Quercus de M. Colmeiro (1816 - 1901) y J. Gay (1786 - 1864) en el Herbario del Real Colegio de Alfonso XII (San Lorenzo del Escorial, Madrid)

CARRASCO, MA., C. J. MARTÍN-BLANCO, A. GARCÍA & D. PEREA. 1998. Quercus de M. Colnieiro (1816-1901) y J. Gay (1786-1864) en el Herbario del Real Colegio Alfonso XII (San Lorenzo del Escorial, Madrid). Bot. Complutensis, 22: 153-171. En el Real Colegio Alfonso XII de San Lorenzo de El Escorial (Madrid), se han localinido una serie de paquetes de plantas que presentan interés histórico. Uno de ellos incluye pliegos de Quercus de las colecciones de M. Colmeiro y J. Cay, que damos a conocer en este trabajo. Entre ellos han aparecido los tipos nomenclaturales de Quercus avellanuefortnis Colmeiro & Boutelou, Quercus bellota var. grandifolia Colmeiro & Boutelou y Quercus bellota var. parvijó ha Colmeiro & Boutelou.CARRASCO, NI. A., C. J. MARTIN-BLANCO, A. GARCÍA & D. PEREA, 1998. The Quercus of M. Colmeiro(1816-1901) andi. Gay (1786-1864) in rhe Herbarium of the Real Colegio Alfonso XII (San Lorenzo del Escorial, Madrid). BoL Complutensis, 22: 153-171. Several sets of planís, with historic interest have been spotíed in the Real Colegio Alfonso XII, of San Lorenzo del Escorial, Madrid. la Ihis paper we present the study of one of those sets, belonging to the Colmeir&s and Gay's herbaria. Sorne of them are Typus materials (Quercus avellanaeformis Colmeiro & Boutelou, Quercus bellota var. grandifolia Colmeiro & Houtelou and Quercus bellota var. parvifolia Colmeiro & Boutelou)

Changes produced by the application of biostimulants on almond rootstocks properties during the nursery process

[EN] During the last ten years we have assisted to the consolidation of the almond crop that has remarkably increased its cultivation area causing a high demand for both plants and products related to growth stimulation. Accordingly, in the present work we aim to study the changes produced by the contribution of two biostimulants (humic and fulvic acids or aminoacids) on the properties of almond tree rootstocks. This kind of studies are of interest to the nursery cultivation industry where rapid growth of trees and good adaptation to their cultivation environment are required. Plants' radicular and vegetative systems responded differently according to the rootstock selection. The fastest and vigorous vegetative development was observed in GN rootstock whereas GF 677 showed the greatest number of main roots and RP-R of secondary roots. Differences on antioxidant activity and phenol content have also been found between rootstocks. All the tested samples were found to have a high antioxidant power and a high phenol content but GN stood out in this regard over the other rootstocks under study. The efficiency of the biostimulants applied has been verified. Both biostimulants promoted the development of the aerial part of the trees but biostimulant 2 did it to a greater extent. Biostimulant 1 was able to duplicate the number of main roots in RP-R and during the first year of study, biostimulant 2 originated an increase of the weight of the root system by 26.44% for RP-R, 16.93% for GF 677 and 48.00% for GN. In view of these results, synthetic chemical fertilizers can be at least partially replaced by biostimulants.Mondragón-Valero, A.; Malheiro, R.; Salazar Hernández, DM.; Pereira, JA.; López- Cortés, I. (2019). Changes produced by the application of biostimulants on almond rootstocks properties during the nursery process. Advances in Agriculture & Botanics (Online). 11(1):56-71. http://hdl.handle.net/10251/151095S567111

Effect Of Nb And Cu On The Crystallization Behavior Of Understoichiometric Nd–Fe–B Alloys

