Segmental and Tandem Duplications Driving the Recent NBS-LRR Gene Expansion in the Asparagus Genome

Garden asparagus is an important horticultural plant worldwide. It is, however, susceptible to a variety of diseases, which can affect the potential yield, spear quality, and lifespan of production fields. Screening studies have identified resistant germplasm. The genetic resistance is usually complex, and the genes underlying that resistance are still unknown. Most often, disease resistance is determined by resistance genes (R). The most predominant R-genes contain nucleotide binding site and leucine-rich repeat (NBS-LRR) domains. Using bioinformatics and data mining approaches, we identified and characterized 68 NBS predicted proteins encoded by 49 different loci in the asparagus genome. The NBS-encoding genes were grouped into seven distinct classes based on their domain architecture. The NBS genes are unevenly distributed through the genome and nearly 50% of the genes are present in clusters. Chromosome 6 is significantly NBS-enriched and one single cluster hosts 10% of the genes. Phylogenetic analysis points to their diversification into three families during their evolution. Recent duplications are likely to have dominated the NBS expansion with both tandem genes and duplication events across multiple chromosomes. Transcriptome sequencing data provided evidence for their transcription and tissue-specific expression. The total number of cis-regulatory elements as well as their relative positions within the NBS promoters suggests a complex transcriptional network regulating defense responses. Our study provides a strong groundwork for the isolation of candidate R-genes in garden asparagus

QTL Analysis of Morpho-Agronomic Traits in Garden Asparagus (Asparagus officinalis L.)

In order to understand the genetic control of quantitative agronomic traits in garden asparagus, we performed a quantitative trait loci (QTL) analysis. A population (n = 167) derived from a cross between a female and male plants was evaluated for morpho-agronomic traits over three years. Interval mapping (IM) and restricted multiple QTL mapping (rMQM) analysis was applied, and 18 QTLs were detected. QTLs were located in two linkage groups (LG): 5 in LG5 and 13 in LG6. The physical position of markers of both groups was mapped onto the reference genome through BLAST analysis. LG5 and LG6 match with chromosome 1 (sex-determining chromosome) and chromosome 5, respectively. Haplotypes of both chromosomes of the heterozygous parent and their progeny were obtained, and a bin map was developed. Bins were used to map the QTLs on the reference genome and to perform the association analysis with the morpho-agronomic traits. Two major and stable QTLs over the years (R2 > 10%) for number of stalk and earliness were mapped in the end of chromosome 1 into a bin that spans 3.25 Mb and includes the sex-determination locus. In chromosome 5, some QTLs were located in the center of chromosome for the year 2016. Branching is tightly regulated by both internal factors (such as plant hormones) and external factors (such as light conditions). QTLs for branching height and earliness were detected in a bin that spans 4.96 Mb. Functional annotation of genes within the two bins revealed candidate genes with potential roles in SA and light signaling and photomorphogenesis pathways that may be involved in branching and/or tillering. This is the first study providing the identification of genomic regions associated with yield-related morpho-agronomic traits in asparagus

Effects of glyphosate on microbial community structure and activity in two soils under olive plantations

