The influence of oxygen concentration during embryo culture on obstetric and neonatal outcomes: a secondary analysis of a randomized controlled trial.

STUDY DESIGN, SIZE, DURATION: A secondary analysis of a previous randomized controlled trial assessing clinical pregnancy outcomes was carried out. This analysis included 1125 consecutive oocyte donation cycles utilizing ICSI or IVF and Day 3 embryo transfers between November 2009 and April 2012. The whole cohort of donated oocytes from patients who agreed to participate in the study were randomly allocated (1:1 ratio) to a reduced O2 tension group (6% O2) or an air-exposed group (20% O2) based on a computergenerated randomization list. Fresh and vitrified oocytes were used for oocyte donation. Only those pregnancies with a live birth at or beyond 24 weeks of gestation were included. PARTICIPANTS/MATERIALS, SETTING, METHODS: Day 3 embryos were cultured in an atmosphere of 5.5% CO2, 6% O2, 88.5% N2 versus a dual gas system in air. MAIN RESULTS AND THE ROLE OF CHANCE: From the eligible 1125 cycles, 564 were allocated to the 6% O2 group and 561 cycles to the 20% O2 group. However, 50 and 62 cycles did not reach embryo transfer in the 6% and 20% O2 groups, respectively. No differences were found between 6% O2 and atmospheric O2 tension in the number of livebirths per embryo transfer (mean § SD, 0.5 § 0.7 versus 0.5 § 0.7), pregnancy complications or neonatal outcomes. Both groups (6% and atmospheric O2) had similar single and twin delivery rates (40.8% versus 38.1% and 10.7% versus 12.3%, respectively). Preterm delivery rates and very preterm delivery rates (10.80% versus 13.24% and 1.25% versus 2.94%, respectively), birthweight (3229 § 561 g versus 3154 § 731 g), low birthweight (2.92% versus 2.45%), birth height (50.18 § 2.41 cm versus 49.7 § 3.59 cm), head circumference (34.16 § 1.87 cm versus 33.09 § 1.85 cm) and 1 min Apgar scores (8.96 § 0.87 versus 8.89 § 0.96) were also similar between 6% and atmospheric O2 groups, respectively. LIMITATIONS, REASONS FOR CAUTION: The number of liveborns finally analyzed is still small and not all obstetric and neonatal variables could be evaluated. Furthermore, a small proportion of the obstetric and neonatal data was obtained through a questionnaire VC The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: [email protected] Human Reproduction, Vol.0, No.0, pp. 1-14, 2020 doi:10.1093/humrep/deaa152 One reason for the lack of effect of oxygen concentration on pregnancy outcome could be the absence of trophectoderm cells at cleavage stage, which may make Day 3 embryos less susceptible to hypoxic conditions. WIDER IMPLICATIONS OF THE FINDINGS: Nowadays many IVF laboratories use a more physiological oxygen concentration for embryo culture. However, the benefits of using low oxygen concentration on both laboratory and clinical outcomes during embryo culture are still under debate. Furthermore, long-term studies investigating the effect of using atmospheric O2 are also needed. Gathering these type of clinical data is indeed, quite relevant from the safety perspective. The present data show that, at least in egg donation cycles undergoing Day 3 embryo transfers, culturing embryos under atmospheric oxygen concentration seems not to affect perinatal outcome

Columnar spaces in Valencian Gothic Architecture. The cloister of the Carthusian Monastery of Porta Coeli