In this work, we present a complete study of the influence of Nb and Cu addition on the crystallization behavior of Nd-lean Nd-Fe-B melt-spun alloys. Alloys with compositions Nd10-x-yFe84B6NbxCuy (x = 1, y = 0 and x = 0.5, y = 0.5) were melt-spun at different wheel speeds (15-40 m s(-1)) to obtain samples in amorphous, highly disordered and nanocrystalline structures. The crystallization process, induced by different heat treatments, was studied by means of differential thermal analysis and x-ray powder thermodiffraction. Magnetic properties of as-made and heat-treated ribbons were measured by magnetometry. The as-made amorphous samples showed a crystallization to the 2: 14: 1 hard magnetic phase at T-1 similar to 350 degrees C. Doping with Nb results in an increase of T1, and addition of Cu lowers T1. This behavior is explained in terms of an inhibition of grain growth by Nb and a nucleation enhancement by Cu additions. During the crystallization process, a secondary phase (identified as a bcc-Fe-rich phase) is formed. The amount of such a phase increases with the annealing temperature. Coercivity increases upon annealing reaching maxima at 700-750 degrees C. This can be explained in terms of competition between the two phases formed: the 2: 14: 1 hard phase and the soft bcc-Fe-rich phase. The highest coercivity of the Nd-lean samples is observed when the microstructure is appropriate and both phases are exchange-coupled.This work has received funding from the DOE BES-DE-FG02-90ER45413 and the European Union MSCA grant agreement No 691235 (INAPEM). Technical and human support provided by SGIker (UPV/EHU, GV/EJ and ESF) is gratefully acknowledged

Physicochemical composition and antioxidant activity of several pomegranate (Punica granatum L.) cultivars grown in Spain

[EN] Nine pomegranate cultivars grown in Spain were selected, and their physicochemical (total soluble solids, pH, titratable acidity, maturity index, monomeric anthocyanin pigment, flavonoids, hydrolyzable tannins, and vitamin C) and antioxidant properties and polyphenolic composition of the juices were compared. A total of 53 polyphenols were identified, showing cultivars different profiles. Of all nine cultivars, Katirbasi had the highest contents of flavonoids, hydrolyzable tannins and vitamin C, as well as gallic acid and ellagic acid contents, explaining its high total reducing capacity. Principal component analysis allowed Katirbasi to be differentiated clearly from the others. Other cultivars presented also interesting characteristics such as high monomeric anthocyanin pigment content (CG8 cultivar) and interesting antioxidant activity (Wonderful 2 and CG8 cultivars). CG8 was the cultivar with the highest value of cyanidin-3,5-di-O-glucoside. Thus, this study will assist pomegranate producers in choosing the most suitable cultivar according to its ultimate use.Authors are grateful to POCTEP-Programa de Cooperacao Transfronteirica Espanha-Portugal for financial support through the Project "RED/AGROTEC - Experimentation network and transfer for development of agricultural and agro industrial sectors between Spain and Portugal" and CIMO through the Project PEst-OE/AGR/UI0690/2014 and the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013).Fernandes, L.; Pereira, JA.; López- Cortés, I.; Salazar Hernández, DM.; González-Álvarez, J.; Ramalhosa, E. (2017). Physicochemical composition and antioxidant activity of several pomegranate (Punica granatum L.) cultivars grown in Spain. 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InTech, CroatiaDepartment of Agriculture and Food, Western Australia, Growing pomegranates in Western Australia. http://www.agric.wa.gov.au . Accessed 29th Oct 2013Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AA (2000) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing‎. J Agric Food Chem 48:4581–4589Hernández F, Melgarejo P, Tomás-Barberán FA, Artés F (1999) Evolution of juice anthocyanins during ripening of new selected pomegranate (Punica granatum) clones. Eur Food Res Technol 210:39–42Jurenka J (2008) Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev 13:128–144Legua P, Melgarejo P, Martínez M, Hernández F (2009) Evolution of anthocyanin content of four pomegranate cultivars (Punica granatum L.) during fruit development. In: Melgarejo P, Martínez-Nicolás JJ, Martínez-Tomé J (eds) Production, processing and marketing of pomegranate in the Mediterranean region: Advances in research and technology, Options Méditerranéennes: Série A. Séminaires Méditerranéens, n. 42: CIHEAM, MadridMelgarejo P, Salazar DM, Artés F (2000) Organic acids and sugars composition of harvested pomegranate fruits. Eur Food Res Technol 211:185–190Nuncio-Jáuregui N, Nowicka P, Munera-Picazo S, Hernández F, Carbonell-Barrachina AA, Wojdyło A (2015) Identification and quantification of major derivatives of ellagic acid and antioxidant properties of thinning and ripe Spanish pomegranates. J Funct Foods 12:354–364Viuda-Martos M, Ruiz-Navajas Y, Fernández-López J, Sendra E, Sayas-Barberá E, Pérez-Álvarez JA (2011) Antioxidant properties of pomegranate (Punica granatum L.) bagasses obtained as co-product in the juice extraction. 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Food Chem 111:703–706Gadže J, Voća S, Čmelik Z, Mustać I, Ercisli S, Radunić M (2012) Physico-chemical characteristics of main pomegranate (Punica granatum L.) cultivars grown in Dalmatia region of Croatia. J Appl Bot Food Qual 85:202–206Radunić M, Špika MJ, Ban SG, Gadže J, Lean DM (2012) Chemical composition of pomegranate (Punica granatum L.) cultivars grown in Croatia. In: Melgarejo P, Valero D (eds) II International Symposium on the Pomegranate, Options Méditerranéennes—Series A: Mediterranean Seminars, CIHEAM, ValenciaLegua P, Melgarejo P, Abdelmajid H, Martínez JJ, Martínez R, Ilham H, Hafida H, Hernández F (2012) Total phenols and antioxidant capacity in 10 Moroccan pomegranate varieties‎. J Food Sci 71:115–120Ferrara G, Giancaspro A, Mazzeo A, Giove SL, Matarrese MAS, Pacucci C, Punzi R, Trani A, Gambacorta G, Blanco A, Gadaleta A (2014) Characterization of pomegranate (Punica granatum L.) genotypes collected in Puglia region Southeastern Italy. 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Junta de Gobierno establecida en la Ciudad de La Laguna : Con esta fecha ha dirigido esta Junta á la auxiliar de Gobierno ... el oficio siguiente: Esta Junta de Gobierno ha recibido con inesplicable [sic] júbilo las comunicaciones ... del éxito glorioso de la lucha emprendida por la nacion contra el hombre infame ..

Se trata del manifiesto de la Junta de Gobierno establecida en La Laguna, anunciando la suspensión de sus funcionesTexto firmado al final por El Conde de Valle-Salazar, José Trujillo y Domingo DarmaninTexto fechado en La Laguna 17 de agosto de 1843Última p. en bl

Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on Stavudine-Based Therapy

BACKGROUND: Low expression thymidylate synthase (TS) polymorphism has been associated with increased stavudine triphosphate intracellular (d4T-TP) levels and the lipodystrophy syndrome. The use of d4T has been associated with acute pancreatitis and peripheral neuropathy. However, no relationship has ever been proved between TS polymorphisms and pancreatitis and/or peripheral neuropathy. METHODS: We performed a case-control study to assess the relationship of TS and methylene-tetrahydrofolate reductase (MTHFR) gene polymorphisms with acute pancreatitis and/or peripheral neuropathy in patients exposed to d4T. Student's t test, Pearson's correlations, one-way ANOVA with Bonferroni correction and stepwise logistic regression analyses were done. RESULTS: Forty-three cases and 129 controls were studied. Eight patients (18.6%) had acute pancreatitis, and 35 (81.4%) had peripheral neuropathy. Prior AIDS was more frequent in cases than in controls (OR = 2.36; 95%CI 1.10-5.07, P = 0.0247). L7ow expression TS and MTHFR genotype associated with increased activity were more frequent in patients with acute pancreatitis and/or peripheral neuropathy than in controls (72.1% vs. 46.5%, OR = 2.97; 95%CI: 1.33-6.90, P = 0.0062, and 79.1% vs. 56.6%, OR = 2.90, 95%CI: 1.23-7.41, P = 0.0142, respectively). Independent positive or negative predictors for the development of d4T-associated pancreatitis and/or peripheral neuropathy were: combined TS and MTHFR genotypes (reference: A+A; P = 0.002; ORA+B = 0.34 [95%CI: 0.08 to 1.44], ORB+A = 3.38 [95%CI: 1.33 to 8.57], ORB+B = 1.13 [95%CI: 0.34 to 3.71]), nadir CD4 cell count >200 cells/mm(3) (OR = 0.38; 95%CI: 0.17-0.86, P = 0.021), and HALS (OR = 0.39 95%CI: 0.18-0.85, P = 0.018). CONCLUSIONS: Low expression TS plus a MTHFR genotype associated with increased activity is associated with the development of peripheral neuropathy in d4T-exposed patients

Physicochemical changes and antioxidant activity of juice, skin, pellicle and seed of pomegranate (cv. Mollar de Elchje) at different stages of ripening

