24 research outputs found
Viral Hepatitis C in a leading Brazilian hospital: epidemiological factors and genotyping
β-Lactam antibiotics and vancomycin inhibit the growth of planktonic and biofilm Candida spp.: An additional benefit of antibiotic-lock therapy?
AbstractThe aim of this study was to evaluate the effects of cefepime, meropenem, piperacillin/tazobactam (TZP) and vancomycin on strains of Candida albicans and Candida tropicalis in planktonic and biofilm forms. Twenty azole-derivative-resistant strains of C. albicans (n=10) and C. tropicalis (n=10) were tested. The susceptibility of planktonic Candida spp. to the antibacterial agents was investigated by broth microdilution. The XTT reduction assay was performed to evaluate the viability of growing and mature biofilms following exposure to these drugs. Minimum inhibitory concentrations (MICs) ranged from 0.5mg/mL to 2mg/mL for cefepime, TZP and vancomycin and from 0.5mg/mL to 1mg/mL for meropenem and the drugs also caused statistically significant reductions in biofilm cellular activity both in growing and mature biofilm. Since all of the tested drugs are commonly used in patients with hospital-acquired infections and in those with catheter-related infections under antibiotic-lock therapy, it may be possible to obtain an additional benefit from antibiotic-lock therapy with these drugs, namely the control of Candida biofilm formation
Dimorphandra mollis: An alternative as a source of flavonoids with antioxidant action
Os frutos da espécie Dimorphandra mollis são ricos nos flavonóides rutina e quercetina, que são
compostos com alta atividade antioxidante, podendo assim ser utilizados na prevenção de enfermidades
causados por radicais livres. O objetivo deste estudo foi obter um extrato rico em flavonóides a partir dos
frutos de D. mollis. O extrato foi analisado utilizando os métodos de doseamento por espectrofotometria e
cromatografia líquida de alta eficiência. Foi identificada a presença de rutina e quercetina no extrato, que
apresentou um teor de flavonóides totais de 33,71 %. O extrato, ainda, apresentou ação antioxidante favorável
frete aos radicais DPPH e ABTS. Assim, foi possível concluir que os frutos de D. mollis são uma rica
fonte de flavonóides de ação antioxidante.Dimorphandra
mollis fruits are rich in flavonoids rutin and quercetin, which are compounds with high antioxidant
activity and can be used to prevent diseases caused by free radicals. The aim of this study was to obtain an extract
rich in flavonoids from fruits of D. mollis. The extract was analyzed using the methods of determination by
spectrophotometry and high performance liquid chromatography. The presence of rutin and quercetin was identified
in the extract, which showed a total flavonoids content of 33.71 %. The extract also showed antioxidant activity
as scanvanger of DPPH and ABTS radicals. It was possible to conclude that D. mollis fruits are a rich
source of flavonoids with antioxidant action.Colegio de Farmacéuticos de la Provincia de Buenos Aire