3,191 research outputs found
Massively Parallel Signal Processing using the Graphics Processing Unit for Real-Time BrainâComputer Interface Feature Extraction
The clock speeds of modern computer processors have nearly plateaued in the past 5 years. Consequently, neural prosthetic systems that rely on processing large quantities of data in a short period of time face a bottleneck, in that it may not be possible to process all of the data recorded from an electrode array with high channel counts and bandwidth, such as electrocorticographic grids or other implantable systems. Therefore, in this study a method of using the processing capabilities of a graphics card [graphics processing unit (GPU)] was developed for real-time neural signal processing of a brainâcomputer interface (BCI). The NVIDIA CUDA system was used to offload processing to the GPU, which is capable of running many operations in parallel, potentially greatly increasing the speed of existing algorithms. The BCI system records many channels of data, which are processed and translated into a control signal, such as the movement of a computer cursor. This signal processing chain involves computing a matrixâmatrix multiplication (i.e., a spatial filter), followed by calculating the power spectral density on every channel using an auto-regressive method, and finally classifying appropriate features for control. In this study, the first two computationally intensive steps were implemented on the GPU, and the speed was compared to both the current implementation and a central processing unit-based implementation that uses multi-threading. Significant performance gains were obtained with GPU processing: the current implementation processed 1000 channels of 250âms in 933âms, while the new GPU method took only 27âms, an improvement of nearly 35 times
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Prospective Associations between Religiousness/Spirituality and Depression and Mediating Effects of Forgiveness in a Nationally Representative Sample of United States Adults
The present investigation examines the prospective associations of religiousness/spirituality with depression and the extent to which various dimensions of forgiveness act as mediating mechanisms of these associations. Data are from a nationally representative sample of United States adults who were first interviewed in 1998 and reinterviewed six months later. Measures of religiousness/spirituality, forgiveness, and various sociodemographics were collected. Depression was assessed using the Composite International Diagnostic Interview administered by trained interviewers. Results showed that religiousness/spirituality, forgiveness of oneself and others, and feeling forgiven by God were associated, both cross-sectionally and longitudinally, with depressive status. After controlling for initial depressive status, only forgiveness of oneself and others remained statistically significant predictors of depression. Path analyses revealed that religiousness/spirituality conveyed protective effects, prospectively, on depression by way of an indirect path through forgiveness of others but not forgiveness of oneself. Hence, forgiveness of others acts as a mechanism of the salutary effect of religiousness/spirituality, but forgiveness of oneself is an independent predictor. Conclusions regarding the continued development of this type of research and for the treatment of clients with depression are offered
Positive Reappraisals After an Offense: Event-related Potentials and Emotional Effects of Benefit-finding and Compassion
Using a within subjects design, three emotion regulation strategies (compassionâfocused reappraisal, benefitâfocused reappraisal, and offense rumination) were tested for their effects on forgiveness, wellâbeing, and eventârelated potentials (ERPs). Participants (N = 37) recalled a recent interpersonal offense as the context for each emotion regulation strategy. Both decisional and emotional forgiveness increased significantly for the two reappraisal strategies compared to offense rumination. Compassionâfocused reappraisal prompted the greatest increase in both decisional and emotional forgiveness. Furthermore, both reappraisal strategies increased positively oriented wellâbeing measures (e.g., joy, gratitude) compared to offense rumination, with compassionâfocused reappraisal demonstrating the largest effect on empathy. Late positive potential (LPP) amplitudes in response to unpleasant affect words were larger following the benefitâfocused reappraisal strategy, indicating frontal LPP augmentation due to affective incongruence of the unpleasant stimuli with the positive, silverâlining orientation of the benefitâfocused reappraisal emotion regulation strategy
Discovery of a dark, massive, ALMA-only galaxy at z~5-6 in a tiny 3-millimeter survey
We report the serendipitous detection of two 3 mm continuum sources found in
deep ALMA Band 3 observations to study intermediate redshift galaxies in the
COSMOS field. One is near a foreground galaxy at 1.3", but is a previously
unknown dust-obscured star-forming galaxy (DSFG) at probable ,
illustrating the risk of misidentifying shorter wavelength counterparts. The
optical-to-mm spectral energy distribution (SED) favors a grey
attenuation curve and results in significantly larger stellar mass and SFR
compared to a Calzetti starburst law, suggesting caution when relating
progenitors and descendants based on these quantities. The other source is
missing from all previous optical/near-infrared/sub-mm/radio catalogs
("ALMA-only"), and remains undetected even in stacked ultradeep optical
( AB) and near-infrared ( AB) images. Using the ALMA position as
a prior reveals faint measurements in stacked IRAC 3.6+4.5,
ultradeep SCUBA2 850m, and VLA 3GHz, indicating the source is real. The
SED is robustly reproduced by a massive M and
M, highly obscured , star forming
Myr galaxy at redshift 1.1. The
ultrasmall 8 arcmin survey area implies a large yet uncertain
contribution to the cosmic star formation rate density CSFRD(z=5)
M yr Mpc, comparable to all
ultraviolet-selected galaxies combined. These results indicate the existence of
a prominent population of DSFGs at , below the typical detection limit of
bright galaxies found in single-dish sub-mm surveys, but with larger space
densities Mpc, higher duty cycles ,
contributing more to the CSFRD, and potentially dominating the high-mass galaxy
stellar mass function.Comment: Accepted for publication in ApJ. 2 galaxies, too many pages, 8
figures, 2 table
Chronic brain stimulation using Micro-ECoG devices
Recording and stimulating brain activity has had great success both as a research tool and as a clinical technique. Neural prosthetics can replace limbs, restore hearing, and treat disorders like Parkinsonâs and epilepsy, but are relatively crude. Current neural prosthetic systems use penetrating electrodes to achieve high precision, but the invasive nature of these devices provoke a strong immune response that limits chronic use. (Polikov et al) In our study we evaluate micro-electrocortiographic (micro-ECoG) devices which sit under the skull and on the surface of the brain for stimulation over chronic timescales. We anticipate these devices with their less invasive placement will evoke less extreme immune responses compared to penetrating electrodes and allow for stable stimulation over long periods of time (months to years). These devices were developed by the NITRO Lab of University of Wisconsin. (Thongpang et al) In short, Sprague Dawley rats were implanted with micro-ECoG devices over either somatosensory or auditor cortex. They were stimulated electrically through these devices on a daily basis to evaluate their chronic performance in vivo. Sensitivity to stimulation was determined via an operant behavioral task and the implantsâ electrical properties were measured daily to monitor functionality and approximate of the immune response. After at least two months of implantation, animals were perfused and a histological analysis was performed to evaluate the chronic immune response. From preliminary results we expect to see that the micro-ECoG devices are capable of long term stimulation and evoke a smaller immune response from the brain than penetrating neural implants. In addition, we have found that removing the dura in rats for device implantation causes significant brain swelling, which indicates a strong immune response preventing effective stimulation. This research shows that micro-ECoG devices can chronically stimulate brain tissue and show great promise as a less invasive method of neural interfacing compared to traditional penetrating electrodes
Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants
A series of animal experiments was conducted to characterize changes in the complex impedance of chronically implanted electrodes in neural tissue. Consistent trends in impedance changes were observed across all animals, characterized as a general increase in the measured impedance magnitude at 1 kHz. Impedance changes reach a peak approximately 7 days post-implant. Reactive responses around individual electrodes were described using immuno- and histo-chemistry and confocal microscopy. These observations were compared to measured impedance changes. Several features of impedance changes were able to differentiate between confined and extensive histological reactions. In general, impedance magnitude at 1 kHz was significantly increased in extensive reactions, starting about 4 days post-implant. Electrodes with extensive reactions also displayed impedance spectra with a characteristic change at high frequencies. This change was manifested in the formation of a semi-circular arc in the Nyquist space, suggestive of increased cellular density in close proximity to the electrode site. These results suggest that changes in impedance spectra are directly influenced by cellular distributions around implanted electrodes over time and that impedance measurements may provide an online assessment of cellular reactions to implanted devices.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58178/2/jne7_4_007.pd
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