effect of acquired immunity in defined MDA programmes. Compared with scenarios with no immunity, we find that acquired immunity makes the MDA programme less effective with a slower decrease in the prevalence of infection. Therefore, the time to achieve morbidity control and elimination as a public health problem is longer than predicted by models with just age-related exposure and no build-up of immunity. The level of impact depends on the baseline prevalence prior to treatment (the magnitude of the basic reproductive number R0) and the treatment frequency, among other factors. We find that immunity has a larger impact within moderate to high transmission settings such that it is very unlikely to achieve morbidity and transmission control employing current MDA programmes

    Transforming aquatic agricultural systems towards gender equality: a five country review

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    Aquatic agricultural systems (AAS) are systems in which the annual production dynamics of freshwater and/or coastal ecosystems contribute significantly to total household income. Improving the livelihood security and wellbeing of the estimated 250 million poor people dependent on AAS in Bangladesh, Cambodia, the Philippines, the Solomon Islands and Zambia is the goal of the Worldfish Center-led Consortium Research Program (CRP), “Harnessing the development potential of aquatic agricultural systems for development.” One component expected to contribute to sustainably achieving this goal is enhancing the gender and wider social equity of the social, economic and political systems within which the AAS function. The CRP’s focus on social equity, and particularly gender equity, responds to the limited progress to date in enhancing the inclusiveness of development outcomes through interventions that offer improved availability of resources and technologies without addressing the wider social constraints that marginalized populations face in making use of them. The CRP aims to both offer improved availability and address the wider social constraints in order to determine whether a multi-level approach that engages with individuals, households and communities, as well as the wider social, economic and political contexts in which they function, is more successful in extending development’s benefits to women and other excluded groups. Designing the research in development initiatives to test this hypothesis requires a solid understanding of each CRP country’s social, cultural and economic contexts and of the variations across them. This paper provides an initial input into developing this knowledge, based on a review of literature on agriculture, aquaculture and gender relations within the five focal countries. Before delving into the findings of the literature review, the paper first justifies the expectation that successfully achieving lasting wellbeing improvements for poor women and men dependent on AAS rests in part on advances in gender equity, and in light of this justification, presents the AAS CRP’s conceptual frame

    Application of Geophysical Techniques for 3D Geohazard Mapping to Delineate Cavities and Potential Sinkholes in the Northern Part of Kuala Lumpur, Malaysia

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    This work describes the application of the electrical resistivity (ER) method to delineating subsurface structures and cavities in Kuala Lumpur Limestone within the Batu Cave area of Selangor Darul Ehsan, Malaysia. In all, 17 ER profiles were measured by using a Wenner electrode configuration with 2 m spacing. The field survey was accompanied by laboratory work, which involves taking resistivity measurements of rock, soil, and water samples taken from the field to obtain the formation factor. The relationship between resistivity and the formation factor and porosity for all the samples was established. The porosity values were plotted and contoured. A 2-dimensional and 3-dimensional representation of the subsurface topography of the area was prepared through use of commercial computer software. The results show the presence of cavities and sinkholes in some parts of the study area. This work could help engineers and environmental managers by providing the information necessary to produce a sustainable management plan in order to prevent catastrophic collapses of structures and other related geohazard problems

    Poverty In Nigeria and Government Efforts Towards Its Alleviation

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    Nigeria, the most populous country not only in Sub-Saharan Africa but the continent as a whole, is highly endowed with natural resources, and being the 6th largest crude oil exporter in the world, its people are paradoxically wallowing in excruciating poverty. Historically, the trend of poverty in Nigeria is that of the upsurge. In 1980, for instance, the number of people living in poverty increased from 27% to 46% in 1985 and from 55% in 2004 to 61% in 2010 and 64% in 2013 (World Bank, 2013). Consequently, the need arises for concerted effort to be made to tackle the menace of poverty in the country. Thus, several poverty alleviation programmes were undertaken by the Federal Government of Nigeria (FGN) as an indication of its commitment to alleviate poverty in the country. Reviewing relevant literature, we evaluate poverty alleviation programmes in this paper. We conclude that despite enormous resources allocated to poverty elevation programmes, poverty levels did not decline but has increased over time. This failure is explained by corruption, overlapping functions and rivalry among executing agencies, as well as political interference. Recommendations for improving poverty alleviation programmes and making them more effective are provided in this paper

