One-on-one situation decision-making according to equipment in youth basketball

The goal was to verify with which ball participants improved the attackers' decisions in one-on-one game situations during youth basketball. Participants were 88 9- to 11-year-old boys from eight teams. We organized a three-day tournament consisting of 12 games, in which four games were played with each ball among all the teams. The balls differed only in their weight (440 g, 485 g, 540 g). The videos filmed were observed by two observers trained. The dependent variables were number of decisions, appropriate decisions, inappropriate decisions and ratio of correct to incorrect decisions, in the one-on-one situation. Participants made more decisions, and more correct (but not incorrect) decisions, when using the 440 -g rather than the regulation and 540 -g ball. This view requires that youth coaches act as a facilitator of learning, designing practice context according the objective evidence.This research was supported by Fundación Séneca: Agencia Regional de Ciencia y Tecnología de la Región de Murcia: 15349/PHCS/1

Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

There is a growing number of biomolecules, including peptides, proteins, monoclonal antibodies and RNA, that could be potentially used for the treatment of central nervous system (CNS) diseases. However, the realization of their potential is being hampered by the extraordinary difculties these complex biomolecules have to reach the brain in therapeutically meaningful amounts. Nose-to-brain (N-to-B) delivery is now being investigated as a potential option for the direct transport of biomolecules from the nasal cavity to diferent brain areas. Here, we discuss how diferent technological approaches enhance this N-to-B transport, with emphasis on those that have shown a potential for clinical translation. We also analyse how the physicochemical properties of nanocarriers and their modifcation with cell-penetrating peptides (CPPs) and targeting ligands afect their efcacy as N-to-B carriers for biomoleculesS

Distances and shooting zones as a function of mass of basketball among 9- to 11- year-old male players

The goal of this study was to analyse with which ball the participants attempted a greater number of shots and achieved more successful shots from distances greater than four meters and from positions outside the free throw lane. The 54 participants included 9 to 11-year-old children from six basketball teams. Three situations were established in which the participants played four games with each of the following balls: a regulation ball (485g, 69-71cm); a ball of smaller mass (440g, 69-71cm); and a ball of greater mass (540g, 69-71cm). The procedures that followed included: defining the variables; instructing the observers and obtaining reliability; monitoring the properties of the ball and filming the games; and recording the data from the observation. Kruskal-Wallis H was applied to determine in which categories there were significant differences. Then, post-hoc comparisons were performed with Mann-Whitney’s U to determine with which balls these differences occurred. The results did not reflect any statistically significant differences for attempted and successful shots from any distance and shooting zone with any ball. Shots were attempted with greatest frequency from a distance of less than four meters and from inside the free throw lane with all three balls

Shape phase transitions in odd-A nuclei

We investigate shape phase transitions in odd nuclei within the Interacting Boson Fermion Model. Special attention is given to the case of the transition from the vibrational behaviour to the stable axial deformation. The odd particle is assumed to be moving in the three single particle orbitals j=l/2,3/2,5/2 with a boson-fermion Hamiltonian that leads to the occurrence of the SU^^(3) boson-fermion symmetry when the boson part approaches the SU{3) condition. Both energy spectra and electromagnetic transitions show characteristic patterns similar to those displayed by the even nuclei at the corresponding critical point. The role of the additional particle in characterizing the properties of the critical points in finite quantal systems is investigated by resorting to the formalism based on the intrinsic frame

Comprehensive analysis of interstellar iso-propyl cyanide up to 480 ghz

\textit{Iso}-propyl cyanide, also known as \textit{iso}-butyronitrile, is a branched alkyl molecule recently detected in the interstellar medium.\footnote{A. Belloche, R. T. Garrod, H. S. P. M\"{u}ller, K. M. Menten, \textit{Science}, \textbf{2014}, \textit{345}, 1584.} A combination of Stark-modulated microwave spectroscopy and frequency-modulated millimeter and submillimeter wave spectroscopy was used to analyze its rotational spectrum from 26 to 480 GHz. Spectral assignments and analysis include transitions from the ground state, eight excited vibrational states and $^{13}$C isotopologues. Results of this work should facilitate astronomers further observations of \textit{iso}-propyl cyanide in the interstellar medium

Preferred conformers of non-proteinogenic amino acids homoserine and homocysteine