[EN] The Cartuja of Porta Coeli preserves a Gothic cloister which, despite its small size and apparent simplicity, stands out for its compositional beauty and sophisticated stonework. It is, moreover, a particularly singular work in the context of Valencian medieval architecture. The eremitic nature of the Carthusian order, far from any contact with the outside world, has kept this exquisite architectural example, where the tradition of stonework and structural masonry coexist, practically intact until the present day. This text shows the results of the graphic and documentary analysis carried out, restoring, by means of the survey, the compositional laws and the trace as a graphic design method. The article, therefore, presents an initial study of this architectural space, placing it in the context of Valencian stonemasonry, at the time of the great master stonemasons, and, furthermore, it aims to provide a well-founded approach to the discovery of its authorship.[ES] La Cartuja de Porta Coeli conserva un claustro gótico que, pese a sus reducidas dimensiones y aparente sencillez, destaca por su belleza compositiva y sofisticada manufactura de cantería. Es, además, una obra especialmente singular en el contexto de la arquitectura medieval valenciana. El carácter eremítico de la orden Cartujana alejada de todo contacto con el mundo exterior, ha mantenido prácticamente intacto hasta nuestros días este exquisito ejemplo arquitectónico donde conviven la tradición de la cantería con la albañilería estructural. El presente texto muestra los resultados del análisis gráfico y documental realizado, restituyendo por medio del levantamiento, las leyes compositivas y la traza como método gráfico de diseño. El artículo, pues, plantea un primer estudio sobre este espacio arquitectónico, situándolo en el contexto de la cantería valenciana, en el momento de los grandes maestros canteros, y, además, pretende realizar un acercamiento fundado al descubrimiento de su autoría.Navarro Camallonga, P.; Verdejo Gimeno, P.; Priego De Los Santos, JE.; López Patiño, MG. (2022). Espacios columnarios en la arquitectura gótica valenciana. El claustrillo de la Cartuja de Porta Coeli. EGA Expresión Gráfica Arquitectónica. 27(44):26-39. https://doi.org/10.4995/ega.2022.16721OJS2639274

Seguridad de la información en la prevención de perdida de datos: una revisión sistemática

Currently, there is a notable increase in data loss cases, which can result in great economic losses for organizations. Data loss is a frequent problem in different information systems and can occur due to various reasons, such as hardware failure, human error, malicious attack, and natural disaster, among others. This systematic review aims to identify the impact of Information Security Management on the prevention of data loss. To carry out this research, the PRISMA methodology was used and searches were carried out in 6 databases: Scopus, Scielo, Alicia, Google Scholar, Science Direct and Redalyc. A total of 59 documents were found, and applying the exclusion and inclusion criteria, 9 documents were chosen for analysis. Of the selected documents, it was found that the massive increase in information stored in database systems has led to an increase in security breach attempts by outsiders. This research argues that organizations must implement adequate information security management to protect their data and the privacy of their customers. It is concluded that a suitable Information Security Management helps to reduce and prevent data loss by identifying and correcting vulnerabilities, which has an improvement relationship in the protection of data stored by organizations.Actualmente, se refleja una crecida notable en los casos de pérdida de datos, lo que puede resultar en grandes pérdidas económicas para las organizaciones. La pérdida de datos es un problema frecuente en los diferentes sistemas de información y puede ocurrir debido a diversos motivos, como fallos en el hardware, errores humanos, ataques maliciosos y desastres naturales, entre otros. Esta revisión sistemática tiene como objeto identificar el impacto de la Gestión de la seguridad de la información en la prevención de la pérdida de datos. Para realizar esta investigación, se utilizó la metodología PRISMA y se realizaron búsquedas en 6 bases de datos: Scopus, Scielo, Alicia, Google Académico, Science Direct y Redalyc. Se encontraron un total de 59 documentos, y luego de aplicar los criterios de exclusión e inclusión, se escogieron 9 documentos para su análisis. De los documentos seleccionados, se encontró que el aumento masivo de información guardada en sistemas de bases de datos ha llevado a un incremento en los intentos de violación de seguridad por parte de personas externas. Esta investigación sostiene que las organizaciones deben implementar una adecuada gestión de la seguridad de la información para proteger sus datos y la privacidad de sus clientes. Se concluye que una buena Gestión de la Seguridad de la Información ayuda a disminuir y prevenir la pérdida de datos al identificar y corregir vulnerabilidades, lo que tiene una relación de mejora en la protección de los datos almacenados por las organizaciones

Curso en línea como recurso didáctico para la asignatura "Administración de Recursos Humanos" en la DAIS-UJAT

