Relato de caso de hidradenocarcinoma nodular

Relato de caso de hidradenocarcinoma nodular, neoplasia rara e pouco descrita na literatura, em paciente masculino, 78 anos, branco, procedente de área rural, atendido no SUS em julho de 2013, em Belém, Pará, Brasil. Foi observada lesão eritematonodular, com três meses de evolução, infiltrada, exulcerada, pouco dolorosa e sangrante, com 1 cm de diâmetro, na asa direita nasal, além de telangiectasias ao redor. A impressão diagnóstica foi carcinoma basocelular. A histopatologia identificou hidradenoma nodular maligno, confirmada pela imuno-histoquímica. A relevância deste relato é devida a raridade da doença e a falta de protocolo para tratamento específico da mesma.Case report of nodular hidradenocarcinoma, a rare neoplasm very little described in the literature, in male patient, 78 years old, caucasian, from a rural area, attended by SUS in july of 2013, Belém, Pará, Brazil. It was observed erythematododular lesion, with three months of evolution, infiltrated, exulcerated, slightly painful and bleeding, with 1 cm of diameter, in the right nasal wing, as well as telangiectasias around. The diagnostic impression was basal cell carcinoma. The histopathology identified malignant nodular hidradenoma, that was confirmed by immune-histochemistry. The relevance of this report is due to the rarity of the disease and the absence of protocol for specific treatment

Atopic Eczema Simulating Mammary Paget’s Disease in an Adult: Case Report

An atopic breast eczema is usually bilateral, with intense pruritus and good response to corticosteroids. The differential diagnosis with mammary Paget’s disease is fundamental, mainly in unilateral clinical manifestations, since it is frequently associated to adjacent breast tumors. The aim of the present report was to present a clinical condition of an atopic breast eczema through an exuberant and unilateral clinical presentation, emphasizing the need of the differential diagnosis for malignant diseases at this location

Fulminant hepatic failure/hemorrhagic fever in Amazon Basin: historical review, hepatic damage patterns and etiological diagnosis.

A presente análise das três séries históricas, compondo um total de 42 casos de hepatopatias fulminantes da região Amazônica, teve por objetivos o estudo de aspectos morfológicos e imuno-histoquímicos no diagnóstico diferencial entre febre amarela (FA), hepatite de Lábrea (HL) e de outras entidades. Visou, ainda, aprimorar o conhecimento de aspectos da morfogênese da morte hepatocelular, de eventual fibrose, relacionando-as aos padrões de regeneração e de lesões vasculares, conforme recentemente descrito na gênese de hepatopatias crônicas. Dentre o extenso painel de critérios histológicos aqui estudados, os padrões de morte hepatocelular e sua distribuição, incluindo corpos apoptóticos medio-zonais, assim como a balonização foram os achados mais característicos da FA, enquanto as células em mórula foram o principal achado na HL. Dezenove casos bem caracterizados (10 FA e 9 HL) foram então submetidos a estudos imuno-histoquímicos para a detecção dos antígenos da FA, AgHBs e antígeno do vírus da hepatite D (VHD), sendo então demonstrado que, em ambas as doenças, mas principalmente na HL, flebite, principalmente de ramos da veia porta, foi evidente e deve ter tido participação na patogênese do dano hepático, com extensa extinção parenquimatosa hepática e aproximação de espaços porta. O padrão de regeneração também foi marcante: nos casos de FA, um elevado índice de proliferação celular foi observado enquanto que, na HL, multinucleações e transformação pseudoacinar, associadas a depósitos portais de colágeno do tipo I e de fibras elásticas, foram encontrados. Concluindo, a pesquisa imuno-histoquímica de antígenos virais permitiu a caracterização etiológica dos casos destas importantes séries históricas de hepatopatias fulminantes da Amazônia, mesmo em amostras arquivadas em parafina por até sete décadas. Permitiu, ainda, o relato original de cinco casos de possível superposição de infecção pelos vírus da FA, VHB e/ou VHD. Dentre os aspectos histopatológicos, o quadro dominante na FA fulminante incluiu apoptose medio-zonal associada com flebite portal e um alto índice de proliferação celular, em pacientes sem evidência de dano hepático prévio. Por outro lado, a HL fulminante mostrou extensa necrose lítica de hepatócitos, associada à flebite portal e de veia hepática e à presença de células em mórula, em pacientes com evidências morfológicas de doença hepática crônica.This study aimed at assessing morphological and immunohistochemical aspects useful for the differential diagnosis of yellow fever (YF), Labrea hepatitis (LH) and other entities by revisiting 42 fulminant hepatic failure cases, from three historical series from Amazon Basin. Additional studies were performed aiming at further understanding the morphogenesis of hepatocelular death, in relation to regeneration and fibrosis patterns and to vascular lesions, as recently described in chronic hepatic diseases. Among the extensive panel of histological criteria studied, liver cell death pattern and distribution, including midzonal apoptotic bodies, as well as hepatocelular ballooning degeneration were YF most characteristic findings, while morula cells were the major hint for LH. Five cases were herein suggested as coinfected with YF, HBV and/or HDV, a finding not previously reported. Nineteen well characterized cases (10 YF and 9 LH) were further submitted to immunohistochemical studies for YF antigen, HBsAg and Delta virus Ag. In both diseases, but mainly in LH, phlebitis, mainly of portal vein branches, was evident and closely related to the degree of hepatocellular damage, with severe hepatic parenchymal extinction and portal tract approximation. Regeneration pattern was also remarkable: in YF cases, a high hepatocellular proliferative index was detected whereas in LH, multinucleation and pseudo-acinar transformation, associated with portal type I collagen and elastic fiber deposition were found. In conclusion, immunohistochemical viral antigen detection yielded further etiological characterization of these important historical cases of fulminant hepatic failure from Amazon Basin, even in paraffin samples stored for up to seven decades. YF morphology depicted midzonal apoptosis, portal phlebitis and a high hepatocellular proliferative index, in patients without evidence of previous hepatic injury. On the other hand, fulminant LH showed extensive lytic hepatocellular necrosis, portal and hepatic vein phlebitis and the presence morula cells, in patients with morphological evidences of chronic liver disease

