The effects of environmental context on laboratory rat social recognition

The effects of environmental context on laboratory rat social recognitio

Total skin self-examination at home for people treated for cutaneous melanoma : development and pilot of a digital intervention

This work was funded by the RCUK Digital Economy award to the dot.rural Digital Economy Hub, University of Aberdeen; award reference: EP/G066051/1. The Experience Laboratory event was supported in part by a separate award from the University of Aberdeen Knowledge Exchange and Transfer Fund; award reference: GP057 UZZ0101.Peer reviewedPublisher PD

Climate-driven Shifts in Quantity and Seasonality of River Discharge over the past 1000 Years from the Hydrographic Apex of North America

Runoff generated from high elevations is the primary source of freshwater for western North America, yet this critical resource is managed on the basis of short instrumental records that capture an insufficient range of climatic conditions. Here we probe the effects of climate change over the past ~1000 years on river discharge in the upper Mackenzie River system based on paleoenvironmental information from the Peace-Athabasca Delta. The delta landscape responds to hydroclimatic changes with marked variability, while Lake Athabasca level appears to directly monitor overall water availability. The latter fluctuated systematically over the past millennium, with the highest levels occurring in concert with maximum glacier extent during the Little Ice Age, and the lowest during the 11th century, prior to medieval glacier expansion. Recent climate-driven hydrological change appears to be on a trajectory to even lower levels as high-elevation snow and glacier meltwater contributions both continue to decline

Marshall University Music Department Presents a Faculty Recital featuring Stephen Lawson, horn, assisted by, J. Steven Hall, marimba, percussion, Kay Lawson, bassoon, Peggy Johnston, piano

https://mds.marshall.edu/music_perf/1523/thumbnail.jp

DNA extraction from formalin-fixed tissue: new light from the Deep-Sea

DNA samples were extracted from ethanol and formalin-fixed decapod crustacean tissue using a new method based on Tetramethylsilane (TMS)-Chelex. It is shown that neither an indigestible matrix of cross-linked protein nor soluble PCR inhibitors impede PCR success when dealing with formalin-fixed material. Instead, amplification success from formalin-fixed tissue appears to depend on the presence of unmodified DNA in the extracted sample. A staining method that facilitates the targeting of samples with a high content of unmodified DNA is provided

Computational investigation in the aorta of children with Turner syndrome

The aortic arch has complex flow dynamics, with locations of arterial curvature and bifurcation known to be prone to endothelial dysfunction one of the early biological markers for atherosclerotic lesions that underlie most cardiovascular disease. This is particularly relevant to conditions of obesity, which is believed to accelerate the initiation and progression of vascular changes. A computational investigation found morphological differences between the patient-specific geometries to have a strong effect on the haemodynamic environment, and low wall shear stress at areas where atherosclerotic lesions have been suggested to develop preferentially

A computational investigation of cardiovascular haemodynamic abnormalities in turner syndrome patients

Girls with Turner syndrome (TS), a chromosomal condition in which a female has complete or partial absence of the second sex chromosome, present a unique group of patients, with an increased risk of cardiovascular disease. Congenital heart abnormalities occur in up to 50% of TS individuals and mortality rates are three times higher compared with the general population, with the most common cause of death being from cardiovascular disease [1-2]. We hypothesise that patients with TS present a greater variance in aortic arch morphology and haemodynamics than their healthy counterparts, because each TS patient is regarded as a unique anatomical and physiological case study. In this investigation, we present the first ever computational fluid dynamic analysis of TS children, with patient-specific physiologically realistic haemodynamic conditions. Computational models were used to analyse the arterial blood flow in TS children, who are known to present an increased risk of cardiovascular disease. Three-dimensional patient geometries of the aortic arch were reconstructed while numerical simulations were performed within a finite-volume method framework, using patient-specific phase-contrast MRI obtained boundary conditions. Velocity streamlines and time-dependent metrics, such as the timeaveraged wall shear stress (TAWSS) and oscillatory shear index (OSI), were computed for all models. Particular attention was paid to regions of low mean and oscillatory haemodynamic wall shear stresses as our current understanding of subclinical atherosclerosis links these blood flow-induced biomechanical stimuli with damage to the arterial vascular endothelium. Preliminary results have found morphological aortic differences between patients to have a strong effect on the haemodynamic environment and may be a marker for increased cardiovascular risk

Computational haemodynamics in Turner syndrome patient-specific aortae with PC-MRI obtained boundary conditions

Women with Turner syndrome (TS), a chromosomal condition in which a female has complete or partial absence of the second sex chromosome, present a unique group of patients, with an increased risk of cardiovascular disease. Mortality rates are three times higher in TS women compared with the general population, and life expectancy is reduced by up to 13 years –the most common cause of death being from cardiovascular disease. Congenital heart abnormalities occur in up to 50% of TS individuals, with bicuspid aortic valve, coarctation of the aorta, and thoracic aortic aneurysm being the most prevalent. Women with TS also have a greater underlying predisposition to metabolic abnormalities, such as obesity, which can exacerbate coronary artery disease, myocardial infarction, and stroke in TS adults. In this study, computational fluid dynamic (CFD)methods were used to analyse the arterial blood flow in children with Turner syndrome, who are known to present an increased risk of obesity and cardiovascular disease. Three-dimensional patient geometries were matched with patient-specific boundary conditions in the first unsteady simulation of blood flow in TS children. Morphological aortic differences between patients were found to have a strong effect on the haemodynamic environment and may be a marker for increased cardiovascular risk