Implementing recombineering, Ribo-seq and DYI imaging to study plant hormones.

Every aspect of a plant life cycle, from germination to senescence, is coordinated by a small group of plant hormones. These small molecules do not work in isolation but through a complex network of interactions. In order to uncover the intricate interactions between different plant hormones, we have implemented a variety of technological tools, among them recombineering, ribosome footprinting or Ribo-seq), and high-throughput imaging. A brief overview of these technologies and their application to study the interaction between ethylene and auxin will be presented.Conferencia financiada con una ayuda del fondo para conferenciantes del Departamento de Biología Molecular y Bioquímica Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy. NAFLD covers a spectrum that ranges from simple steatosis, nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis, to cirrhosis, which is a major risk factor for hepatocellular carcinoma. Lifestyle and eating habit changes during the last century have made NAFLD the most common liver disease linked to obesity, type 2 diabetes mellitus and dyslipidemia, with a global prevalence of 25%. NAFLD arises when the uptake of fatty acids (FA) and triglycerides (TG) from circulation and de novo lipogenesis saturate the rate of FA β-oxidation and very-low density lipoprotein (VLDL)-TG export. Deranged lipid metabolism is also associated with NAFLD progression from steatosis to NASH, and therefore, alterations in liver and serum lipidomic signatures are good indicators of the disease's development and progression. This review focuses on the importance of the classification of NAFLD patients into different subtypes, corresponding to the main alteration(s) in the major pathways that regulate FA homeostasis leading, in each case, to the initiation and progression of NASH. This concept also supports the targeted intervention as a key approach to maximize therapeutic efficacy and opens the door to the development of precise NASH treatments

How local political preferences influence public housing reform

José M. Alonso and Rhys Andrews explore the extent to which housing stock transfer in local authorities across England has been shaped by local political ideology. They explain that ideology plays an important role in making housing reform happen, but that local people can also be a source of resistance and of alternatives to such reform

Which constituencies receive the most asylum seekers? privatisation and the politics of refugee dispersal in England

José M. Alonso and Rhys Andrews analyse the dispersal of asylum seekers across English local authorities before and after the Conservative-led privatisation of the system. They find that asylum dispersals to Labour Party ‘core’ constituencies increased since 2011, which suggests that governing parties can use privatisation as a political discipline mechanism

Coordinating heterogeneous IoT devices by means of the centralized vision of the SDN controller

The IoT (Internet of Things) has become a reality during recent years. The desire of having everything connected to the Internet results in clearly identified benefits that will impact on socio economic development. However, the exponential growth in the number of IoT devices and their heterogeneity open new challenges that must be carefully studied. Coordination among devices to adapt them to their users' context usually requires high volumes of data to be exchanged with the cloud. In order to reduce unnecessary communications and network overhead, this paper proposes a novel network architecture based on the Software-Defined Networking paradigm that allows IoT devices coordinate and adapt them within the scope of a particular context.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

One-on-one situation decision-making according to equipment in youth basketball

The goal was to verify with which ball participants improved the attackers' decisions in one-on-one game situations during youth basketball. Participants were 88 9- to 11-year-old boys from eight teams. We organized a three-day tournament consisting of 12 games, in which four games were played with each ball among all the teams. The balls differed only in their weight (440 g, 485 g, 540 g). The videos filmed were observed by two observers trained. The dependent variables were number of decisions, appropriate decisions, inappropriate decisions and ratio of correct to incorrect decisions, in the one-on-one situation. Participants made more decisions, and more correct (but not incorrect) decisions, when using the 440 -g rather than the regulation and 540 -g ball. This view requires that youth coaches act as a facilitator of learning, designing practice context according the objective evidence.This research was supported by Fundación Séneca: Agencia Regional de Ciencia y Tecnología de la Región de Murcia: 15349/PHCS/1