2,150 research outputs found
Quark resonances and high E_t jets
Possible spin-3/2 quark resonances would have a significant effect on high
E_{\mbox{\rm t}} jet production through their contribution to the subprocess
. Such enhancements are compared to a, recently
reported, anomaly in inclusive jet production at the CDF detector.Comment: 7 pages set in RevTex with four postscript figures appended- all
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Hippocampal subfields and limbic white matter jointly predict learning rate in older adults
First published online: 04 December 2019Age-related memory impairments have been linked to differences in structural brain parameters, including cerebral white matter (WM) microstructure and hippocampal (HC) volume, but their combined influences are rarely investigated. In a population-based sample of 337 older participants aged 61-82 years (Mage = 69.66, SDage = 3.92 years), we modeled the independent and joint effects of limbic WM microstructure and HC subfield volumes on verbal learning. Participants completed a verbal learning task of recall over five repeated trials and underwent magnetic resonance imaging (MRI), including structural and diffusion scans. We segmented three HC subregions on high-resolution MRI data and sampled mean fractional anisotropy (FA) from bilateral limbic WM tracts identified via deterministic fiber tractography. Using structural equation modeling, we evaluated the associations between learning rate and latent factors representing FA sampled from limbic WM tracts, and HC subfield volumes, and their latent interaction. Results showed limbic WM and the interaction of HC and WM-but not HC volume alone-predicted verbal learning rates. Model decomposition revealed HC volume is only positively associated with learning rate in individuals with higher WM anisotropy. We conclude that the structural characteristics of limbic WM regions and HC volume jointly contribute to verbal learning in older adults
On-command enhancement of single molecule fluorescence using a gold nanoparticle as an optical nano-antenna
We investigate the coupling of a single molecule to a single spherical gold
nanoparticle acting as a nano-antenna. Using scanning probe technology, we
position the particle in front of the molecule with nanometer accuracy and
measure a strong enhancement of more than 20 times in the fluorescence
intensity simultaneous to a 20-fold shortening of the excited state lifetime.
Direct comparison with three-dimensional calculations allow us to decipher the
contributions of the excitation enhancement, spontaneous emission modification,
and quenching. Furthermore, we provide direct evidence for the role of the
particle plasmon resonance in the modification of the molecular emission.Comment: 5 pages, 4 figures. submitted to Phys.Rev.Lett. 12/04/200
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Quasi-static and dynamic deformation behaviour of Zr-based bulk metallic glass
Nano- and micro-indentation studies were carried out to characterise a plasticity mechanism through the evolution of localised shear bands that drive material's deformation at sub-micron length scale. Initial deformation of Zr-based bulk metallic glass (BMG) was investigated with nanoindentation tests using a spherical indenter. The indentation cycle reflects an elastic deformation with the yielding load of approx. 3 mN. For designed cycling indentation, hardening and softening phenomena were observed in nano- and micro-indentations, respectively. High-precision dynamic mechanical relaxation measurements were performed using a Dynamic Mechanical Analyzer (DMA), on decreasing frequency from 160 Hz to 0.1 Hz. A mechanical response of the BMG surface to a concentrated impact load was also studied. The obtained results indicated that the studied Zr-based BMG behaved as an elastic-perfectly plastic material at macroscale with discrete plasticity events at smaller length scales
An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins
Cytoplasmic poly(A)-binding proteins (PABPs) regulate mRNA stability and translation. Although predominantly localized in the cytoplasm, PABP proteins also cycle through the nucleus. Recent work has established that their steady-state localization can be altered by cellular stresses such as ultraviolet (UV) radiation, and infection by several viruses, resulting in nuclear accumulation of PABPs. Here, we present further evidence that their interaction with and release from mRNA and translation complexes are important in determining their sub-cellular distribution and propose an integrated model for regulated nucleo-cytoplasmic transport of PABPs
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