Differential effects of socioeconomic status on working and procedural memory systems

While prior research has shown a strong relationship between socioeconomic status (SES) and working memory performance, the relation between SES and procedural (implicit) memory remains unknown. Convergent research in both animals and humans has revealed a fundamental dissociation, both behaviorally and neurally, between a working memory system that depends on medial temporal-lobe structures and the dorsal lateral prefrontal cortex (DLPFC) vs. a procedural memory system that depends on the basal ganglia. Here, we measured performance in adolescents from lower- and higher-SES backgrounds on tests of working memory capacity (complex working memory span) and procedural memory (probabilistic classification) and their hippocampal, DLPFC, and caudate volumes. Lower-SES adolescents had worse working memory performance and smaller hippocampal and DLPFC volumes than their higher-SES peers, but there was no significant difference between the lower- and higher-SES groups on the procedural memory task or in caudate volumes. These findings suggest that SES may have a selective influence on hippocampal-prefrontal-dependent working memory and little influence on striatal-dependent procedural memory

Ear, tail and skin lesions vary according to different production flows in a farrow-to-finish pig farm

peer-reviewedBackground Pig performance and risk of disease are associated with production flow. Given the link between health and welfare, it is likely that animal welfare indicators are also associated with production flow. This study investigated the association between production flow and tail, ear and skin lesions on a farm with a purported ‘all-in/all-out’ policy. This was an observational study whereby pigs were managed according to routine farm practice. A total of 1,016 pigs born within 1 week from the same batch were followed through the production stages and the presence or absence of welfare indicators was recorded at 4, 7, 9, 12, 16 and 24 weeks of age. Three production flows were retrospectively identified: flow 1 = ‘normal’ pigs that advanced through the production stages together ‘on time’, flow 2 = pigs delayed from advancing from the 1st to the 2nd nursery stage by 1 week and flow 3 = pigs delayed from advancing through the production stages by > 1 week. A nested case control design was applied by matching pigs by sow parity, number of born alive and birth weight. Results The presence of ear lesions was 4.5 less likely in pigs in flow 2 and 2.9 times less likely in pigs in flow 3 (P < 0.001) compared to pigs in flow 1. Pigs in flow 3 were 2.2 more likely to have tail and 1.6 times more likely to have ear lesions (P < 0.001) compared to pigs in flow 2. Pigs in flow 2 were less likely to have tail lesions compared with pigs in flow 1 (P < 0.05). Differences between production flows for the risk of skin lesions varied according to age (P < 0.05). Conclusion All production flows were associated with a high risk of lesions which raises concerns for pig welfare. However, risks for ear, tail and skin lesions varied according to each production flow likely due to the specific management practices inherent to each flow. Results from this study could be used to modify existing management practices, thus leading to improvements in animal welfare and possibly performance in intensive pig systems

Delaying pigs from the normal production flow is associated with health problems and poorer performance

peer-reviewedBackground Delaying pigs from advancing through the production stages could have a negative impact on their health and performance. The objective of this study was to investigate the possible implications of delaying pigs from the normal production flow on pig health and performance in a farrow-to-finish commercial farm with a self-declared All-In/All-Out (AIAO) management. Results Three flows of pigs were defined, flow 1 (i.e. pigs that followed the normal production flow; 8 weeks in the nursery stage, 4 weeks in the growing stage and 8 weeks in the finisher stage), flow 2 (i.e. pigs delayed 1 week from advancing to the next production stage) and flow 3 (i.e. pigs delayed >1 week from advancing to the next production stage). Flow 3 included higher proportions of pigs from first parity sows and of lighter birth weights. When the 3 flows were matched by parity and birth weight, pigs in flow 2 were 3.8 times more likely to be lame prior to slaughter compared with pigs in flow 1. Similarly, pigs in flow 3 were more likely to be lame prior to slaughter, 4.5 times more likely to present pleurisy, 3.3 times more like to present pericarditis and 4.3 times more likely to have their heart condemned at slaughter compared with pigs in flow 1. Additionally, carcasses from pigs in flow 3 were 10 kg lighter compared with carcasses from pigs in flow 1. Conclusion Delayed pigs were more affected by disease and were lighter at slaughter. Besides animal welfare issues, these findings could represent considerable economic loses for pig producers. In practice, delaying pigs from the normal production flow translates into higher feeding costs, increase number of days to slaughter and increased labour requirements reducing production efficiency for the pig operation. In farrow-to-finish farms an ‘all-forward’ policy (i.e. no pig is left behind from stage to stage and a split marketing approach is applied when sending pigs to slaughter) might be more easily adhered to.This project was supported by the Irish Department of Agriculture, Food and the Marine (DAFM) grant 14/S/832. Alessia Diana was supported by the Teagasc Walsh Fellowship Fund