La importancia estratégica de la educación en la Sociedad es, hoy por hoy innegable, especialmente para las Instituciones de Educación Superior (IES). Cierto es que el crecimiento del conocimiento en la humanidad exige cada vez menos tiempo para adaptarse en aspectos relacionados con los procesos de enseñanza-aprendizaje. Por lo cual vincular la tecnología como medio para la instrucción y el aprendizaje colaborativo, son elementos que constituyen una mejor calidad para el proceso enseñanza-aprendizaje del estudiante. El propósito que se persigue con este trabajo es la elaboración de un curso en línea que apoye y de soporte al proceso formativo en la asignatura de Administración de Recursos Humanos como recurso didáctico para estudiantes de la Licenciatura en Informática Administrativa adscritos a la División Académica de Informática y Sistemas en la UJAT. Para su desarrollo se ha elegido el modelo sistémico PRADDIE, así como el uso de las técnicas de la entrevista y encuestas; y como instrumento de recopilación de información el cuestionario

Polypropylene and polyvinylidene fluoride transobturator slings for the treatment of female stress urinary incontinence : 1-Year outcomes from a multicentre randomized trial

Finançament de: Fundación Dexeus Salud de la Mujer; CardiolinkTo compare the effectiveness and safety of polypropylene (PP) and polyvinylidene fluoride (PVDF) transobturator tapes (TOT) for the treatment of female stress urinary incontinence (SUI). This is a multicentre randomized trial. Women with SUI or stress-predominant mixed urinary incontinence and scheduled for a TOT procedure were randomized to PP or PVDF slings. The primary outcome was 1-year cure or improvement rate using composite criteria. Complications were also compared. Relationships with outcomes were analyzed using multivariable logistic regressions models. From April 2016 to January 2018 285 participants were randomized. PP and PVDF slings showed similar high cure or improvement rate (91.0% vs. 95.6%, p = .138). Improvement in validated questionnaires was also similar. PVDF slings were associated with a lower rate of de novo urgency incontinence (adjusted odds ratio = 0.35; 95% confidence interval = 0.15-0.80). We found no statistical differences in complications rates, although a higher incidence of long-term pain events were observed in the PP group. The study is underpowered to find differences in specific complications owing to the low number of events. PP and PVDF TOTs are equally effective, although PVDF is associated with fewer cases of de novo urgency incontinence. Further studies are needed to give robust conclusions on safety profiles

Long or complicated mpox in patients with uncontrolled HIV infection

To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, the aim of this study was to assess the impact of HIV on the clinical course of mpox, in a large population of patients from Spain. Nationwide case-series study. Patients from 18 Spanish hospitals, with PCR-confirmed mpox from April 27, 2022 to June 30, 2023 were included in this study. The main outcome was the development of long or complicated (LC) mpox, defined as: (i) duration of the clinical course ≥ 28 days, or; (ii) disseminated disease, or: (iii) emergence of severe complications. One thousand eight hundred twenty-three individuals were included. Seven hundred eighty-six (43%) were people living with HIV (PLWH), of whom 11 (1%) had a CD4 cell count < 200 cells/mm3 and 33 (3%) <350 cells/mm3 . HIV viral load ≥ 1000 cp/mL was found in 27 (3%) PLWH, none of them were on effective ART. Fifteen (60%) PLWH with HIV-RNA ≥ 1000 cp/mL showed LC versus 182 (29%) PLWH with plasma HIV-RNA load < 1000 copies/mL and 192 (24%) individuals without HIV infection (p < 0.001). In multivariate analysis, adjusted by age, sex, CD4 cell counts and HIV viral load at the time of mpox, only plasma HIV-RNA ≥ 1000 cp/mL was associated with a greater risk of developing LC mpox [adjusted OR = 4.06 (95% confidence interval 1.57-10.51), p = 0.004]. PLWH with uncontrolled HIV infection, due to lack of ART, are at a greater risk of developing LC mpox. Efforts should be made to ensure HIV testing is carried out in patients with mpox and to start ART without delay in those tested positive