Vaporization of solid homoserine and homocysteine by laser ablation in combination with Fourier transform microwave spectroscopy techniques made possible the detection of their most stable structures in a supersonic expansion. All detected conformers have been identified through their rotational and $^{14}$N quadrupole coupling constants. They show hydrogen bonds linking the amino and carboxylic group through N--H$\cdot\cdot\cdot$O=C (type I) or N$\cdot\cdot\cdot$H--O (type II) interactions. In some of them there are additional hydrogen bonds established between the amino group and the hydroxyl/thiol groups in the gamma position. Entropic effects related to the side chain have been found to be significant in determining the most populated conformations

Seven conformers of pipecolic acid identified in the gas phase

The multiconformational landscape of the non-proteinogenic cyclic amino acid pipecolic acid has been explored in the gas phase. Solid pipecolic acid (m.p. 280$^{\circ}$C) was vaporized by laser ablation (LA) and expanded in a supersonic jet where the rotational spectra of seven conformers were obtained by broadband microwave spectroscopy (CP-FTMW). All conformers were conclusively identified by comparison of the experimental spectroscopic constants with those predicted theoretically. The relative stability of the conformers rests on a delicate balance of the different intramolecular hydrogen bonds established between the carboxylic and the amino groups

Millimeter wave spectra of methyl cyanate, methoxyamine and n-methylhydroxylamine: laboratory studies and astronomical search in space

Recent discovery of methyl isocyanate (CH$_{3}$NCO) in Sgr B2(N) and Orion KL\footnote{D.~T.~Halfen, V.~V.~Ilyushin, L.~Ziurys, \textit{Astrophys. J. Lett.}, \textbf{2015}, \textit{812}, L5.}$^{,}$\footnote{J.~Cernicharo, Z.~Kisiel, B.~Tercero, L.~Kolesnikov\'{a}, I.~R.~Medvedev et. al., \textit{Astron. $\&$ Astrophys.}, \textbf{2016}, \textit{587}, L4.} makes methyl cyanate (CH$_{3}$OCN) a potential molecule in the interstellar medium. Methoxyamine (CH$_{3}$ONH$_{2}$) and its isomeric form N-methylhydroxylamine (CH$_{3}$NHOH) may be considered as a potential interstellar amines.\footnote{R. T. Garrod, S. L. Widicus Weaver, E. Herbst, \textit{Astrophys. J.}, \textbf{2008}, \textit{682}, 283.} Pure rotational transitions belonging to the ground state and several excited vibrational states were measured and analyzed up to 400 GHz. Rotational transitions revealed $A$-$E$ splitting due to the methyl internal rotation and were globally analyzed in order to provide a precise set of the spectroscopic constants. Results of this work were used to search for the spectral features of methyl cyanate in Orion KL, Sgr B2(N), B1-b and TMC-1 molecular clouds.\footnote{L.~Kolesnikov\'{a}, J.~L.~Alonso, C. Berm\'{u}dez, E.~R.~Alonso, J.~Cernicharo et. al., \textit{Astron. $\&$ Astrophys.}, \textbf{2016}, accepted.

Some Lessons for the Future from the Global Malaria Eradication Programme (1955–1969)

Jose Najera and colleagues identify lessons from the Global Malaria Eradication Programme (1955–1969) relevant to current elimination and eradication efforts

Business computing - A shared curriculum proposal for the spanish-portuguese border under the auspices of the new european higher education area

The Bologna Declaration is leading to a change of paradigm in the context of higher education in many countries of the European Community; it has a significant impact at the level of curriculum and learning models. Therefore, any reflection and decision work on the processes of teaching/learning imposes the curricular reformulation of higher courses in an innovating way, supported by new references and assumptions. In the context of a project financed by European Community program Interreg III A, we have created a workgroup to o propose the reformulation of several courses that belong to Business Computing, from ESTiG-Portugal and from ESPZ-Spain, in an attempt to create harmony between both study plans, considering the socio-economic specific context of the border region between Braganca (Portugal) and Zamora (Spain). This article intends to describe a case-study related to the work done to achieve a curriculum for Business Computing; it describes the changes due to the recent recommendations of Bologna and governmental reflections of Portugal and Spain.This study was partly financed by the European Union with INTERREG III A funds