Los herbicidas pueden alterar la estructura y el funcionamiento del suelo mediante efectos directos sobre varios componentes de su microbiota. Muchos autores han encontrado un efecto perjudicial del glifosato sobre la calidad del suelo y la diversidad microbiana. Sin embargo, la mayoría de los trabajos han sido realizados en sistemas de cultivos herbáceos y anuales y muy pocos en sistemas forestales o leñosos perennes. El objetivo del presente trabajo fue analizar el efecto a corto plazo de la aplicación de glifosato sobre parámetros microbiológicos generales y la estructura de las comunidades microbianas de suelos provenientes de lotes cultivados con olivo (Olea europaea L.). Realizamos un experimento de aplicación de distintas concentraciones de glifosato en dos tipos de suelo de olivar, con y sin historial de aplicación de pesticidas, y evaluamos distintas propiedades del suelo a lo largo de 55 días de incubación. En general, el impacto del glifosato sobre la microbiota fue mucho más importante en el suelo sin historial de aplicación de herbicida. En la mayoría de los parámetros analizados, el tratamiento con glifosato a la concentración recomendada a campo no se diferenció del tratamiento control. El cambio observado en la biomasa microbiana total no fue consistente. Sin embargo, en ambos suelos analizados, la aplicación de altas concentraciones de glifosato produjo un incremento significativo de las bacterias cultivables y de las bacterias Gram (-), estimada por medio de perfiles de ácidos grasos.Herbicides may alter soil ecosystems by a direct effect on selected component of soil microflora. Several authors reported a harmful effect of glyphosate on soil quality and microbial diversity. Most studies have been focused in the effect of annual extensive crops and a few have been done in perennial woody plantations. The aim of our study was to study the short-term effect of glyphosate application on microbiological parameters and microbial community structure under olive plantations. We applied different dosages of glyphosate to soils corresponding to two olive plantations, with and without history of pesticide application and evaluated a number of functional and structural parameters of soil biota throughout 55 days. In general, the soil without history of glyphosate application had a greater impact of glyphosate on with respect to the soil with history of glyphosate application. There was no consistent effect on total microbial biomass. However, the effect of glyphosate application at field rate was similar to control treatment. In both soils analyzed, glyphosate applied at elevated dosages increased cultivable bacteria and Gram (-) bacteria, as estimated by fatty acids profiles.Fil: Bórtoli, Paula V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Verdenelli, Romina Aylen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Conforto, Cinthia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronomicas; ArgentinaFil: Vargas Gil, Silvina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronomicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Meriles, Jose Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentin

Simulation Study for Designing a Dedicated Cardiac TOF-PET System

[EN] The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations for specific organs have been developed for improving detection effectiveness. Open geometries are always subject to distortion and artifacts in the reconstructed images. Therefore, the aim of this work is to determine the optimal geometry for a novel cardiac PET system that will be developed by our team, and determine the time resolution needed to achieve reasonable image quality for the chosen geometry. The proposed geometries consist of 36 modules. These modules are arranged in two sets of two plates, each one with different configurations. We performed Monte Carlo simulations with different TOF resolutions, in order to test the image quality improvement in each case. Our results show, as expected, that increasing TOF resolution reduces distortion and artifact effects. We can conclude that a TOF resolution of the order of 200 ps is needed to reduce the artifacts, to acceptable levels, generated in the simulated cardiac-PET open geometries.This project has been co-financed by the Spanish Government Grants TEC2016-79884-C2 and RTC-2016-5186-1, by the European Union through the European Regional Development Fund (ERDF) and by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (Grant Agreement No. 695536). The work of V.I. was supported by the Generalitat Valenciana APOSTD/2019/086 fellowship.Oliver-Gil, S.; Moliner, L.; Ilisie, V.; Benlloch Baviera, JM.; Rodríguez-Álvarez, M. (2020). Simulation Study for Designing a Dedicated Cardiac TOF-PET System. Sensors. 20(5):1-16. https://doi.org/10.3390/s20051311S116205Gaemperli, O., & Kaufmann, P. A. (2011). PET and PET/CT in cardiovascular disease. Annals of the New York Academy of Sciences, 1228(1), 109-136. doi:10.1111/j.1749-6632.2011.06030.xThackeray, J. T., & Bengel, F. M. (2018). Molecular Imaging of Myocardial Inflammation With Positron Emission Tomography Post-Ischemia. JACC: Cardiovascular Imaging, 11(9), 1340-1355. doi:10.1016/j.jcmg.2018.05.026Li, Z., Gupte, A. A., Zhang, A., & Hamilton, D. J. (2017). Pet Imaging and its Application in Cardiovascular Diseases. Methodist DeBakey Cardiovascular Journal, 13(1), 29. doi:10.14797/mdcj-13-1-29Juárez-Orozco, L. E., Tio, R. A., Alexanderson, E., Dweck, M., Vliegenthart, R., El Moumni, M., … Slart, R. H. J. A. (2017). Quantitative myocardial perfusion evaluation with positron emission tomography and the risk of cardiovascular events in patients with coronary artery disease: a systematic review of prognostic studies. European Heart Journal - Cardiovascular Imaging, 19(10), 1179-1187. doi:10.1093/ehjci/jex331Schelbert, H. R. (2009). Quantification of Myocardial Blood Flow: What is the Clinical Role? Cardiology Clinics, 27(2), 277-289. doi:10.1016/j.ccl.2008.12.009Knuuti, J., Kajander, S., Mäki, M., & Ukkonen, H. (2009). Quantification of myocardial blood flow will reform the detection of CAD. Journal of Nuclear Cardiology, 16(4), 497-506. doi:10.1007/s12350-009-9101-1Peng, H. (2015). Design study of a cardiac-dedicated PET system. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 779, 39-46. doi:10.1016/j.nima.2015.01.042Gonzalez, A. J., Sanchez, F., & Benlloch, J. M. (2018). Organ-Dedicated Molecular Imaging Systems. IEEE Transactions on Radiation and Plasma Medical Sciences, 2(5), 388-403. doi:10.1109/trpms.2018.2846745Moliner, L., Rodríguez-Alvarez, M. J., Catret, J. V., González, A., Ilisie, V., & Benlloch, J. M. (2019). NEMA Performance Evaluation of CareMiBrain dedicated brain PET and Comparison with the whole-body and dedicated brain PET systems. Scientific Reports, 9(1). doi:10.1038/s41598-019-51898-zAhmed, A. M., Tashima, H., Yoshida, E., Nishikido, F., & Yamaya, T. (2017). Simulation study comparing the helmet-chin PET with a cylindrical PET of the same number of detectors. Physics in Medicine and Biology, 62(11), 4541-4550. doi:10.1088/1361-6560/aa685cCho, Z.-H., Son, Y.-D., Kim, H.-K., Kwon, D.-H., Joo, Y.-H., Ra, J. B., … Kim, Y.-B. (2019). Development of Positron Emission Tomography With Wobbling and Zooming for High Sensitivity and High-Resolution Molecular Imaging. IEEE Transactions on Medical Imaging, 38(12), 2875-2882. doi:10.1109/tmi.2019.2916326Surti, S., & Karp, J. S. (2008). Design considerations for a limited angle, dedicated breast, TOF PET scanner. Physics in Medicine and Biology, 53(11), 2911-2921. doi:10.1088/0031-9155/53/11/010Surti, S., & Karp, J. S. (2016). Advances in time-of-flight PET. Physica Medica, 32(1), 12-22. doi:10.1016/j.ejmp.2015.12.007Grant, A. M., Deller, T. W., Khalighi, M. M., Maramraju, S. H., Delso, G., & Levin, C. S. (2016). NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system. Medical Physics, 43(5), 2334-2343. doi:10.1118/1.4945416Van Sluis, J., de Jong, J., Schaar, J., Noordzij, W., van Snick, P., Dierckx, R., … Boellaard, R. (2019). Performance Characteristics of the Digital Biograph Vision PET/CT System. Journal of Nuclear Medicine, 60(7), 1031-1036. doi:10.2967/jnumed.118.215418Ito, M., Lee, M. S., & Lee, J. S. (2013). Continuous depth-of-interaction measurement in a single-layer pixelated crystal array using a single-ended readout. Physics in Medicine and Biology, 58(5), 1269-1282. doi:10.1088/0031-9155/58/5/1269Bugalho, R., Di Francesco, A., Ferramacho, L., Leong, C., Niknejad, T., Oliveira, L., … Varela, J. (2018). Experimental results with TOFPET2 ASIC for time-of-flight applications. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 195-198. doi:10.1016/j.nima.2017.11.034Gundacker, S., Auffray, E., Frisch, B., Jarron, P., Knapitsch, A., Meyer, T., … Lecoq, P. (2013). Time of flight positron emission tomography towards 100ps resolution with L(Y)SO: an experimental and theoretical analysis. Journal of Instrumentation, 8(07), P07014-P07014. doi:10.1088/1748-0221/8/07/p07014A Code System for Monte Carlo Simulation of Electron and Photon Transporthttp://www.oecd-nea.org/lists/penelope.htmlStrydhorst, J., & Buvat, I. (2016). Redesign of the GATE PET coincidence sorter. Physics in Medicine and Biology, 61(18), N522-N531. doi:10.1088/0031-9155/61/18/n522Baró, J., Sempau, J., Fernández-Varea, J. M., & Salvat, F. (1995). PENELOPE: An algorithm for Monte Carlo simulation of the penetration and energy loss of electrons and positrons in matter. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 100(1), 31-46. doi:10.1016/0168-583x(95)00349-5Sempau, J., Acosta, E., Baro, J., Fernández-Varea, J. M., & Salvat, F. (1997). An algorithm for Monte Carlo simulation of coupled electron-photon transport. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 132(3), 377-390. doi:10.1016/s0168-583x(97)00414-xSempau, J., Fernández-Varea, J. M., Acosta, E., & Salvat, F. (2003). Experimental benchmarks of the Monte Carlo code penelope. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 207(2), 107-123. doi:10.1016/s0168-583x(03)00453-1Reader, A. J., Ally, S., Bakatselos, F., Manavaki, R., Walledge, R. J., Jeavons, A. P., … Zweit, J. (2002). One-pass list-mode EM algorithm for high-resolution 3-D PET image reconstruction into large arrays. IEEE Transactions on Nuclear Science, 49(3), 693-699. doi:10.1109/tns.2002.1039550Spanoudaki, V. C., & Levin, C. S. (2010). Photo-Detectors for Time of Flight Positron Emission Tomography (ToF-PET). Sensors, 10(11), 10484-10505. doi:10.3390/s101110484Siddon, R. L. (1985). Fast calculation of the exact radiological path for a three-dimensional CT array. Medical Physics, 12(2), 252-255. doi:10.1118/1.595715Vandenberghe, S., Daube-Witherspoon, M. E., Lewitt, R. M., & Karp, J. S. (2006). Fast reconstruction of 3D time-of-flight PET data by axial rebinning and transverse mashing. Physics in Medicine and Biology, 51(6), 1603-1621. doi:10.1088/0031-9155/51/6/017Performance Measurements of Positron Emission Tomographshttps://www.nema.org/Standards/ComplimentaryDocuments/Contents%20and%20Scope%20NEMA%20NU%202%202012.pdfYu, W., & Zeng, L. (2014). A Novel Weighted Total Difference Based Image Reconstruction Algorithm for Few-View Computed Tomography. PLoS ONE, 9(10), e109345. doi:10.1371/journal.pone.0109345Tashima, H., Yamaya, T., Yoshida, E., Kinouchi, S., Watanabe, M., & Tanaka, E. (2012). A single-ring OpenPET enabling PET imaging during radiotherapy. Physics in Medicine and Biology, 57(14), 4705-4718. doi:10.1088/0031-9155/57/14/4705Yamaya, T., Inaniwa, T., Minohara, S., Yoshida, E., Inadama, N., Nishikido, F., … Murayama, H. (2008). A proposal of an open PET geometry. Physics in Medicine and Biology, 53(3), 757-773. doi:10.1088/0031-9155/53/3/015Miyake, K. K., Matsumoto, K., Inoue, M., Nakamoto, Y., Kanao, S., Oishi, T., … Togashi, K. (2014). Performance Evaluation of a New Dedicated Breast PET Scanner Using NEMA NU4-2008 Standards. Journal of Nuclear Medicine, 55(7), 1198-1203. doi:10.2967/jnumed.113.131565Yamamoto, S., Honda, M., Oohashi, T., Shimizu, K., & Senda, M. (2011). Development of a Brain PET System, PET-Hat: A Wearable PET System for Brain Research. IEEE Transactions on Nuclear Science, 58(3), 668-673. doi:10.1109/tns.2011.2105502Garibaldi, F., Capuani, S., Colilli, S., Cosentino, L., Cusanno, F., Leo, R. D., … Tamma, C. (2013). TOPEM: A PET-TOF endorectal probe, compatible with MRI for diagnosis and follow up of prostate cancer. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 702, 13-15. doi:10.1016/j.nima.2012.09.020González-Montoro, A., Sánchez, F., Martí, R., Hernández, L., Aguilar, A., Barberá, J., … González, A. J. (2018). Detector block performance based on a monolithic LYSO crystal using a novel signal multiplexing method. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 372-377. doi:10.1016/j.nima.2017.10.09