In the present work, we investigate how the degree of ripeness (low, low-medium, medium and medium-high) aff ects the physical and compositional changes, as well as antioxidant properties of pomegranate fruit (cv. Mollar de Elche). The skin, pellicle, seed and juice were analysed. The fruit mass increased and the fruit skin became reddish (higher a* and lower h*) as the fruit ripening progressed. The lowest concentrations of fl avonoids and hydrolysable tannins were recorded in skin and pellicles at medium-high maturity stage, which explains the decrease in the total phenols and reducing power during ripening of pomegranate. On the contrary, the highest concentration of fl avonoids (165 mg of quercetin equivalents per 100 mL of juice) was determined in the juice at the most advanced ripening stage, concomitant with the highest total phenols (1695 mg of gallic acid equivalents per 100 mL of juice). Higher DPPH scavenging activity and an increase in the reducing power of juice were also observed during ripening. The trend of the above-mentioned properties allowed describing the fruit development and maturity.Fernandes, L.; Pereira, JA.; López Cortés, I.; Salazar Hernández, DM.; Ramalhosa, E. (2015). Physicochemical changes and antioxidant activity of juice, skin, pellicle and seed of pomegranate (cv. Mollar de Elchje) at different stages of ripening. Food Technology and Biotechnology. 53(4):397-406. doi:10.17113/ftb.53.04.15.3884S39740653

Llisses, orades i alguna anguila. L'ictiofauna mesolítica de les Coves de Santa Maira (Castell de Castells, La Marina Alta, Alacant)

There are several marine remains throughout the Coves de Santa Maira archaeological sequence which are indicative of relationships with the coastal lowlands. We studied the Mesolithic remains of fish and molluscs species found so far. It is a small sample, but interesting because it has allowed us to analyze the areas of obtaining these marine resources and suggest any reflection on their significance within the techno-economic transformation processes of the later prehistoric foragers

Towards a survival risk prediction model for metastatic NSCLC patients on durvalumab using whole-lung CT radiomics

BackgroundExisting criteria for predicting patient survival from immunotherapy are primarily centered on the PD-L1 status of patients. We tested the hypothesis that noninvasively captured baseline whole-lung radiomics features from CT images, baseline clinical parameters, combined with advanced machine learning approaches, can help to build models of patient survival that compare favorably with PD-L1 status for predicting ‘less-than-median-survival risk’ in the metastatic NSCLC setting for patients on durvalumab. With a total of 1062 patients, inclusive of model training and validation, this is the largest such study yet.MethodsTo ensure a sufficient sample size, we combined data from treatment arms of three metastatic NSCLC studies. About 80% of this data was used for model training, and the remainder was held-out for validation. We first trained two independent models; Model-C trained to predict survival using clinical data; and Model-R trained to predict survival using whole-lung radiomics features. Finally, we created Model-C+R which leveraged both clinical and radiomics features.ResultsThe classification accuracy (for median survival) of Model-C, Model-R, and Model-C+R was 63%, 55%, and 68% respectively. Sensitivity analysis of survival prediction across different training and validation cohorts showed concordance indices ([95 percentile]) of 0.64 ([0.63, 0.65]), 0.60 ([0.59, 0.60]), and 0.66 ([0.65,0.67]), respectively. We additionally evaluated generalization of these models on a comparable cohort of 144 patients from an independent study, demonstrating classification accuracies of 65%, 62%, and 72% respectively.ConclusionMachine Learning models combining baseline whole-lung CT radiomic and clinical features may be a useful tool for patient selection in immunotherapy. Further validation through prospective studies is needed

Personal body ornamentation on the Southern Iberian Meseta: An archaeomineralogical study

Beads and pendants from the Castillejo del Bonete (Terrinches, Ciudad Real) and Cerro Ortega (Villanueva de la Fuente, Ciudad Real) burials were analysed using XRD, micro-Raman and XRF in order to contribute to the current distribution map of green bead body ornament pieces on the Iberian Peninsula which, so far, remain undetailed for many regions. XRD, micro-Raman and XRF analyses showed that most of the beads from Castillejo del Bonete (Late 3rd millennium cal. BC) were made from variscite or green phyllosilicates, while Cerro Ortega's (Late 4th millenniumcal. BC) beads were made out of fossil wood or Clinochlore. Significantly enough,while XRD pointed to variscite as the main crystallo-graphic phase, the elemental composition did not match any elemental compositions of known and characterised sources, thus suggesting an unknown south-eastern source or an extra-peninsular origin of these ornamental pieces