Tsunami awareness and preparedness in Aotearoa New Zealand:The evolution of community understanding

After catastrophic events such as the 2004 Indian Ocean tsunami and the 2011 Great East Japan earthquake and tsunami there is a clear need for vulnerable countries like Aotearoa New Zealand to get prepared for tsunami. In the last ten years, the New Zealand government initiated major efforts to raise awareness of tsunami risk among coastal residents. This study explores tsunami awareness, preparedness, and evacuation intentions among residents of the East Coast of the North Island in a 2015 survey. The ten chosen locations also participated in a tsunami survey in 2003, with results demonstrating that tsunami awareness rose in the twelve years between the surveys. The 2015 survey also included questions on preparedness and intended action. Even though coastal residents know they live in a tsunami prone area, preparedness is relatively low and high expectations of a formal warning remain, even for a local source tsunami scenario. Furthermore, survey respondents had unrealistic ideas of evacuation procedures. When asked about their evacuation intentions, respondents intended to undertake a number of different actions before evacuating their homes, which could cause significant delays in the evacuation process. Most respondents were also reluctant to evacuate on foot and prefer using their vehicles instead, which could create dangerous traffic congestion. These surveyed intentions are consistent with a study of actual evacuation behaviours in the subsequent 2016 Kaikōura earthquake and tsunami, providing validation for the survey indicators. This paper identifies the procedures least understood by the public and offers some solutions to improve tsunami preparedness.</p

Early stressful experiences are associated with reduced neural responses to naturalistic emotional and social content in children

How do children’s experiences relate to their naturalistic emotional and social processing? Because children can struggle with tasks in the scanner, we collected fMRI data while 4-to-11-year-olds watched a short film with positive and negative emotional events, and rich parent-child interactions (n = 70). We captured broad, normative stressful experiences by examining socioeconomic status (SES) and stressful life events, as well as children’s more proximal experiences with their parents. For a sub-sample (n = 30), parenting behaviors were measured during a parent-child interaction, consisting of a picture book, a challenging puzzle, and free play with novel toys. We characterized positive parenting behaviors (e.g., warmth, praise) and negative parenting behaviors (e.g., harsh tone, physical control). We found that higher SES was related to greater activity in medial orbitofrontal cortex during parent-child interaction movie events. Negative parenting behaviors were associated with less activation of the ventral tegmental area and cerebellum during positive emotional events. In a region-of-interest analysis, we found that stressful life events and negative parenting behaviors were associated with less activation of the amygdala during positive emotional events. These exploratory results demonstrate the promise of using movie fMRI to study how early experiences may shape emotional, social, and motivational processes

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers.

