Application of the Tool for Turbine Engine Closed-loop Transient Analysis (TTECTrA) for Dynamic Systems Analysis

Systems analysis involves steady-state simulations of combined components to evaluate the steady-state performance, weight, and cost of a system; dynamic considerations are not included until later in the design process. The Dynamic Systems Analysis task, under NASAs Fixed Wing project, is developing the capability for assessing dynamic issues at earlier stages during systems analysis. To provide this capability the Tool for Turbine Engine Closed-loop Transient Analysis (TTECTrA) has been developed to design a single flight condition controller (defined as altitude and Mach number) and, ultimately, provide an estimate of the closed-loop performance of the engine model. This tool has been integrated with the Commercial Modular Aero-Propulsion System Simulation 40,000 (CMAPSS 40k) engine model to demonstrate the additional information TTECTrA makes available for dynamic systems analysis. This dynamic data can be used to evaluate the trade-off between performance and safety, which could not be done with steady-state systems analysis data. TTECTrA has been designed to integrate with any turbine engine model that is compatible with the MATLAB Simulink (The MathWorks, Inc.) environment

X-box-binding protein 1 and innate immune responses of human cystic fibrosis alveolar macrophages

Rationale: Alveolar macrophages (AMs) play a key role in host defense to inhaled bacterial pathogens, in part by secreting inflammatory mediators. Cystic fibrosis (CF) airways exhibit a persistent, robust inflammatory response that may contribute to the pathophysiology of CF. Recent findings have linked endoplasmic reticulum stress responses mediated by inositol-requiring enzyme 1a-dependentmessengerRNAsplicing (activation) ofX-box-binding protein-1 (XBP-1s) to inflammation in peripheral macrophages. However, the role of XBP-1s in CF AMfunction is not known. Objectives: To evaluate inflammatory responses of AMs from chronically infected/inflamed human CF lungs and test whether XBP-1s is required for AM-mediated inflammation. Methods: Basal and LPS-induced inflammatory responses were evaluated in primary cultures of non-CF versus CF AMs. XBP-1s was measured and its function was evaluated in AMs using 8-formyl-7-hydroxy-4-methylcoumarin (4μ8C), an inhibitor of inositolrequiring enzyme 1a-dependent XBP-1s, and in THP-1 cells stably expressing XBP-1 shRNA, XBP-1s, or a dominant-negative XBP-1. Measurements and Main Results: CF AMs exhibited exaggerated basal and LPS-induced production of tumor necrosis factor-a and IL-6, and these responses were coupled to increased levels of XBP-1s. In non-CF and CF AMs, LPS-induced cytokine production was blunted by 4μ8C. A role for XBP-1s in AM inflammatory responses was further established by data from dTHP-1 cells indicating that expression of XBP-1 shRNA reduced XBP-1s levels and LPS-induced inflammatory responses; and LPS-induced inflammation was upregulated by expression of XBP-1s and inhibited by dominantnegative XBP-1. Conclusions: These findings suggest that AMs contribute to the robust inflammation of CF airways via an up-regulation of XBP-1smediated cytokine production

An assessment of early 20th Century Antarctic pressure reconstructions using historical observations

While gridded seasonal pressure reconstructions poleward of 60°S extending back to 1905 have been recently completed, their skill has not been assessed prior to 1958. To provide a more thorough evaluation of the skill and performance in the early 20th century, these reconstructions are compared to other gridded datasets, historical data from early Antarctic expeditions, ship records, and temporary bases. Overall, the comparison confirms that the reconstruction uncertainty of 2–4 hPa (evaluated after 1979) over the Southern Ocean is a valid estimate of the reconstruction error in the early 20th century. Over the interior and near the coast of Antarctica, direct comparisons with historical data are challenged by elevation‐based reductions to sea level pressure. In a few cases, a simple linear adjustment of the reconstruction to sea level matches the historical data well, but in other cases, the differences remain greater than 10 hPa. Despite these large errors, comparisons with continuous multi‐season observations demonstrate that aspects of the interannual variability are often still captured, suggesting that the reconstructions have skill representing variations on this timescale, even if it is difficult to determine how well they capture the mean pressure at these higher elevations. Additional comparisons with various 20th century reanalysis products demonstrate the value of assimilating the historical observations in these datasets, which acts to substantially reduce the reanalysis ensemble spread, and bring the reanalysis ensemble mean within the reconstruction and observational uncertainty