Primary cutaneous follicle center lymphoma

Cutaneous lymphomas are classified according to their cellular origin into T-cell lymphoma and B-cell lymphoma. The annual incidence rate is 0.3 per 100,000 population. We report a case of a 56-year-old male patient who presented with a two-month history of nodules of varying sizes, some ulcerated, on the face, abdomen, and upper limbs. Histopathological examination and immunohistochemical study confirmed the diagnosis of primary cutaneous centrofollicular lymphoma. Studies have shown an increased incidence of non-Hodgkin lymphomas in the last decade. We report an infrequent case that should be kept as a differential diagnosis of patients with nodules and cutaneous papules.PIRES, C.A.A. Universidade Federal do Par

Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus). I. Virologic, biochemical, and immunologic studies

University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.University of Texas Medical Branch. Department of Pathology. Center for Tropical Diseases. Galveston, USA.This report describes the clinical laboratory findings in golden hamsters experimentally infected with yellow fever (YF) virus. An accompanying paper describes the pathologic findings. Following intraperitoneal inoculation of a virulent strain of YF virus, hamsters developed a high-titered viremia (up to 109/mL) lasting 5–6 days and abnormal liver function tests. YF hemagglutination–inhibiting antibodies appeared 4 or 5 days after infection, often while viremia was still present. The mortality rate in YF-infected hamsters was variable, depending on the virus strain and the age of the animals. Clinical and pathologic changes in the infected hamsters were very similar to those described in experimentally infected macaques and in fatal human cases of YF, which indicates that the golden hamster may be an excellent alternative animal model, in place of nonhuman primates, for research on the pathogenesis and treatment of YF and other viscerotropic flavivirus diseases

Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate

Background: Prostate cancer represents 3.8% of cancer deaths worldwide. For most prostate cancer cells to grow, androgens need to bind to a cellular protein called the androgen receptor (AR). This study aims to demonstrate the expression of five microRNAs (miRs) and its influence on the AR formation in patients from the northern region of Brazil. Material and Methods: Eighty-four tissue samples were investigated, including nodular prostatic hyperplasia (NPH) and acinar prostatic adenocarcinoma (CaP). Five miRs (27a-3p, 124, 130a, 488-3p, and 506) were quantified using the TaqMan® Real Time PCR method and AR was measured using Western blotting. Results: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples. Conversely, in the CaP cases, higher levels of miR 27a-3p and AR were observed. Conclusion: In the future, these microRNAs may be tested as markers of CaP at the serum level. The relative expression of AR was 20% higher in patients with prostate cancer, which suggests its potential as a biomarker for prostate malignancy