A Scrabble Artificial Intelligence Game

Computer AI players have already surpassed human opponents in competitive Scrabble, however, defeating a Computer AI opponent is complex and demands efficient heuristics. The primary objective of this project is to build two intelligent AI players from scr atch for the Scrabble cross - board puzzle game having different move generation heuristics and endgame strategies to evaluate their performance based on various benchmarks like winning criteria, quality of moves, and time consumption. The first AI selected is the most popular Scrabble AI, Maven. It generates a three - ply look - ahead simulation to evaluate the most promising candidate move and uses four different heuristics for the fast move-generation. The second AI, Quackle, is the strongest alternative Scrabble AI to Maven. It generates its best candidate move by using a three-ply look-ahead simulation and win probability estimation. In this project, we primarily focus on the end - game heuristics because end-game sessions are complex, real-world situations where the move options are limited and require expert techniques and model strategies to maximize the reward. Moreover, the basic game heuristics used in the mid-game are not sufficient for an end-game. For this project, we created four variants of Maven AI. After conducting experiments, we observed that Maven Q - Sticking slow - end game AI performs better than other AI variants like Maven Q - Sticking AI, Maven slow - end game AI, No Q - Sticking AI and Quackle AI

Licorice (glycyrrhiza glabra) extracts-suitable pharmacological interventions for covid-19? a review

Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome (ARDS), which is the primary cause of mortality among the COVID-19 patients. In reference to these tasks, this article considers the properties of a medicinal plant named licorice (Glycyrrhiza glabra), whose phytochemicals have shown both antiviral and anti-inflammatory tendencies through previous studies. All the literature was selected through extensive search in various databases such as google scholar, Scopus, the Web of Science, and PubMed. In addition to the antiviral and anti-inflammatory properties, one of the licorice components has an autophagy-enhancing mechanism that studies have suggested to be necessary for COVID-19 treatment. Based on reviewing relevant professional and historical literature regarding the medicinal properties of licorice, it is suggested that it may be worthwhile to conduct in vitro and in vivo studies, including clinical trials with glycyrrhizic and glycyrrhetinic acids together with other flavonoids found in licorice, as there is the potentiality to provide natural interventions against COVID-19 symptoms. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Can optimum solar radiation exposure or supplemented vitamin D intake reduce the severity of COVID-19 symptoms?

The foremost mortality-causing symptom associated with COVID-19 is acute respiratory distress syndrome (ARDS). A significant correlation has been identified between the deficiency in vitamin D and the risk of developing ARDS. It has been suggested that if we can reduce or modify ARDS in COVID-19 patients, we may significantly reduce the severity of COVID-19 symptoms and associated mortality rates. The increased mortality of dark-skinned people, who have a reduced UV absorption capacity, may be consistent with diminished vitamin D status. The factors associated with COVID-19 mortality, such as old age, ethnicity, obesity, hypertension, cardiovascular diseases, and diabetes, are all found to be linked with vitamin D deficiency. Based on this review and as a precautionary measure, it is suggested that the adoption of appropriate and safe solar exposure and vitamin D enriched foods and supplements should be considered to reduce the possible severity of COVID-19 symptoms. Safe sun exposure is deemed beneficial globally, specifically in low and middle- income countries, as there is no cost involved. It is also noted that improved solar exposure and vitamin D levels can reduce the impact of other diseases as well, thus assisting in maintaining general human well-being. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

The influence of controlled fire on the mobilization of Potentially Toxic Elements (PTE) in a mined landscape : Implications for land management and environmental health

Controlled fires conducted in fire prone areas are an efficient and economic option to reduce the frequency and intensity of wild fires that result in damage to human property, infrastructure and ecosystems. However, in a similar way to wild fires, controlled fires affect many of the physical and bio-geochemical properties of the forest soil, and may remobilize Potentially Toxic Elements (PTE) from vegetation and soil organic matter. The objective of this study is to investigate the mobilization of PTEs in a mined landscape after a controlled fire and to describe their temporal variations in concentrations. Soil samples were collected two days before and two days after the controlled fire, at the end of each season, and after a major rainfall in September 2016, from a legacy mine site in Maldon, Central Victoria, Australia, and analysed for PTE concentrations. The results revealed PTE mobility after the controlled fire, and most of the PTEs (As, Cd, Cu, Mn, and Zn) evidenced an increase in concentration (1.2, 1.5, 1.1, 2.9, and 1.7 times respectively) and other PTEs (Hg, Cr and Pb) shown a decrease (1.4, 1.1 and 1.1 times respectively) immediately after the fire. The increase in PTE concentration immediately after the fire is postulated to be associated with the addition of PTE enriched ash to the soil and the reduction is due to the volatilization of elements during fire. The PTEs, which increased their concentrations immediately after the fire show a temporal decrease in concentration in the post-fire soil environment due to the removal of ash and surface soil by rainfall runoff, leaching and wind activity. However, Hg shows an increase in concentration after the major rainfall event. Although, median concentrations of As, Hg, Pb, Cu and Zn exceeded the Australian and Victorian top soil averages, only As and Hg are considered to be a risk to human and aquatic ecosystems health due to their elevated concentration and toxicity. Climate change and the resulting projection for increased forest fire frequency illustrates a growing concern given the expected concomitant increase in PTE mobilization. Preparing appropriate land and water management strategies, and addressing environmental health practice and policy, specifically at the legacy mining areas require a review. This study highlights the significant risk these sites pose.Doctor of Philosoph