Insulin and diabetes control in Argentina

En la Argentina al igual que en todo el mundo hay una brecha importante entre los conocimientos científicos sobre la diabetes mellitus (DM) y su aplicación en la práctica clínica. El control inadecuado de la DM y los factores de riesgo cardiovascular asociados genera una elevada morbimortalidad y el consecuente aumento de su carga socioeconómica. El diagnóstico tardío, la “inercia prescriptiva”, especialmente de insulina, y la educación deficiente de integrantes del equipo de salud y personas con diabetes, son algunos de los factores responsables de dicha situación. La implementación de un programa de educación diabetológica que incluya la organización de gabinetes de insulinización, a nivel nacional, dirigido tanto a prestadores como a personas con DM y sus familiares, contribuiría a optimizar la prescripción oportuna de insulina y mejorar la calidad de vida de las personas con DM, a la vez que reduciría la carga socioeconómica de la enfermedad. Para optimizar los resultados de esta estrategia educativa, es necesaria la participación de todos los subsectores de la salud (público, de la seguridad social y privado), de los medios masivos de comunicación, de las escuelas de ciencias de la salud, y de la industria farmacéutica.As in the rest of the world, there is a significant gap between scientific knowledge regarding diabetes mellitus and the daily practice outcome, in Argentina. Inadequate diabetes control combined with associated cardiovascular risk factors are responsible for an elevated morbid-mortality incidence and the consequent raise in the socioeconomic burden. Some of the factors leading to this situation are the late diagnosis of the disease, the clinical “inertia” (reluctance to prescribe insulin) and the poor education given to the health care team as well as the persons with diabetes. The implementation of a national diabetologic education program targeting health care providers, the persons with diabetes and their families, could contribute to optimize the appropriate insulin prescription, and consequently improve their life quality, while reducing the disease socioeconomic burden. In order to optimize the education program’s strategy outcome, insulinization cabinets should be incorporated, the participation of all health systems (public health, social security and private health insurance companies), the media, health sciences, schools and the pharmaceutical industry are needed.Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Costa Gil, José E.. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Faingold, María C.. Unidad Asistencial Dr. César Milstein; ArgentinaFil: Litwak, León. Hospital Italiano de Buenos Aires; ArgentinaFil: Fuente, Graciela V.. Hospital Carlos Durand; Argentin

Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea

Legumes play an important role in ensuring food security, improving nutrition and enhancing ecosystem resilience. Chickpea is a globally important grain legume adapted to semi-arid regions under rain-fed conditions. A growing body of research shows that aldehyde dehydrogenases (ALDHs) represent a gene class with promising potential for plant adaptation improvement. Aldehyde dehydrogenases constitute a superfamily of proteins with important functions as ‘aldehyde scavengers’ by detoxifying aldehydes molecules, and thus play important roles in stress responses. We performed a comprehensive study of the ALDH superfamily in the chickpea genome and identified 27 unique ALDH loci. Most chickpea ALDHs originated from duplication events and the ALDH3 gene family was noticeably expanded. Based on the physical locations of genes and sequence similarities, our results suggest that segmental duplication is a major driving force in the expansion of the ALDH family. Supported by expression data, the findings of this study offer new potential target genes for improving stress tolerance in chickpea that will be useful for breeding programs

Four haplotype blocks linked to Ascochyta blight disease resistance in chickpea under Mediterranean conditions

Ascochyta blight, caused by the fungal pathogen Ascochyta blight, caused by the fungal pathogen Ascochyta rabiei, is a devastating biotic stress that poses a significant threat to chickpea cultivation worldwide. To combat this disease, breeding programs have focused on developing cultivars with resistance to Ascochyta blight. However, a comprehensive understanding of the underlying plant defense mechanism is still lacking. To identify genomic regions associated with resistance, a recombinant inbred line (RIL) population was created by crossing ILC3279 (kabuli, resistant) and WR315 (desi, susceptible), which was then phenotyped and sequenced using a tuneable genotyping-by-sequencing (tGBS) protocol to obtain single nucleotide polymorphisms (SNPs). We further validated the association of genomic regions with Ascochyta blight resistance in a second recombinant inbred line\population derived from the cross between JG62 (desi, susceptible) and ILC72 (kabuli, resistant). Our analysis identified four genomic regions associated with Ascochyta blight resistance in chromosomes 2 and 4, among which a region spanning from 3.52 to 8.20 Mb in chromosome 4 was the most robust candidate for resistance, being associated with resistance in both years and populations. A total of 30 genes from the identified regions were selected as robust candidates, and LOC101507066, which encodes a leucine-rich repeat receptor-like protein kinase, was the most robust candidate gene, as it plays critical roles in plant stress responses and immunity. Our findings have potential to accelerate marker-assisted genetic improvement and facilitate the development of integrated strategies for crop protection

