Base de dados geodesicos para o Estado do Parana

Orientadores: Silvio Rogerio Correia de Freitas, Camil GemaelDissertação (mestrado) - Universidade Federal do ParanáResumo: O presente trabalho visa apresentar a concepção e as fases do projeto de uma base de dados geodésicos para o Estado do Paraná, dentro de um "Geographical Information System" (GIS). Como pressupostos, serão envolvidos todos os dados e informações complementares dos levantamentos de coordenadas geodésicas horizontais e verticais, assim como das grandezas gravimétricas. A estrutura da base tem uma arquitetura que permite a qualificação dos dados, usando modelos digitais de terreno (MDT) e modelos do Geopotencial (MGP), a seletividade por níveis de acurácia e tipos de usuários.Abstract: This work aims to present the conception and steps of a project of the Geodetic Data Base for the Paraná State, inside of a Geographical Information System (GIS). All data and complementary information of horizontal and vertical geodectic coordinates as well as gravimetric data, will be involved. The structure of base has an architecture allowing data qualification, by means the use of models like DTM and of the geopotencial, the selectivity by different accuracy levels and class o f users

KNOWLEDGE OF TOXOPLASMOSIS AMONG DOCTORS AND NURSES WHO PROVIDE PRENATAL CARE

Objetivos: descrever o conhecimento de médicos e enfermeiros pré-natalistas sobre a toxoplasmose.Método: estudo transversal, analítico, realizado entre outubro de 2018 e fevereiro de 2019, com 89 profissionais de 43 Unidades Básicas de Saúde de Aracaju, Sergipe, Brasil, por meio de questionário autoaplicado. Foram calculadas as frequências absolutas, relativas e os odds ratios. Utilizaram-se os testes Exato de Fischer e Qui-quadrado para análise dos dados.Resultados: os médicos e enfermeiros atuantes no pré-natal apresentaram pouco conhecimento sobre toxoplasmose relacionado às formas infectantes (p=1,000), vias de transmissão (p=1,000), grupo vulnerável (p=0,290), período de transmissão (p=1,000), maior risco para sequelas no recémnascido (p=0,828), quando realizar exames (p=0,015), indicação e interpretação do teste de avidez (p=0,355).Conclusão: este estudo identificou lacunas de conhecimento e poderá contribuir para planejamento de educação continuada para profissionais pré-natalistas, a fim de prevenir a toxoplasmose congênita.Objetivos: Describir el conocimiento de médicos y enfermeros de prenatal sobre la toxoplasmosis. Método: Estudio transversal, analítico, realizado entre octubre de 2018 y febrero de 2019, con 89 profesionales de 43 Unidades Básicas de Salud de Aracaju, Sergipe, Brasil, mediante cuestionario autocompletado. Se calcularon las frecuencias absolutas, relativas, y los odds ratios. Fueron utilizados para análisis de los datos los tests Exacto de Fischer y Chi-cuadrado. Resultados: Los médicos y enfermeros actuantes en el prenatal demostraron poco conocimiento sobre toxoplasmosisrespecto a sus vías de infección (p=1,000), modos de transmisión (p=1,000), grupo vulnerable (p=0,290), período de contagiosidad (p=1,000), riesgo mayor de secuelas en el recién nacido (p=0,828), momento de realización de análisis (p=0,015), indicación e interpretación del test de avidez (p=0,355). Conclusión: El estudio identificó brechas de conocimiento, y contribuirá a planificar una educación continua para profesionales de prenatal, a efectos de prevenir la toxoplasmosis congénita.Objectives: To describe the knowledge of doctors and nurses who provide prenatal care about toxoplasmosis.Method: Cross-sectional analytical study, conducted between October 2018 and February 2019, with 89 professionals from 43 Basic Health Units in Aracaju, State of Sergipe, in Brazil, through a self-administered questionnaire. Absolute and relative frequencies and odds ratios were calculated. Fischer Exact test and Chi-square test were used for data analysis.Results: Doctors and nurses who provide prenatal care have shown little knowledge about toxoplasmosis related to infectious forms (p = 1,000), transmission routes (p = 1,000), vulnerable group (p = 0,290), transmission period (p = 1,000), greater risk for complications in newborns (p = 0.828), when tests should be performed (p = 0.015), indication for performing and interpretation of the avidity test (p = 0.355).Conclusion: The present study identified knowledge gaps and may contribute to planning continuing education for prenatal care professionals, in order to prevent congenital toxoplasmosis

