Multi-state model of non-AIDS event (NAE) development and all-cause mortality.

<p>Three possible states are considered: (1) alive without NAE, (2) alive with NAE, (3) death. Number (%) of patients for each transition; for transition 2→3 (death after NAE), the percent is calculated using the number of patients who previously reached state 2 (Alive with NAE).</p

Incidence and outcomes of non-AIDS events classified according to severity in 8,789 people living with HIV (27,520 person-years of follow-up).

<p>Incidence and outcomes of non-AIDS events classified according to severity in 8,789 people living with HIV (27,520 person-years of follow-up).</p

Predicted probabilities before and after non-AIDS event (NAE) development in a high risk patient (male, aged > 50 years, CD4< 200 cell/mm3 and plasma HIV1-RNA >100.000 copies/ml at engagement, IDU transmission category, previous AIDS events, cohort inclusion before 2009, hepatitis C coinfection, CD4 cell at NAE development < 500 cell/mm3 and plasma HIV1-RNA at NAE above the limit of detection).

<p>The probabilities are stacked; the distance between two curves represents the probability, associated with the text in figure.</p

Results of adjusted multi-state modelling prognostic factor’s effect on incident non-AIDS event (NAE) development, and on death either without or after first NAE in 8,679 people living with HIV (27,117 person-years of follow-up).

<p>Data are provided for all categories of NAEs and by severity category.</p