1 research outputs found
Cross-Linking of a Hydrophilic, Antimicrobial Polycation toward a Fast-Swelling, Antimicrobial Superabsorber and Interpenetrating Hydrogel Networks with Long Lasting Antimicrobial Properties
A hemocompatible,
antimicrobial 3,4en-ionene (PBI) derived by polyaddition of <i>trans</i>-1,4-dibromo-2-butene and <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetramethyl-1,3-propanediamine
was cross-linked via its bromine end groups using trisÂ(2-aminoethyl)Âamine
(TREN) to form a fast-swelling, antimicrobial superabsorber. This
superabsorber is taking up the 30-fold of its weight in 60 s and the
granulated material is taking up 96-fold of its weight forming a hydrogel.
It fully prevents growth of the bacterium <i>Staphylococcus aureus</i>. The PBI network was swollen with 2-hydroxyethyl acrylate and glycerol
dimethacrylate followed by photopolymerization to form an interpenetrating
hydrogel (IPH) with varying PBI content in the range of 2.0 to 7.8
wt %. The nanophasic structure of the IPH was confirmed by atomic
force microscopy and transmission electron microscopy. The bacterial
cells of the nosocomial strains <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i> are killed on the IPH even at the lowest PBI concentration. The
antimicrobial activity was retained after washing the hydrogels for
up to 4 weeks. The IPHs show minor leaching of PBI far below its antimicrobial
active concentration using a new quantitative test for PBI detection
in solution. This leaching was shown to be insufficient to form an
inhibition zone and killing bacterial cells in the surroundings of
the IPH