Conditioning of Leverage Scores and Computation by QR Decomposition

The leverage scores of a full-column rank matrix A are the squared row norms of any orthonormal basis for range(A). We show that corresponding leverage scores of two matrices A and A + \Delta A are close in the relative sense, if they have large magnitude and if all principal angles between the column spaces of A and A + \Delta A are small. We also show three classes of bounds that are based on perturbation results of QR decompositions. They demonstrate that relative differences between individual leverage scores strongly depend on the particular type of perturbation \Delta A. The bounds imply that the relative accuracy of an individual leverage score depends on: its magnitude and the two-norm condition of A, if \Delta A is a general perturbation; the two-norm condition number of A, if \Delta A is a perturbation with the same norm-wise row-scaling as A; (to first order) neither condition number nor leverage score magnitude, if \Delta A is a component-wise row-scaled perturbation. Numerical experiments confirm the qualitative and quantitative accuracy of our bounds.Comment: This version has been accepted to SIMAX but has not yet gone through copy editin

Experimental Investigation of Unsteady Thrust Augmentation Using a Speaker-Driven Jet

An experimental investigation is described in which a simple speaker-driven jet was used as a pulsed thrust source (driver) for an ejector configuration. The objectives of the investigation were twofold. The first was to expand the experimental body of evidence showing that an unsteady thrust source, combined with a properly sized ejector generally yields higher thrust augmentation values than a similarly sized, steady driver of equivalent thrust. The second objective was to identify characteristics of the unsteady driver that may be useful for sizing ejectors, and for predicting the thrust augmentation levels that may be achieved. The speaker-driven jet provided a convenient source for the investigation because it is entirely unsteady (i.e., it has no mean velocity component) and because relevant parameters such as frequency, time-averaged thrust, and diameter are easily variable. The experimental setup will be described, as will the two main measurements techniques employed. These are thrust and digital particle imaging velocimetry of the driver. It will be shown that thrust augmentation values as high as 1.8 were obtained, that the diameter of the best ejector scaled with the dimensions of the emitted vortex, and that the so-called formation time serves as a useful dimensionless parameter by which to characterize the jet and predict performance

Excavation on the Moon: Regolith Collection for Oxygen Production and Outpost Site Preparation

The development of a robust regolith moving system for lunar and planetary processing and construction is critical to the NASA mission to the Moon and Mars. Oxygen production may require up to 200 metric tons of regolith collection per year; outpost site development may require several times this amount. This paper describes progress in the small vehicle implement development and small excavation system development. Cratos was developed as a platform for the ISRU project to evaluate the performance characteristics of a low center of gravity, small (0.75m x 0.75m x 0.3m), low-power, tracked vehicle performing excavation, load, haul, and dump operations required for lunar ISRU. It was tested on loose sand in a facility capable of producing level and inclined surfaces, and demonstrated the capability to pick up, carry, and dump sand, allowing it to accomplish the delivery of material to a site. Cratos has demonstrated the capability to pick up and deliver simulant to a bury an inflatable habitat, to supply an oxygen production plant, and to build a ramp

Understanding the treatment benefit of hyperimmune anti-influenza intravenous immunoglobulin (Flu-IVIG) for severe human influenza

Background: Antibody-based therapies for respiratory viruses are of increasing importance. The INSIGHT 006 trial administered anti-influenza hyperimmune intravenous immunoglobulin (Flu-IVIG) to patients hospitalized with influenza. Flu-IVIG treatment improved outcomes in patients with influenza B but showed no benefit for influenza A. Methods: To probe potential mechanisms of Flu-IVIG utility, sera collected from patients hospitalized with influenza A or B viruses (IAV or IBV) were analyzed for antibody isotype/subclass and Fcγ receptor (FcγR) binding by ELISA, bead-based multiplex, and NK cell activation assays. Results: Influenza-specific FcγR-binding antibodies were elevated in Flu-IVIG–infused IBV- and IAV-infected patients. In IBV-infected participants (n = 62), increased IgG3 and FcγR binding were associated with more favorable outcomes. Flu-IVIG therapy also improved the odds of a more favorable outcome in patients with low levels of anti-IBV Fc-functional antibody. Higher FcγR-binding antibody was associated with less favorable outcomes in IAV-infected patients (n = 50), and Flu-IVIG worsened the odds of a favorable outcome in participants with low levels of anti-IAV Fc-functional antibody. Conclusion: These detailed serological analyses provide insights into antibody features and mechanisms required for a successful humoral response against influenza, suggesting that IBV-specific, but not IAV-specific, antibodies with Fc-mediated functions may assist in improving influenza outcome. This work will inform development of improved influenza immunotherapies