A circular polarimeter for the Cosmic Microwave Background

A primordial degree of circular polarization of the Cosmic Microwave Background is not observationally excluded. The hypothesis of primordial dichroism can be quantitatively falsified if the plasma is magnetized prior to photon decoupling since the initial V-mode polarization affects the evolution of the temperature fluctuations as well as the equations for the linear polarization. The observed values of the temperature and polarization angular power spectra are used to infer constraints on the amplitude and on the spectral slope of the primordial V-mode. Prior to photon decoupling magnetic fields play the role of polarimeters insofar as they unveil the circular dichroism by coupling the V-mode power spectrum to the remaining brightness perturbations. Conversely, for angular scales ranging between 4 deg and 10 deg the joined bounds on the magnitude of circular polarization and on the magnetic field intensity suggest that direct limits on the V-mode power spectrum in the range of 0.01 mK could directly rule out pre-decoupling magnetic fields in the range of 10-100 nG. The frequency dependence of the signal is located, for the present purposes, in the GHz range.Comment: 28 pages, 12 included figures

Reconstructing the Antarctic ice-sheet shape at the Last Glacial Maximum using ice-core data

The Antarctic ice sheet (AIS) is the Earth’s largest store of frozen water; understanding how it changed in the past allows us to improve projections of how it, and sea levels, may change. Here, we use previous AIS reconstructions, water isotope ratios from ice cores, and simulator predictions of the relationship between the ice-sheet shape and isotope ratios to create a model of the AIS at the Last Glacial Maximum. We develop a prior distribution that captures expert opinion about the AIS, generate a designed ensemble of potential shapes, run these through the climate model HadCM3, and train a Gaussian process emulator of the link between ice-sheet shape and isotope ratios. To make the analysis computationally tractable, we develop a preferential principal component method that allows us to reduce the dimension of the problem in a way that accounts for the differing importance we place in reconstructions, allowing us to create a basis that reflects prior uncertainty. We use Markov chain Monte Carlo to sample from the posterior distribution, finding shapes for which HadCM3 predicts isotope ratios closely matching observations from ice cores. The posterior distribution allows us to quantify the uncertainty in the reconstructed shape, a feature missing in other analyses

Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study

This work was supported by the British Heart Foundation PG/10/37/28347, RG/10/11/28457, NIHR Biomedical Research Centre funding, and the ElectroCardioMaths Programme of the Imperial BHF Centre of Research Excellence

Snow petrel stomach-oil deposits as a new biological archive of Antarctic sea ice

Where snow petrels forage is predominantly a function of sea ice. They spit stomach oil in defence, and accumulated deposits at nesting sites are providing new opportunities to reconstruct their diet, and, in turn, the sea-ice environment over past millennia

Observation of Parity Violation in the Omega-minus -> Lambda + K-minus Decay

The alpha decay parameter in the process Omega-minus -> Lambda + K-minus has been measured from a sample of 4.50 million unpolarized Omega-minus decays recorded by the HyperCP (E871) experiment at Fermilab and found to be [1.78 +/- 0.19(stat) +/- 0.16(syst)]{\times}10^{-2}. This is the first unambiguous evidence for a nonzero alpha decay parameter, and hence parity violation, in the Omega-minus -> Lambda + K-minus decay.Comment: 10 pages, 7 figure

Magnetic Field Effects on the Far-Infrared Absorption in Mn_12-acetate

We report the far-infrared spectra of the molecular nanomagnet Mn_12-acetate (Mn_12) as a function of temperature (5-300 K) and magnetic field (0-17 T). The large number of observed vibrational modes is related to the low symmetry of the molecule, and they are grouped together in clusters. Analysis of the mode character based on molecular dynamics simulations and model compound studies shows that all vibrations are complex; motion from a majority of atoms in the molecule contribute to most modes. Three features involving intramolecular vibrations of the Mn_12 molecule centered at 284, 306 and 409 cm-1 show changes with applied magnetic field. The structure near 284 cm$^{-1}$ displays the largest deviation with field and is mainly intensity related. A comparison between the temperature dependent absorption difference spectra, the gradual low-temperature cluster framework distortion as assessed by neutron diffraction data, and field dependent absorption difference spectra suggests that this mode may involve Mn motion in the crown.Comment: 5 pages, 4 figures, PRB accepte