Weak scale from Planck scale -- Mass Scale Generation in Classically Conformal Two Scalar System --

In the standard model, the weak scale is the only parameter with mass dimensions. This means that the standard model itself can not explain the origin of the weak scale. On the other hand, from the results of recent accelerator experiments, except for some small corrections, the standard model has increased the possibility of being an effective theory up to the Planck scale. From these facts, it is naturally inferred that the weak scale is determined by some dynamics from the Planck scale. In order to answer this question, we rely on the multiple point criticality principle as a clue and consider the classically conformal $\mathbb{Z}_2\times \mathbb{Z}_2$ invariant two scalar model as a minimal model in which the weak scale is generated dynamically from the Planck scale. This model contains only two real scalar fields and does not contain any fermions and gauge fields. In this model, due to Coleman-Weinberg-like mechanism, one scalar field spontaneously breaks the $\mathbb{Z}_2$ symmetry with a vacuum expectation value connected with the cutoff momentum. We investigate this using the 1-loop effective potential, renormalization group and large N limit. We also investigate whether it is possible to reproduce the mass term and vacuum expectation value of the Higgs field by coupling this model with the standard model in the Higgs portal framework. In this case, the one scalar field that does not break $\mathbb{Z}_2$ can be a candidate for dark matter, and have a mass of about several TeV in appropriate parameters. On the other hand, the other scalar field breaks $\mathbb{Z}_2$ and has a mass of several tens of GeV. These results can be verified in near future experiments.Comment: 41 pages, 9 figures, minor mistakes in Section VI.B and typos correcte

Large N Analysis of TTˉT\bar{T}-deformation and Unavoidable Negative-norm States

We study non-perturbative quantum aspects of $T\bar{T}$-deformation of a free $O(N)$ vector model by employing the large $N$ limit. It is shown that bound states of the original field appear and inevitably become negative-norm states. In particular, the bound states can be regarded as the states of the conformal mode in a gravitational theory, where the Liouville action is induced with the coefficient proportional to the minus of central charge. To make the theory positive-definite, some modification is required so as to preserve diffeomorphism invariance due to the Faddeev-Popov ghosts with a negative central charge.Comment: 1+20 pages, 1 figur

Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy

We investigated the clinical efficacy and safety of tocilizumab (a humanized anti-IL-6 receptor antibody) monotherapy in active rheumatoid arthritis (RA) patients with an inadequate response to low dose methotrexate (MTX). In a multicenter, double-blind, randomized, controlled trial, 125 patients were allocated to receive either tocilizumab 8 mg/kg every 4 weeks plus MTX placebo (tocilizumab group) or tocilizumab placebo plus MTX 8 mg/week (control group) for 24 weeks. The clinical responses were measured using the American College of Rheumatology (ACR) criteria and the Disease Activity Score in 28 joints. Serum vascular endothelial growth factor (VEGF) levels were also monitored. At week 24, 25.0% in the control group and 80.3% in the tocilizumab group achieved ACR20 response. The tocilizumab group showed superior ACR response criteria over control at all time points. Additionally, serum VEGF levels were significantly decreased by tocilizumab treatment. The overall incidences of adverse events (AEs) were 72 and 92% (serious AEs: 4.7 and 6.6%; serious infections: 1.6 and 3.3%) in the control and the tocilizumab groups, respectively. All serious adverse events improved by adequate treatment. Tocilizumab monotherapy was well tolerated and provided an excellent clinical benefit in active RA patients with an inadequate response to low dose MTX

Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS

ObjectivesThe purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging.BackgroundAlthough previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics.MethodsProspective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months.ResultsGrayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.033), whereas no change was observed in the diet-only patients (48.7 ± 10.4%, 50.4 ± 11.8%; p = NS). IB-IVUS identified significant reductions in the percentage lipid volume index over time (34.9 ± 12.2%, 28.2 ± 7.5%; p = 0.020); no change was observed in the diet-treated group (31.0 ± 10.7%, 33.8 ± 12.4%; p = NS). While OCT demonstrated a significant increase in fibrous cap thickness (140 ± 42 μm, 189 ± 46 μm; p = 0.001), such changes were not observed in the diet-only group (140 ± 35 μm, 142 ± 36 μm; p = NS). Differences in the changes in the percentage lipid volume index (−6.8 ± 8.0% vs. 2.8 ± 9.9%, p = 0.031) and fibrous cap thickness (52 ± 32 μm vs. 2 ± 22 μm, p < 0.001) over time between the pitavastatin and diet groups were highly significant.ConclusionsStatin treatment induces favorable plaque morphologic changes with an increase in fibrous cap thickness, and decreases in both percentage plaque and lipid volume indexes

Preoperative multidisciplinary treatment with hyperthermia for soft tissue sarcoma

We report the results of phase I/II studies of preoperative multidisciplinary treatment of 14 patients with soft tissue sarcoma using hyperthermia from November 1990 to April 1995. The preoperative treatment was conducted with thermo-radio-chemotherapy in 11 cases of stage III, and with thermo-radiotherapy as well as thermo-chemotherapy in three cases of stages I and II. Hyperthermia was carried out twice a week with totals ranging from 4 to 14 times (average: 8.4 times); each session lasted 60min. Radiotherapy was administered four or five times per week, and the dose was 1.8 2Gy/fraction, with a total of 30-40Gy in a four week period. Chemotherapy was mainly in the form of MAID regimen (2-mercaptoethanesulphonic acid (mesna), adriamycin, ifosfamide and dacarbazine). The tumors were surgically resected in all patients after completing the preoperative treatment. The efficacy rate, as expressed by the percentage of either tumors in which reduction rate was 50% or more, or tumors for which post-treatment contrast enhanced CT image revealed low density volumes occupying 50% or more of the total mass, was 71 % (ten of the 14 tumors). The mean tumor necrosis rate in the resected specimens was 78%. The tumor necrosis rate was significantly high (P &#60; 0.05) in patients whose Time &#8805; 42°C was of long duration. Postoperative complications were observed in six patients; among these, two patients developed wound infection that required surgical treatment as a complication of surgery performed in the early stage following the preoperative treatment. After a mean postoperative follow-up of 27 months, distant metastasis occurred in four patients resulting in three fatalities. The three-year cumulative survival rate was 64.3%. No local recurrence was observed in any patient during the follow-up, thus confirming our hypothesis that preoperative multidisciplinary treatment has an excellent local efficacy. We think that it would be valuable to conduct, at many facilities, phase III studies on the treatment of soft tissue sarcoma by a combination of surgery and preoperative multidisciplinary treatment using hyperthermia, paying close attention to the interval between these two modalities.</p

Identification of Early Pleistocene tephras in the Fuchu core, Musashino Uplands, Tokyo

Three widespread Early Pleistocene tephras were identified in a sediment core drilled at Fuchu in the central part of the Musashino Uplands of the West Kanto Plain, the central Japanese Islands. Characteristic properties such as geochemical composition and refractive indices of glass shards correlate these unknown tephras to three well-characterized tephras formed by calderaforming eruptions. Ebs-Fkd (1.70 Ma), Nyg (1.75 Ma) and Sgn-Kd44 (2.0-1.8 Ma) tephras, all inthe Kazusa Group, early Quaternary strata, are compared to Fuchu core samples and other boring cores from the Musashino Uplands area. Changes in altitudes of those tephras found in other cores under the upland reveal changes to the Kazusa Group’s sedimentary environment and landform at the time of the tephra’s deposition