Ciencias de la Biología y Agronomía

Este volumen I contiene 17 capítulos arbitrados que se ocupan de estos asuntos en Tópicos Selectos de Ciencias de la Biología y Agronomía, elegidos de entre las contribuciones, reunimos algunos investigadores y estudiantes. Se presenta un Estudio Comparativo de los Recursos Hidrológico-Forestales de la Microcuenca de la Laguna de Epatlan, Pue. (1993 a 2014); la Situación Actual de la Mancha de Asfalto en Maíz (Zea mays L.) en los Municipios de Jiquipilas y Ocozocoautla, Chiapas, México; las poblaciones sobresalientes de maíz de la raza Zapalote Chico, en la Región Istmeña de Oaxaca; Se indica el índice de área foliar de cultivo de Chile Poblano mediante dos métodos en condiciones protegidas; Esquivel, Urzúa y Ramírez exploran el efecto de la biofertilización con Azospirillum en el crecimiento y producción de Jitomate; esbozan su artículo sobre la determinación del nivel de Heterosis en híbridos de Maíz para la Comarca Lagunera; una investigación sobre la estabilización de semilla de Solanum lycopersicum durante el almacenamiento y estimulación de la germinación; acotan sobre el CTAB como una nueva opción para la detección de Huanglongbing en cítricos, plantean su evaluación sobre el aluminio y cómo afecta la vida de florero de Heliconia psittacorum; indican sobre el impacto del H-564C, como un híbrido de maíz con alta calidad de proteina para el trópico húmedo de México; presetan su investigación sobre la producción de Piña Cayena Lisa y MD2 (Ananas comosus L.) en condiciones de Loma Bonita, en Oaxaca; acotan sobre el efecto de coberteras como control biológico por conservación contra áfidos en Nogal Pecanero; esbozan sobre la caracterización de cuatro genotipos de Frijol Negro en Martínez de la Torre, Veracruz, México; presentan una caracterización hidroecológica de la microcuenca de Arroyo Prieto, Yuriría, Gto., y alternativas para su restauración ambiental; presentan su investigación sobre el efecto del hongo Beauveria bassiana sobre solubilización de fosfatos y la disponibilidad de fósforo en el suelo; plantean su investigación sobre la Germinación y regeneración in vitro de Epidendrum falcatum LINDL; esbozan su artículo sobre genotipos de frijol negro y su tolerancia a sequía terminal en Veracruz, México

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

Investigación en Matemáticas, Economía, Ciencias Sociales y Agronomía

Cada trabajo del libro incluye conclusiones para los interesados en las temáticas aludidas y en ellos nos enteramos de aspectos como los siguientes: - El mayor incremento del precio de los insumos como el maíz, sorgo y en menor medida desperdicio de pan, en relación con el menor crecimiento del precio del ganado en pie, dará como consecuencia un desabasto de carne bovina. - El agua es un recurso primordial en las zonas áridas y semiáridas de México, en tanto que su aporte limita la producción de la agricultura. En este estudio se observó que el precio real del agua es muy bajo en relación a otras zonas agrícolas del mundo. - Hoy en día en el país se consumen alrededor de 718 mil barriles diarios de gasolinas, un aproximado de 113.7 millones de litros, una cantidad tan grande que nuestro país se ve en la necesidad de importar cerca del 39 % de las gasolinas que consumimos. - Los jaliscienses radicados en Estados Unidos tienen una mayor capacidad de financiamiento del bienestar en la entidad, que el propio gobierno de ese estado. - México continuará basando sus finanzas públicas y su política de desarrollo económico en la extracción de combustibles fósiles (petróleo). Este modelo acelerará el deterioro y agotamiento de los recursos naturales. -La importancia de la agricultura orgánica radica en que retoma los tres ámbitos de la sustentabilidad; el ámbito ambiental, el económico y el social. - Es fundamental motivar la organización de los productores de haba para que ellos puedan captar una mayor proporción de los altos márgenes de precios que los consumidores están dispuestos a pagar. - Las condiciones del clima afectan a la producción agraria. Debido al fenómeno de cambio climático, es necesario contar con herramientas informáticas que proporcionen información climatológica para poder tomar medidas preventivas a favor de una mayor cantidad y calidad de producción. La herramienta de software permite la consulta del clima por localidades evitando la necesidad de contar con una estación meteorológica

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies