28 research outputs found
A review of sufentanil and the sufentanil sublingual tablet system for acute moderate to severe pain
OMC: An Optical Monitoring Camera for INTEGRAL - Instrument description and performance
The Optical Monitoring Camera (OMC) will observe the optical emission from the prime targets of the gammaray instruments onboard the ESA mission INTEGRAL, with the support of the JEM-X monitor in the X-ray domain. This capability will provide invaluable diagnostic information on the nature and the physics of the sources over a broad wavelength range. Its main scientific objectives are: ( 1) to monitor the optical emission from the sources observed by the gamma- and X-ray instruments, measuring the time and intensity structure of the optical emission for comparison with variability at high energies, and ( 2) to provide the brightness and position of the optical counterpart of any gamma- or X-ray transient taking place within its field of view. The OMC is based on a refractive optics with an aperture of 50 mm focused onto a large format CCD (1024 x 2048 pixels) working in frame transfer mode (1024 x 1024 pixels imaging area). With a field of view of 5degrees x 5degrees it will be able to monitor sources down to magnitude V = 18. Typical observations will perform a sequence of different integration times, allowing for photometric uncertainties below 0.1 mag for objects with V less than or equal to 16
Micro-ribonucleic acids and extracellular vesicles repertoire in the spent culture media is altered in women undergoing In Vitro Fertilization
Abstract MicroRNAs (miRNAs) are class of small RNA molecules with major impact on gene regulation. We analyzed the potential of miRNAs secreted from pre-implantation embryos into the embryonic culture media as biomarkers to predict successful pregnancy. Using microarray analysis, we profiled the miRNome of the 56 spent culture media (SCM) after embryos transfer and found a total of 621 miRNAs in the SCM. On average, we detected 163 miRNAs in SCM of samples with failed pregnancies, but only 149 SCM miRNAs of embryos leading to pregnancies. MiR-634 predicted an embryo transfer leading to a positive pregnancy with an accuracy of 71% and a sensitivity of 85%. Among the 621 miRNAs, 102 (16.4%) showed a differential expression between positive and negative outcome of pregnancy with miR-29c-3p as the most significantly differentially expressed miRNA. The number of extracellular vehicles was lower in SCM with positive outcomes (3.8 × 109/mL EVs), as compared to a negative outcome (7.35 × 109/mL EVs) possibly explaining the reduced number of miRNAs in the SCM associated with failed pregnancies. The analysis of the miRNome in the SCM of couples undergoing fertility treatment lays the ground towards development of biomarkers to predict successful pregnancy and towards understanding the role of embryonic miRNAs found in the SCM