Clinical and neuropathological characteristics associated with G4C2 repeat expansions in chromosome 9 open reading frame 72 (C9ORF72), the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, are highly variable. To gain insight on the molecular basis for the heterogeneity among C9ORF72 mutation carriers, we evaluated associations between features of disease and levels of two abundantly expressed "c9RAN proteins" produced by repeat-associated non-ATG (RAN) translation of the expanded repeat. For these studies, we took a departure from traditional immunohistochemical approaches and instead employed immunoassays to quantitatively measure poly(GP) and poly(GA) levels in cerebellum, frontal cortex, motor cortex, and/or hippocampus from 55 C9ORF72 mutation carriers [12 patients with ALS, 24 with frontotemporal lobar degeneration (FTLD) and 19 with FTLD with motor neuron disease (FTLD-MND)]. We additionally investigated associations between levels of poly(GP) or poly(GA) and cognitive impairment in 15 C9ORF72 ALS patients for whom neuropsychological data were available. Among the neuroanatomical regions investigated, poly(GP) levels were highest in the cerebellum. In this same region, associations between poly(GP) and both neuropathological and clinical features were detected. Specifically, cerebellar poly(GP) levels were significantly lower in patients with ALS compared to patients with FTLD or FTLD-MND. Furthermore, cerebellar poly(GP) associated with cognitive score in our cohort of 15 patients. In the cerebellum, poly(GA) levels similarly trended lower in the ALS subgroup compared to FTLD or FTLD-MND subgroups, but no association between cerebellar poly(GA) and cognitive score was detected. Both cerebellar poly(GP) and poly(GA) associated with C9ORF72 variant 3 mRNA expression, but not variant 1 expression, repeat size, disease onset, or survival after onset. Overall, these data indicate that cerebellar abnormalities, as evidenced by poly(GP) accumulation, associate with neuropathological and clinical phenotypes, in particular cognitive impairment, of C9ORF72 mutation carriers

No Place Like Home: Examining a Bilingual-Bicultural, Self-Run Substance Abuse Recovery Home for Latinos

Latinos often do not seek substance abuse services, and this might be correlated to the lack of culturally-modified substance abuse treatment approaches. Oxford House is the largest self-help residential recovery program in the U.S., yet few Latinos are among their current residents. In an effort to change this, bilingual-bicultural recovery homes were recently developed for Latinos. This article describes the process in opening these bilingual-bicultural houses and how sociocultural factors such as the family, simpatía, and gender roles impacted the living environment of these houses. In addition, language is highlighted as a key factor to the comfort and success of Latinos living in Oxford Houses. Based on these experiences, the article addresses several obstacles/barriers that impacted this process and possible feasible solutions to these challenges. One challenge is the Latino family system. While this may provide a supportive, cost-effective option for some; it can also perpetuate a cycle of codependence and substance abuse

T cell memory revisited using single telomere length analysis

The fundamental basis of T cell memory remains elusive. It is established that antigen stimulation drives clonal proliferation and differentiation, but the relationship between cellular phenotype, replicative history, and longevity, which is likely essential for durable memory, has proven difficult to elucidate. To address these issues, we used conventional markers of differentiation to identify and isolate various subsets of CD8+ memory T cells and measured telomere lengths in these phenotypically defined populations using the most sensitive technique developed to date, namely single telomere length analysis (STELA). Naive cells were excluded on the basis of dual expression of CCR7 and CD45RA. Memory subsets were sorted as CD27+CD45RA+, CD27intCD45RA+, CD27−CD45RA+, CD27+CD45RAint, CD27−CD45RAint, CD27+CD45RA−, and CD27−CD45RA− at >98% purity. The shortest median telomere lengths were detected among subsets that lacked expression of CD45RA, and the longest median telomere lengths were detected among subsets that expressed CD45RA. Longer median telomere lengths were also a feature of subsets that expressed CD27 in compartments defined by the absence or presence of CD45RA. Collectively, these data suggested a disconnect between replicative history and CD8+ memory T cell differentiation, which is classically thought to be a linear process that culminates with revertant expression of CD45RA

The 2016 Model of The Clinical Practice of Emergency Medicine

Emergency medicine (EM) has a scientifically derived and commonly accepted description of the domain of its clinical practice. That document, “The Model of the Clinical Practice of Emergency Medicine” (EM Model), was developed through the collaboration of six organizations: the American Board of Emergency Medicine (ABEM), the administrative organization for the project, the American College of Emergency Physicians (ACEP), the Council of Emergency Medicine Residency Directors (CORD), the Emergency Medicine Residents\u27 Association (EMRA), the Residency Review Committee for Emergency Medicine (RRC-EM), and the Society for Academic Emergency Medicine (SAEM). Development of the EM Model was based on an extensive practice analysis of the specialty. The practice analysis relied on both empiric data gathered from actual emergency department visits and several expert panels (1). The resulting product was first published in 2001, and has successfully served as the common source document for all EM organizations (2,3). One of its strengths is incorporating the reality that EM is a specialty driven by symptoms not diagnoses, requiring simultaneous therapeutic and diagnostic interventions