17,115 research outputs found
Temporal patterns of gene expression via nonmetric multidimensional scaling analysis
Motivation: Microarray experiments result in large scale data sets that
require extensive mining and refining to extract useful information. We have
been developing an efficient novel algorithm for nonmetric multidimensional
scaling (nMDS) analysis for very large data sets as a maximally unsupervised
data mining device. We wish to demonstrate its usefulness in the context of
bioinformatics. In our motivation is also an aim to demonstrate that
intrinsically nonlinear methods are generally advantageous in data mining.
Results: The Pearson correlation distance measure is used to indicate the
dissimilarity of the gene activities in transcriptional response of cell
cycle-synchronized human fibroblasts to serum [Iyer et al., Science vol. 283,
p83 (1999)]. These dissimilarity data have been analyzed with our nMDS
algorithm to produce an almost circular arrangement of the genes. The temporal
expression patterns of the genes rotate along this circular arrangement. If an
appropriate preparation procedure may be applied to the original data set,
linear methods such as the principal component analysis (PCA) could achieve
reasonable results, but without data preprocessing linear methods such as PCA
cannot achieve a useful picture. Furthermore, even with an appropriate data
preprocessing, the outcomes of linear procedures are not as clearcut as those
by nMDS without preprocessing.Comment: 11 pages, 6 figures + online only 2 color figures, submitted to
Bioinformatic
Nanowire Acting as a Superconducting Quantum Interference Device
We present the results from an experimental study of the magneto-transport of
superconducting wires of amorphous Indium-Oxide, having widths in the range 40
- 120 nm. We find that, below the superconducting transition temperature, the
wires exhibit clear, reproducible, oscillations in their resistance as a
function of magnetic field. The oscillations are reminiscent of those which
underlie the operation of a superconducting quantum interference device.Comment: 4 pages, 4 figures, 1 tabl
Aperiodic tumbling of microrods advected in a microchannel flow
We report on an experimental investigation of the tumbling of microrods in
the shear flow of a microchannel (40 x 2.5 x 0.4 mm). The rods are 20 to 30
microns long and their diameters are of the order of 1 micron. Images of the
centre-of-mass motion and the orientational dynamics of the rods are recorded
using a microscope equipped with a CCD camera. A motorised microscope stage is
used to track individual rods as they move along the channel. Automated image
analysis determines the position and orientation of a tracked rods in each
video frame. We find different behaviours, depending on the particle shape, its
initial position, and orientation. First, we observe periodic as well as
aperiodic tumbling. Second, the data show that different tumbling trajectories
exhibit different sensitivities to external perturbations. These observations
can be explained by slight asymmetries of the rods. Third we observe that after
some time, initially periodic trajectories lose their phase. We attribute this
to drift of the centre of mass of the rod from one to another stream line of
the channel flow.Comment: 14 pages, 8 figures, as accepted for publicatio
High-Yield of Memory Elements from Carbon Nanotube Field-Effect Transistors with Atomic Layer Deposited Gate Dielectric
Carbon nanotube field-effect transistors (CNT FETs) have been proposed as
possible building blocks for future nano-electronics. But a challenge with CNT
FETs is that they appear to randomly display varying amounts of hysteresis in
their transfer characteristics. The hysteresis is often attributed to charge
trapping in the dielectric layer between the nanotube and the gate. This study
includes 94 CNT FET samples, providing an unprecedented basis for statistics on
the hysteresis seen in five different CNT-gate configurations. We find that the
memory effect can be controlled by carefully designing the gate dielectric in
nm-thin layers. By using atomic layer depositions (ALD) of HfO and
TiO in a triple-layer configuration, we achieve the first CNT FETs with
consistent and narrowly distributed memory effects in their transfer
characteristics.Comment: 6 pages, 3 figures; added one reference, text reformatted with
smaller addition
Landau-Zener-Stuckelberg Interferometry of a Single Electron Charge Qubit
We perform Landau-Zener-Stuckelberg interferometry on a single electron GaAs
charge qubit by repeatedly driving the system through an avoided crossing. We
observe coherent destruction of tunneling, where periodic driving with specific
amplitudes inhibits current flow. We probe the quantum dot occupation using a
charge sensor, observing oscillations in the qubit population resulting from
the microwave driving. At a frequency of 9 GHz we observe excitation processes
driven by the absorption of up to 17 photons. Simulations of the qubit