    βdecay of the 21/2^+ isomer in ^<93>Mo and level structure of ^<93>Nb

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    The γ rays associated with β decay of the 21/2^+ isomer in ^Mo (Ex=2.425 MeV, T_=6.85 h) were measured with a selective sensitivity to long-lived isomer decays. A new 1262-keV transition was found in the γ-γ coincidence measurement, and it was attributed to a transition in ^Nb, which is the daughter nucleus of the β decay of the ^Mo isomer, from the 2.753- to the 1.491-MeV levels. Accurate γ-ray intensity balances have determined the β-decay intensity from the ^Mo isomer to the 2.753-MeV level in ^Nb and placed no appreciable intensity for the previously reported β-decay branching to the 2.180-MeV level, for which a recent in-beam γ-ray experiment assigned to be I^π = 17/2^-. Based on the γ-ray intensities from the 2.753-MeV level, spin-parity assignment of this level was revised from 21/2^+ to 19/2^+. The observed β-decay intensity and the spin-parity assignment were explained by the jj-coupling shell model calculations

    Relación entre el valor del ratio elastográfico y la clasificación citológica de Bethesda en la patología tiroidea

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    ResumenObjetivoPresentar nuestra experiencia en la categorización de la patología tiroidea, a través de la utilización de parámetros ecográficos de malignidad y elastografía con medición del ratio de la deformación tisular, y la correlación de los hallazgos obtenidos con la clasificación citológica de Bethesda.Materiales y métodosSe llevó a cabo un estudio prospectivo y observacional, entre septiembre de 2012 y abril de 2013, que incluyó 137 nódulos tiroideos. Se excluyeron 10 casos Bethesda III-IV. Se realizó ecografía, power Doppler, visualización de micropartículas (Micropure) y elastografía con medición del ratio elastográfico, así como también punción aspirativa con aguja fina guiada por ecografía (con el citólogo presente), utilizando la clasificación Bethesda. Los estudios fueron hechos por el mismo operador con un ecógrafo Toshiba Aplio 400 y los datos estadísticos se evaluaron con el programa IBM SPSS Statistics 20.ResultadosSe estudiaron 127 nódulos en pacientes con una edad promedio de 59±16 años. El 82% de los casos ocurrió en mujeres. Ciento veinte nódulos (94%) fueron clasificados como Bethesda II. La media elastográfica para Bethesda I-II fue de 1,94±2,12 vs. 7,07±5,46 para V-VI (p: 0,048). El punto de corte elastográfico ≤ 2 (87 de 127) presentó una sensibilidad del 85,7% y una especificidad del 81,7% para predecir Bethesda asociada a patología benigna, con un valor predictivo negativo (VPN) del 99% y un valor predictivo positivo del 15%.ConclusionesEl ratio elastográfico permitió descartar la patología tiroidea maligna con valores ≤ 2 y un VPN del 99%, mejorando la selección de los pacientes a punzar. El incremento del ratio elastográfico se asoció a una mayor probabilidad de patología maligna, aunque no se pudo establecer un valor de corte debido al bajo número de casos con Bethesda V-VI.AbstractObjectivesWe present our experience in the categorization of thyroid pathology using the sonographic parameters of malignancy and elastography with measurement elastography strain ratio, to evaluate the relationship between the results found and the Bethesda classification.Materials and methodsProspective observational study, included 137 thyroid nodules studied between September 2012- April 2013. We excluded 10 cases with Bethesda categories III-IV. Ultrasonography, Doppler, Micropure, elastogrphy strain ratio between the lesion and the normal tissue, fine needle aspiration cytology (FNAC),were the diagnosis methods used. The pathologist was always present and the cytological classi fication of Bethesda was used. All study was made by the same physician used Toshiba Aplio 400 ultrasound unit. Results were analyzed with IBM SPSS Statistics 20.ResultsWe studied 127 nodules in patients 59±16 years old, 82% were female; 120 were Bethesda II (94%). The average strain ratio for nodules Bethesda I-II was 1.94±2.12 vs. 7.07±5.46 for those nodules Bethesda V-VI (p:0,048). This means that an elastography strain ratio ≤ 2 (87 of 127 nodules) has a sensibility of 85.7% and a specificity of 81.7% of predicting Bethesda associated with benign pathology with a negative predictive value (NPV) of 99% and a positive predictive value of 15%.ConclusionThe elastography strain ratio allowed to discard malignant nodules with strain ratio ≤ 2 with a NPV of 99% improves the selection of patients for FNAC. The increment in the elastography strain ratio was associated to a higher possibility of malignant thyroid pathology, being unable to determine a limit value due to the low amount of cases with nodules Bethesda V-VI
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