Ursinus College Alumni Journal, November 1960

President\u27s page • Founders\u27 Day • Wayne Brown memorial • Ritter receives degree • Admissions report • Alumnae in Who\u27s Who • Dr. Helfferich honored • Brother of Dalai Lama at Ursinus • Ursinus Women\u27s Club • Old Timers\u27 Day • Psychology\u27s place in a liberal education • The faculty, cornered • Forsan et haec • Education - Scottish and American • 1960 football results • Vernon Morgan, \u2761 Ursinus\u27 greatest runner • Seven years of alumni sponsorship completed: $188,473 collected for Ursinus in this period • Dr. Helfferich speaks • Loyalty Fund all stars • 1960 Loyalty Fund report • Advance Loyalty Fund report for 1961 • Results of the 1960 Loyalty Fund campaign • Contributors for the 1960 Loyalty Fund campaign • New reunion schedule to begin in 1961 • News about ourselves • Weddings • Births • Necrologyhttps://digitalcommons.ursinus.edu/alumnijournal/1069/thumbnail.jp

Cratos: A Simple Low Power Excavation and Hauling System for Lunar Oxygen Production and General Excavation Tasks

The development of a robust excavating and hauling system for lunar and planetary excavation is critical to the NASA mission to the Moon and Mars. Cratos was developed as a low center of gravity, small (.75m x .75m x 0.3m), low power tracked test vehicle. The vehicle was modified to excavate and haul because it demonstrated good performance capabilities in a laboratory and field testing. Tested on loose sand in the SLOPE facility, the vehicle was able to pick up, carry, and dump sand, allowing it to accomplish the standard requirements delivery of material to a lunar oxygen production site. Cratos can pick up and deliver raw material to a production plant, as well as deliver spent tailings to a disposal site. The vehicle can complete many other In-Situ Resource Utilization (ISRU) excavation chores and in conjunction with another vehicle or with additional attachments may be able to accomplish all needed ISRU tasks

Selection of antigenically advanced variants of seasonal influenza viruses

Influenza viruses mutate frequently, necessitating constant updates of vaccine viruses. To establish experimental approaches that may complement the current vaccine strain selection process, we selected antigenic variants from human H1N1 and H3N2 influenza virus libraries possessing random mutations in the globular head of the haemagglutinin protein (which includes the antigenic sites) by incubating them with human and/or ferret convalescent se

Habitability of the Phoenix landing site

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95488/1/jgre2706.pd

Reactive oxygen species in phagocytic leukocytes

Phagocytic leukocytes consume oxygen and generate reactive oxygen species in response to appropriate stimuli. The phagocyte NADPH oxidase, a multiprotein complex, existing in the dissociated state in resting cells becomes assembled into the functional oxidase complex upon stimulation and then generates superoxide anions. Biochemical aspects of the NADPH oxidase are briefly discussed in this review; however, the major focus relates to the contributions of various modes of microscopy to our understanding of the NADPH oxidase and the cell biology of phagocytic leukocytes

Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis

To optimise fecal sampling for reproducible analysis of the gut microbiome, we compared different methods of sample collection and sequencing of 16S rRNA genes at two centers. Samples collected from six individuals on three consecutive days were placed in commercial collection tubes (OMNIgeneGut OMR-200) or in sterile screw-top tubes in a home fridge or home freezer for 6-24 h, before transfer and storage at-80 °C. Replicate samples were shipped to centers in Australia and the USA for DNA extraction and sequencing by their respective PCR protocols, and analysed with the same bioinformatic pipeline. Variation in gut microbiome was dominated by differences between individuals. Minor differences in the abundance of taxa were found between collection-processing methods and day of collection, and between the two centers. We conclude that collection with storage and transport at 4 °C within 24 h is adequate for 16S rRNA analysis of the gut microbiome. Other factors including differences in PCR and sequencing methods account for relatively minor variation compared to differences between individuals