Repurposing agricultural waste as low-cost cultured meat scaffolds

Growing meat in vitro using tissue engineering and bioproduction techniques (cellular agriculture) has become an increasingly promising solution to the global food security challenge. Our lab has established methods to cultivate bovine muscle tissue on decellularized plants, representing a viable low-cost, sustainable method to grow meat on edible scaffolds. Most work in this area has focused on the use of edible plant materials (i.e., spinach leaves, apple, broccoli) with inherent economic value. Harvest waste such as corn husk or jackfruit represent abundant sources of cellulose for scaffold production and may be a viable alternative. The present study aims to investigate production of cultured meat through tissue engineering and bioproduction on decellularized, edible samples of corn husk and jackfruit rind. Corn husks and jackfruit rinds were exposed to immersion decellularization. DNA quantification and histological analysis demonstrated sufficient decellularization (0.17 ± 0.06 and 0.07 ± 0.00 ug DNA/g tissue for corn husk and jackfruit rinds, respectively). Following decellularization, corn husk scaffold stiffnesses decreased from 56.67±16.71 MPa to 12.95±2.43 MPa in fiber-aligned direction, while jackfruit decreased from 7.54 ±2.42 MPa to 2.47±1.47 MPa. Seeded scaffolds with bovine satellite cells (BSCs) (11.45±2.24 ug/ul lysate/Gram) and avian (QM7s) (12.90±1.99 ug/ul lysate/Gram) demonstrated increased protein yields on jackfruit scaffolds. QM7 cultured on corn husk scaffolds yielded increased protein but PBSCs seeded on corn husks did not yield protein content higher than controls (QM7 on corn husk: 16.28±3.55, PBSCs on corn husks: 9.57±1.56 ug/ul lysate/Gram, control: 6.35±1.43 ug/ul lysate/Gram). Additionally, cell transfer from scaffold to scaffold (bead-to-bead transfer) was observed on corn husk scaffolds in a dynamic environment. These results suggest that decellularized harvest waste scaffolds may aid in realization of cultured meat products that will contribute to a more robust and environmentally sustainable food supply

a space-time approach

Publisher Copyright: © 2024 | Epidemio is a publication of Associação Brasileira de Saúde Coletiva-ABRASCO.Objective: To identify the epidemiological, spatial, and temporal pattern of TB-HIV coinfection in Brazil during the period from 2001 to 2020. Methods: Ecological study using space-time analysis techniques. It included cases of TB-HIV coinfection registered in Brazil from 2001 to 2020. The temporal trend analysis was performed using segmented regression by Joinpoint regression. For spatial analysis, Moran indices were calculated and choropleth maps were produced using TerraView and QGIS software. Results: A stable temporal trend was observed in the incidence rates of TB-HIV coinfection in Brazil during the analyzed period. In addition, high-risk areas for coinfection located in states in the North, Southeast, South, and Midwest regions were identified. Conclusion: There was stability in the incidence of TB-HIV coinfection in Brazil over the last 20 years and heterogeneous geographic distribution of risk areas for the condition.publishersversionpublishe

Cartilage restoration of patellofemoral lesions: a systematic review

Purpose This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery. Methods This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed, EMBASE, and Cochrane Library databases were searched up to August 31, 2018, to identify clinical studies that assessed surgical outcomes of patellofemoral cartilage restoration surgery. The Methodological Index for Non-Randomized Studies (MINORS) was used to assess study quality. Results Forty-two studies were included comprising 1,311 knees (mean age of 33.7 years and 56% males) and 1,309 patellofemoral defects (891 patella, 254 trochlear, 95 bipolar, and 69 multiple defects, including the patella or trochlea) at a mean follow-up of 59.2 months. Restoration techniques included autologous chondrocyte implantation (56%), particulated juvenile allograft cartilage (12%), autologous matrix-induced chondrogenesis (9%), osteochondral autologous transplantation (9%), and osteochondral allograft transplantation (7%). Significant improvement in at least one score was present in almost all studies and these surpassed the minimal clinically important difference threshold. There was a weighted 19%, 35%, and 6% rate of reported complications, reoperations, and failures, respectively. Concomitant patellofemoral surgery (51% of patients) mostly did not lead to statistically different postoperative outcomes. Conclusion Numerous patellofemoral restoration techniques result in significant functional improvement with a low rate of failure. No definitive conclusions could be made to determine the best surgical technique since comparative studies on this topic are rare, and treatment choice should be made according to specific patient and defect characteristics

Applications of scalar attractor solutions to Cosmology

We develop a framework to study the phase space of a system consisting of a scalar field rolling down an arbitrary potential with varying slope and a background fluid, in a cosmological setting. We give analytical approximate solutions of the field evolution and discuss applications of its features to the issues of quintessence, moduli stabilisation and quintessential inflation.Comment: 9 pages, 7 figures. Accepted for publication in PR

Remoção cirúrgica de Tórus Mandibular Bilateral: relato de caso / Surgical removal of Bilateral Mandibular Torus: case report

O tórus é uma exostose óssea de progressão lenta e etiologia desconhecida. Clinicamente, apresenta-se em formato arredondado, superfície lisa, projeções de ossos duros e cobertos com mucosa normal. Na mandíbula, geralmente está presente na região lingual dos incisivos e pré-molares, podendo ser uni ou bilateral. Normalmente, são condições assintomáticas e não requerem tratamento. Em casos de maior extensão, o indivíduo recorre a procedimentos cirúrgicos para evitar ulcerações e traumas crônicos em mucosa.  O presente trabalho relata a remoção cirúrgica de tórus mandibular em uma paciente gênero feminino, queixando-se de abaulamento bilateral na região de pré-molares inferiores, com ulcerações recorrentes e evolução de 10 anos. O procedimento cirúrgico foi realizado em ambiente ambulatorial, em duas etapas. Foram confeccionadas incisões intrasulculares, descolamento mucoperiosteal para visualização do tórus mandibular, com posterior ostectomia e remoção do mesmo com o auxílio de instrumentais cirúrgicos. A paciente apresentou boa evolução, sem queixas no pós-operatório e rápida recuperação