occupancy are in good agreement with the experimental data.Comment: Related papers at http://pettagroup.princeton.ed
Internally Electrodynamic Particle Model: Its Experimental Basis and Its Predictions
The internally electrodynamic (IED) particle model was derived based on
overall experimental observations, with the IED process itself being built
directly on three experimental facts, a) electric charges present with all
material particles, b) an accelerated charge generates electromagnetic waves
according to Maxwell's equations and Planck energy equation and c) source
motion produces Doppler effect. A set of well-known basic particle equations
and properties become predictable based on first principles solutions for the
IED process; several key solutions achieved are outlined, including the de
Broglie phase wave, de Broglie relations, Schr\"odinger equation, mass,
Einstein mass-energy relation, Newton's law of gravity, single particle self
interference, and electromagnetic radiation and absorption; these equations and
properties have long been broadly experimentally validated or demonstrated. A
specific solution also predicts the Doebner-Goldin equation which emerges to
represent a form of long-sought quantum wave equation including gravity. A
critical review of the key experiments is given which suggests that the IED
process underlies the basic particle equations and properties not just
sufficiently but also necessarily.Comment: Presentation at the 27th Int Colloq on Group Theo Meth in Phys, 200
Atomic Processes in Planetary Nebulae and H II Regions
Spectroscopic studies of Planetary Nebulae (PNe) and H {\sc ii} regions have
driven much development in atomic physics. In the last few years the
combination of a generation of powerful observatories, the development of ever
more sophisticated spectral modeling codes, and large efforts on mass
production of high quality atomic data have led to important progress in our
understanding of the atomic spectra of such astronomical objects. In this paper
I review such progress, including evaluations of atomic data by comparisons
with nebular spectra, detection of spectral lines from most iron-peak elements
and n-capture elements, observations of hyperfine emission lines and analysis
of isotopic abundances, fluorescent processes, and new techniques for
diagnosing physical conditions based on recombination spectra. The review is
directed toward atomic physicists and spectroscopists trying to establish the
current status of the atomic data and models and to know the main standing
issues.Comment: 9 pages, 1 figur
Dynamical study on polaron formation in a metal/polymer/metal structure
By considering a metal/polymer/metal structure within a tight-binding
one-dimensional model, we have investigated the polaron formation in the
presence of an electric field. When a sufficient voltage bias is applied to one
of the metal electrodes, an electron is injected into the polymer chain, then a
self-trapped polaron is formed at a few hundreds of femtoseconds while it moves
slowly under a weak electric field (not larger than V/cm).
At an electric field between V/cm and V/cm,
the polaron is still formed, since the injected electron is bounded between the
interface barriers for quite a long time. It is shown that the electric field
applied at the polymer chain reduces effectively the potential barrier in the
metal/polymer interface
Observation of the Dynamical Casimir Effect in a Superconducting Circuit
One of the most surprising predictions of modern quantum theory is that the
vacuum of space is not empty. In fact, quantum theory predicts that it teems
with virtual particles flitting in and out of existence. While initially a
curiosity, it was quickly realized that these vacuum fluctuations had
measurable consequences, for instance producing the Lamb shift of atomic
spectra and modifying the magnetic moment for the electron. This type of
renormalization due to vacuum fluctuations is now central to our understanding
of nature. However, these effects provide indirect evidence for the existence
of vacuum fluctuations. From early on, it was discussed if it might instead be
possible to more directly observe the virtual particles that compose the
quantum vacuum. 40 years ago, Moore suggested that a mirror undergoing
relativistic motion could convert virtual photons into directly observable real
photons. This effect was later named the dynamical Casimir effect (DCE). Using
a superconducting circuit, we have observed the DCE for the first time. The
circuit consists of a coplanar transmission line with an electrical length that
can be changed at a few percent of the speed of light. The length is changed by
modulating the inductance of a superconducting quantum interference device
(SQUID) at high frequencies (~11 GHz). In addition to observing the creation of
real photons, we observe two-mode squeezing of the emitted radiation, which is
a signature of the quantum character of the generation process.Comment: 12 pages, 3 figure
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