Implementación de un Sistema de Información como un nuevo canal de comercialización de gas doméstico en Cuenca, Ecuador

La distribución de gas doméstico en Cuenca enfrenta desafíos en eficiencia, comunicación, tiempos de entrega y contaminación acústica. Los métodos tradicionales utilizados, como la canción de gas a alto volumen y las comunicaciones telefónicas, generan demoras, falta de información precisa, dificultades para contactar a los repartidores y recorridos de entrega ineficientes. Este trabajo de titulación propone una solución informática para superar estas problemáticas. El objetivo principal es desarrollar un sistema de información que sirva como un canal alternativo para la distribución de gas doméstico en la ciudad de Cuenca. Para ello, se realizó un diagnóstico de la distribución de gas doméstico en la ciudad mediante encuestas a consumidores y repartidores. Esto ayudó a identificar los problemas y necesidades de los actores involucrados. Con esta información, se estableció un marco conceptual y tecnológico que sirvió como base para el desarrollo del sistema de información. El sistema desarrollado se compone de cuatro aplicaciones: una para los consumidores, otra para los repartidores, una aplicación web de administración y una aplicación de backend que conecta todas las anteriores. Finalmente, se llevó a cabo una evaluación de usabilidad con un grupo de usuarios seleccionados para verificar la efectividad y satisfacción al utilizar el sistema, esto a través de cuestionarios y tareas específicas. Los resultados de la evaluación demostraron una excelente usabilidad y satisfacción por parte de los usuarios. Esta retroalimentación validó el diseño y desarrollo del sistema de información, y se utilizó para realizar ajustes y mejoras adicionalesThe distribution of domestic gas in Cuenca faces challenges in efficiency, communication, delivery times, and noise pollution. Traditional methods, such as high-volume gas songs and telephone communications, result in delays, lack of accurate information, difficulties in contacting delivery men, and inefficient delivery routes. This thesis proposes an IT solution to overcome these issues. The main objective is to develop an information system that serves as an alternative channel for domestic gas distribution in the city of Cuenca. To achieve this, a diagnosis of domestic gas distribution in the city was conducted through surveys with consumers and delivery men. This helped identify the problems and needs of the stakeholders involved. Based on this information, a conceptual and technological framework was established as the foundation for the development of the information system. The developed system consists of four applications: one for consumers, another for delivery men, a web-based administration application, and a backend application that connects them all. Finally, a usability evaluation was carried out with a selected group of users to assess the effectiveness and satisfaction in using the system. This was done through questionnaires and specific tasks. The evaluation results demonstrated excellent usability and user satisfaction. This feedback validated the design and development of the information system and was utilized to make further adjustments and improvements.0000-0002-5125-82340000-0003-3004-102

Estudio de la relación curricular entre el bachillerato y el 1er año de la carrera de Administración Pública de la Universidad Central del Ecuador.

El presente estudio busca establecer estratégicamente la relación existente entre la currí­cula del bachillerato y su articulación con los componentes de la Carrera de Administración Pública de la Universidad Central, en lo que al primer año se refiere; Para lo cual se determina las inexactitudes en las diferentes áreas del conocimiento a fin de proporcionar las competencias necesarias para que el bachiller tenga la sapiencia y habilidades requeridas para cumplir con las exigencias que el primer año de universidad lo requiere.Los cambios realizados en las polí­ticas educativas del paí­s hacen ineludible estudiar las necesidades de la Licenciatura en Administración Pública de la Facultad de Ciencias Administrativas de la Universidad Central del Ecuador, respecto a la relación curricular entre el bachillerato y el primer año de Universidad. Para este efecto se determinaron    las inexactitudes en las diferentes áreas del conocimiento a fin de proporcionar las competencias necesarias para que el bachiller tenga la sapiencia y habilidades requeridas para cumplir con las exigencias que el primer año de bachillerato las requiere.Se aplicó el método de investigación   deductivo, y  se realizó  un   enfoque cuantitativo y cualitativo que permitió efectuar un estudio exploratorio analizar la importancia de una formación académica en el ámbito de la Administración Pública, con pensamiento crí­tico y argumentativo.

Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer’s disease

In Alzheimer's disease (AD) amyloid-beta (A beta) deposits may cause impairments in choroid plexus, a specialised brain structure which forms the blood-cerebrospinal fluid (CSF) barrier. We previously carried out a mass proteomic-based study in choroid plexus from AD patients and we found several differentially regulated proteins compared with healthy subjects. One of these proteins, annexin A5, was previously demonstrated implicated in blocking A beta -induced cytotoxicity in neuronal cell cultures. Here, we investigated the effects of annexin A5 on A beta toxicity in choroid plexus. We used choroid plexus tissue samples and CSF from mild cognitive impairment (MCI) and AD patients to analyse A beta accumulation, cell death and annexin A5 levels compared with control subjects. Choroid plexus cell cultures from rats were used to analyse annexin A5 effects on A beta -induced cytotoxicity. AD choroid plexus exhibited progressive reduction of annexin A5 levels along with progressive increased A beta accumulation and cell death as disease stage was higher. On the other hand, annexin A5 levels in CSF from patients were found progressively increased as the disease stage increased in severity. In choroid plexus primary cultures, A beta administration reduced endogenous annexin A5 levels in a time-course dependent manner and simultaneously increased annexin A5 levels in extracellular medium. Annexin A5 addition to choroid plexus cell cultures restored the A beta -induced impairments on autophagy flux and apoptosis in a calcium-dependent manner. We propose that annexin A5 would exert a protective role in choroid plexus and this protection is lost as A beta accumulates with the disease progression. Then, brain protection against further toxic insults would be jeopardised

ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet

The methylation levels of ZNF577 in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of ZNF577 depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of ZNF577 of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [n = 90; n = 64 (71.1%) overweight/obesity and n = 26 (28.9%) normal-weight] and paired tumor tissue biopsies (n = 8 breast cancer patients with obesity; n = 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the Sociedad Espanola de Nutricion Comunitaria. The methylation levels of ZNF577 were correlated between paired leukocytes and breast tumor biopsies (r = 0.62; p = 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity (p = 0.002) and postmenopausal patients (p = 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of ZNF577 methylation were also found in women with greater adherence to the Mediterranean diet (p = 0.017) or specific foods. Relevantly, the methylation levels of ZNF577 showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72; p = 0.016]. In conclusion, the association between methylation of ZNF577 and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of ZNF577 methylation in the association between breast cancer, adiposity and dietary patterns

Galician consensus on management of cardiotoxicity in breast cancer: risk factors, prevention, and early intervention

This Galician consensus statement is a joint oncologists/cardiologists initiative indented to establish basic recommendations on how to prevent and to manage the cardiotoxicity in breast cancer with the aim of ensuring an optimal cardiovascular care of these patients. A clinical screening of the patients before treatment is recommended to stratify them into a determined risk group based on their intrinsic cardiovascular risk factors and those extrinsic arose from breast cancer therapy, thereby providing individualized preventive and monitoring measures. Suitable initial and ongoing assessments for patients with low and moderate/high risk and planned treatment with anthracyclines and trastuzumab are given; also, measures aimed at preventing and correcting any modifiable risk factor are pointed out .TEVA Farma Españ

CTCs expression profiling for advanced breast cancer monitoring

The study of circulating tumor cells (CTCs) has a huge clinical interest in advance and metastatic breast cancer patients. However, many approaches are biased by the use of epithelial markers, which underestimate non-epithelial CTCs phenotypes. CTCs enumeration provides valuable prognostic information; however, molecular characterization could be the best option to monitor patients throughout the disease since it may provide more relevant clinical information to the physicians. In this work, we aimed at enumerating and performing a molecular characterization of CTCs from a cohort of 20 patients with metastatic breast cancer (MBC), monitoring the disease at different time points of the therapy, and at progression when it occurred. To this end, we used a CTC negative enrichment protocol that allowed us to recover a higher variety of CTCs phenotypes. With this strategy, we were able to obtain gene expression data from CTCs from all the patients. In addition, we found that high expression levels of PALB2 and MYC were associated with a worse outcome. Interestingly, we identified that CTCs with an EpCAM(high)VIM(low)ALDH1A1(high) signature showed both shorter overall survival (OS) and progression-free survival (PFS), suggesting that CTCs with epithelial-stem features had the most aggressive phenotype

Rents, knowledge and neo-structuralism: transforming the productive matrix in Ecuador

This paper explores the relationship between ground rent, production and knowledge in Ecuador’s neo-structuralist, state-led project to transform the productive matrix. Based upon insights from the Marxian approach to the critique of political economy, we interrogate how neo-structuralism has conceptualised the relationship between ‘natural resource income’ and ‘knowledge-based’ economic development. The paper argues that a rent-theoretical perspective, which takes seriously the regional unfolding of uneven geographical development in Latin America, can highlight the limits of a national development plan conceived according to the logic of Schumpeterian efficiency. In doing so, the paper identifies the contradictory relationship between natural resource exports, state-led ‘knowledge’-based development and capital accumulation. On this basis the paper offers a historically and empirically informed critical analysis of selective import substitution industrialisation and vanguard science and technology strategies designed to transition Ecuador away from primary resource dependence

Aplicación de un censo poblacional en el AA.HH. Las Torres de San Borja- Moche -Trujillo– Perú

Resumen En este proyecto de responsabilidad social, realizado en el Asentamiento Humano Las Torres de San Borja en el Distrito de Moche, Provincia de Trujillo, Departamento la Libertad; se elaboró una encuesta dividida en 4 grupos de preguntas para la obtención de los resultados. El primer grupo desarrollado es sobre INFORMACIÓN GENERAL Y PROBLEMÁTICA que se encuentra en la zona. En el segundo grupo se obtiene información con respecto a la VIVIENDA, analizando el material de la estructura de éstas, así como los servicios básicos con los que cuentan. Como tercer grupo se desarrolla SALUD, en la cual se identifica los principales problemas de salud que aquejan a los pobladores. Por último, se desarrolla el cuarto grupo de preguntas el cual trata sobre EDUCACIÓN de sus pobladores y las oportunidades que pudieran tener los jóvenes para seguir estudiando. En la recolección de datos se obtuvo un muestreo de 75 familias de las 85 habitantes de la zona. El Censo Poblacional permite identificar la principal problemática del AA. HH. Las Torres de San Borja en cada uno de los ejes de desarrollo: educación, salud, recreación, transporte, economía, infraestructura, seguridad, habitad y vivienda, con el fin de determinar medidas eficaces que permitan mejorar la calidad de vida de sus pobladores. Así mismo, es la base del proyecto que busca evaluar y medir los resultados con el fin de ir mejorando su ejecución. El compromiso con el proyecto académico de responsabilidad social UNIONES, es el trabajo en conjunto como estudiantes de la Universidad Privada del Norte en coordinación con el Centro de Atención y Educación a la Familia (CAEF), así como la participación de los pobladores de la zona de intervención.Abstract In this social responsibility project, applied at the AA.HH. Torres de San Borja, in the District of Moche, Province of Trujillo, La Libertad; a poll was developed which was divided into 4 groups of questions to obtain the results. The first group of questions is about GENERAL INFORMATION AND PROBLEMATIC that is in the zone. In the second group, information is obtained regarding the HOUSING, analyzing the material of the structure of them, as well as the basic services the folks have. HEALTH is the subject of the third group of questions, which identifies the main health problems that people have. Finally, the fourth group of questions is developed about EDUCATION of its inhabitants and the opportunities that the young people could have to continue studying. In the collection of data, a sample of 75 families of the 85 inhabitants of the zone was obtained. The Population census allows identifying the main problem of AA. H H. Torres de San Borja in every factor of development: education, health, recreation, transport, economy, infrastructure, security, habitation and housing, in order to determine effective actions that allow improving the life quality of its inhabitants. Likewise, it is the base of a project that seeks to evaluate and measure the results in order to improve the execution of the actions determined. The commitment to the UNION project is to work together as UPN students in coordination with the Centro de Atención y Educación a la Familia (CAEF), as well as the participation of community resident

Ethics Committee experience during COVID-19 emergency. A brief report

La crisis sanitaria motivada por el COVID-19 hace necesaria la puesta en marcha, con celeridad, de investigaciones encaminadas a generar evidencias científicas que incidan en el control de sus devastadores efectos. Por ello, fue necesario realizar ajustes en la dinámica de trabajo de los Comités de Ética de la Investigación así como priorizar y agilizar la evaluación de los proyectos relacionados con dicha enfermedad. Este trabajo pretende analizar la actividad la actividad evaluadora del Comité de Ética de la Investigación con Medicamentos de Galicia (CEIm-G) durante dicho período de emergencia sanitaria. Se evaluaron 81 proyectos de investigación, 73 de ellos de ámbito autonómico (62 unicéntricos), 4 nacionales y 4 internacionales. En 57 proyectos el dictamen fue favorable, 4 fueron retirados por los promotores, en 6 no procedía dictamen y 14 no respondieron a las aclaraciones solicitadas hasta la fecha del cierre del estudio. La causas más frecuentes de solicitud de aclaraciones estaban relacionadas con la metodología y a continuación con la hoja de información al paciente y el consentimiento informado. También es imprescindible abordar los aspectos relacionados con la intimidad de los datos personales y las muestras y tener en cuenta la carga de trabajo de los investigadores. Como propuesta de mejora, consideramos que se debe incidir en una mayor coordinación entre los diferentes equipos de investigación para tratar de obtener resultados más robustos