Does climate play any role in covid-19 spreading? : an Australian perspective

Compared to other countries, the COVID-19 pandemic did not severely affect Australia as measured by total deaths until mid-2021. Though a substantial number of daily confirmed cases (up to 698) were reported during the second wave, most of them were from the southern state of Victoria. This study examined the possible correlations between climate variables and the number of daily confirmed COVID-19 cases in Victoria, Australia, from 25 January to 31 October 2020. Appropriate regression models and cross-correlation diagnostics were used to examine the effect of temperature, rainfall, solar exposure, and ultraviolet index (UVI) with the number of daily confirmed cases. Significant positive associations were identified for solar exposure and maximum and average UVI for confirmed cases one and 19 days later. Negative associations for these variables were found for confirmed cases five days later. Minimum temperature had a significant negative correlation one day later and a positive effect 21 days later. No significant correlation was found for maximum temperature and rainfall. The most significant relationships were found for confirmed cases 19 days after changes in the meteorological variables. A 1% increase in solar exposure, maximum UVI, and average UVI was associated with a 0.31% (95% CI: 0.13 to 0.51), 0.71% (95% CI: 0.43 to 0.98), and 0.63% (95%CI: 0.20 to 1.61) increase 19 days later in the number of confirmed cases, respectively. The implications of these results can be used in the public health management of any possible future events in Australia. It also highlights the significance of considering the climatic variables and seasonality in all kinds of epidemics and pandemics. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

Licorice (Glycyrrhiza glabra) Extracts-Suitable Pharmacological Interventions for COVID-19? A Review

Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome (ARDS), which is the primary cause of mortality among the COVID-19 patients. In reference to these tasks, this article considers the properties of a medicinal plant named licorice (Glycyrrhiza glabra), whose phytochemicals have shown both antiviral and anti-inflammatory tendencies through previous studies. All the literature was selected through extensive search in various databases such as google scholar, Scopus, the Web of Science, and PubMed. In addition to the antiviral and anti-inflammatory properties, one of the licorice components has an autophagy-enhancing mechanism that studies have suggested to be necessary for COVID-19 treatment. Based on reviewing relevant professional and historical literature regarding the medicinal properties of licorice, it is suggested that it may be worthwhile to conduct in vitro and in vivo studies, including clinical trials with glycyrrhizic and glycyrrhetinic acids together with other flavonoids found in licorice, as there is the potentiality to provide natural interventions against COVID-19 symptoms

A Dynamic Framework for Evaluating DTLS using Network Simulator (ns-3)

This thesis focuses on the development and implementation of a Datagram Transport Layer Security (DTLS) communication framework within the ns-3 network simulator, specifically targeting the LoRaWAN model network. The primary aim is to analyse the behaviour and performance of DTLS protocols across different network conditions within a LoRaWAN context. The key aspects of this work include the following. Utilization of ns-3: This thesis leverages ns-3’s capabilities as a powerful discrete event network simulator. This platform enables the emulation of diverse network environments, characterized by varying levels of latency, packet loss, and bandwidth constraints. Emulation of Network Challenges: The framework specifically addresses unique challenges posed by certain network configurations, such as duty cycle limitations. These constraints, which limit the time allocated for data transmission by each device, are crucial in understanding the real-world performance of DTLS protocols. Testing in Multi-client-server Scenarios: A significant feature of this framework is its ability to test DTLS performance in complex scenarios involving multiple clients and servers. This is vital for assessing the behaviour of a protocol under realistic network conditions. Realistic Environment Simulation: By simulating challenging network conditions, such as congestion, limited bandwidth, and resource constraints, the framework provides a realistic environment for thorough evaluation. This allows for a comprehensive analysis of DTLS in terms of security, performance, and scalability. Overall, this thesis contributes to a deeper understanding of DTLS protocols by providing a robust tool for their evaluation under various and challenging network conditions

Mucinous Cystic Neoplasm in Heterotopic Pancreas Presenting as Colonic Polyp

Context Pancreatic heterotopia in itself is rare in the colon and to the best of our knowledge a neoplasm arising in a heterotopic tissue in the colon has not been reported. We herein report a pancreatic cystic neoplasm arising from heterotopic pancreatic tissue in colon. Case report A 44-year-old lady presented with a history of lower abdominal colic, associated with mucoid loose stools 10-15 times/day. Fecal occult blood was positive on two occasions. On examination, a vague mass was palpable in the left upper quadrant of abdomen. Colonoscopy showed a polypoid growth at the splenic flexure of colon, which on biopsy was reported to be an inflammatory polyp. She underwent a laparoscopic converted to open left hemicolectomy. Post-operatively she developed a intra-abdominal collection which formed a controlled pancreatic fistula after percutaneous drainage. Histopathology revealed pancreatic heterotopia with pancreatic mucinous cystic neoplasm. Conclusion Despite advances in patient care, preoperative diagnosis of heterotopic pancreas is difficult.Image: Pedunculated polypoidal mass