Efficiency of the cerebroplacental ratio in Identifying high-risk late-term pregnancies

Background and Objectives: Over the last few years, great interest has arisen in the role of the cerebroplacental ratio (CPR) to identify low-risk pregnancies at higher risk of adverse pregnancy outcomes. This study aimed to assess the predictive capacity of the CPR for adverse perinatal outcomes in all uncomplicated singleton pregnancies attending an appointment at 40–42 weeks. Materials and Methods: This is a retrospective cohort study including all consecutive singleton pregnancies undergoing a routine prenatal care appointment after 40 weeks in three maternity units in Spain and the United Kingdom from January 2017 to December 2019. The primary outcome was adverse perinatal outcomes defined as stillbirth or neonatal death, cesarean section or instrumental delivery due to fetal distress during labor, umbilical arterial cord blood pH < 7.0, umbilical venous cord blood pH < 7.1, Apgar score at 5 min < 7, and admission to the neonatal unit. Logistic mixed models and ROC curve analyses were used to analyze the data. Results: A total of 3143 pregnancies were analyzed, including 537 (17.1%) with an adverse perinatal outcome. Maternal age (odds ratio (OR) 1.03, 95% confidence interval (CI) 1.01 to 1.04), body mass index (OR 1.04, 95% CI 1.03 to 1.06), racial origin (OR 2.80, 95% CI 1.90 to 4.12), parity (OR 0.36, 95% CI 0.29 to 0.45), and labor induction (OR 1.79, 95% CI 1.36 to 2.35) were significant predictors of adverse perinatal outcomes with an area under the ROC curve of 0.743 (95% CI 0.720 to 0.766). The addition of the CPR to the previous model did not improve performance. Additionally, the CPR alone achieved a detection rate of only 11.9% (95% CI 9.3 to 15) when using the 10th centile as the screen-positive cutoff. Conclusions: Our data on late-term unselected pregnancies suggest that the CPR is a poor predictor of adverse perinatal outcomes

GALEX UV Color Relations for Nearby Early-Type Galaxies

We use GALEX/optical photometry to construct color-color relationships for early-type galaxies sorted by morphological type. We have matched objects in the GALEX GR1 public release and the first IR1.1 internal release, with the RC3 early-type galaxies having a morphological type -5.5<T<-1.5 with mean error in T<1.5, and mean error on (B-V)T<0.05. After visual inspection of each match, we are left with 130 galaxies with a reliable GALEX pipeline photometry in the far-UV and near-UV bands. This sample is divided into Ellipticals (-5.5<T<-3.5) and Lenticulars (-3.5<T<-1.5). After correction for the Galactic extinction, the color-color diagrams FUV-NUV vs. (B-V)_{Tc} are plotted for the two subsamples. We find a tight anti-correlation between the FUV-NUV and (B-V)_{Tc} colors for Ellipticals, the UV color getting bluer when the (B-V)_{Tc} get redder. This relationship very likely is an extension of the color-metallicity relationship into the GALEX NUV band. We suspect that the main source of the correlation is metal line blanketing in the NUV band. The FUV-NUV vs B-V correlation has larger scatter for lenticular galaxies; we speculate this reflects the presence of low level star formation. If the latter objects (i.e. those that are blue both in FUV-NUV and B-V) are interpreted as harboring recent star formation activity, this would be the case for a few percent (~4%) of Ellipticals and ~15% of Lenticulars; this would make about 10% of early-type galaxies with residual star formation in our full sample of 130 early-type galaxies. We also plot FUV-NUV vs. the Mg_2 index and central velocity dispersion. We find a tight anti-correlation between FUV-NUV and the Mg_2 index(...).Comment: 25 pages, 5 figures, accepted for publication in ApJS (abstract abridged), typos corrected in section 2.