Low-grade retrogression of a high-temperature metamorphic core complex: Naxos, Cyclades, Greece

Retrogressive deformation and metamorphism are often reported from the main low-angle shear zones and detachments of metamorphic core complexes, but their importance is not sufficiently emphasized for the footwall interior. In order to contribute to a better understanding of exhumation-related retrogression processes within and at the top of metamorphic core complexes, an integrated detailed microstructural, textural, 40Ar/39Ar geochronological, and thermobarometric study on the Naxos metamorphic core complex within the Aegean Sea is presented that provides a new perspective on low-grade retrogression during exhumation through shallow ductile levels. We found variable retrogressive deformation within the Naxos metamorphic core complex, which even pervasively affected significant portions of the migmatite-grade metamorphic core and remnant high-pressure areas of the metamorphic core complex, where retrogression led to pervasive formation of new fabrics within greenschist-facies metamorphic conditions during brittle-ductile transition. Within a continuum of retrogression, 40Ar/39Ar white mica dating allowed us to deduce three retrogressive ages at 16.52 ± 0.39 Ma (within the Naxos metamorphic core complex), 12.6 ± 0.28 Ma (Moutsounas detachment shear zone on the eastern boundary of the metamorphic core complex), and 10.43 ± 0.44 Ma to 8.40 ± 0.76 Ma (last ductile activity along the Naxos-Paros shear zone to the north of the metamorphic core complex). A further stage of retrogression at 12−11 Ma occurred along distinct low-angle normal faults within the middle Miocene Naxos Granite. Retrogressive microstructures, low-temperature calcite fabrics in marbles, and chloritization in metapelites (at temperatures of ∼350−130 °C) in the metamorphic core complex core resulted mainly from late-stage E-W shortening and folding. Late-stage flow of hydrous fluids resulted in resetting of fabrics and enhancement of ductile deformation. The middle−late Miocene retrogression events are also reflected by a similarly aged tectonic collapse basin in the hanging-wall unit above the detachment. The wide temporal range of retrogression within the Naxos metamorphic core complex coincides in age with retrogressive deformation within other metamorphic core complexes of the Aegean Sea. We interpret the long temporal range of retrogression to reflect outward, southwestward retreat of the subduction and sequential activation of major detachment zones

Regional differences in health care of patients with inflammatory bowel disease in Germany

Background: The regional availability of specialized physicians is an important aspect in healthcare of patients with IBD. The association between physician density and healthcare is not yet clear. Most studies did not consider district type, which reflects population density. Our research question was, “Do specialist density and district type influence the healthcare of IBD patients in Germany?” Methods: We combined a claims dataset from a German health insurance fund with population and physician data. Four main aspects were investigated: regular specialist visits, drug therapies, surveillance colonoscopy, and IBD-related hospitalizations. Various regression analyses were performed. Results: The study cohort was comprised of 21,771 individuals, including 9282 patients with Crohn disease and 12,489 patients with ulcerative colitis. Patients who were living in districts with higher specialist densities were more likely to attend specialist visits on a regular basis. No difference in the frequencies of TNF-alpha inhibitor therapies was found. However, individuals from urban areas were more likely to receive a permanent immunosuppressive therapy with continuous specialist support. Conclusions: The results revealed that some aspects had positive effects on the probability of implementing healthcare in accordance with pathways and guidelines. No clear evidence of a general healthcare undersupply in rural areas was found.DF

Characterization data of reference cement CEM I 42.5 R used for priority program DFG SPP 2005 “Opus Fluidum Futurum – Rheology of reactive, multiscale, multiphase construction materials”

A thorough characterization of starting materials is the precondition for further research, especially for cement, which contains various phases and presents quite a complex material for fundamental scientific investigation. In the paper at hand, the characterization data of the reference cement CEM I 42.5 R used within the priority program 2005 of the German Research Foundation (DFG SPP 2005) are presented from the aspects of chemical and mineralogical compositions as well as physical and chemical properties. The data were collected based on tests conducted by nine research groups involved in this cooperative program. For all data received, the mean values and the corresponding errors were calculated. The results shall be used for the ongoing research within the priority program.DFG, 313773090, SPP 2005: Opus Fluidum Futurum - Rheologie reaktiver, multiskaliger, mehrphasiger Baustoffsystem

Geochemical and isotopic evidence for Carboniferous rifting : mafic dykes in the central Sanandaj-Sirjan zone (Dorud-Azna, West Iran)

In this paper, we present detailed field observations, chronological, geochemical and SrNd isotopic data and discuss the petrogenetic aspects of two types of mafic dykes, of alkaline to subalkaline nature. The alkaline mafic dykes exhibit a cumulate to foliated texture and strike NWSE, parallel to the main trend of the region. The 40Ar/39Ar amphibole age of 321.32 0.55 Ma from an alkaline mafic dyke is interpreted as an indication of Carboniferous cooling through ca. 550 C after intrusion of the dyke into the granitic Galeh-Doz orthogneiss and Amphibolite-Metagabbro units, the latter with Early Carboniferous amphibolite facies grade metamorphism and containing the Dare-Hedavand metagabbro with a similar Carboniferous age. The alkaline and subalkaline mafic dykes can be geochemically categorized into those with light REE-enriched patterns [(La/Yb)N = 8.329.28] and others with a rather flat REE pattern [(La/Yb)N = 1.16] and with a negative Nb anomaly. Together, the mafic dykes show oceanic island basalt to MORB geochemical signature, respectively. This is consistent, as well, with the (Tb/Yb)PM ratios. The alkaline mafic dykes were formed within an enriched mantle source at depths of 90 km, generating a suite of alkaline basalts. In comparison, the subalkaline mafic dykes were formed within more depleted mantle source at depths of 90 km. The subalkaline mafic dyke is characterized by 87Sr/86Sr ratio of 0.706 and positive Nd(t) value of + 0.77, whereas 87Sr/86Sr ratio of 0.708 and Nd(t) value of + 1.65 of the alkaline mafic dyke, consistent with the derivation from an enriched mantle source. There is no evidence that the mafic dykes were affected by significant crustal contamination during emplacement. Because of the similar age, the generation of magmas of alkaline mafic dykes and of the Dare-Hedavand metagabbro are assumed to reflect the same process of lithospheric or asthenospheric melting. Carboniferous back-arc rifting is the likely geodynamic setting of mafic dyke generation and emplacement. In contrast, the subalkaline mafic sill is likely related to the emplacement of the Jurassic Darijune gabbro.(VLID)223441

Growing old at home – A randomized controlled trial to investigate the effectiveness and cost-effectiveness of preventive home visits to reduce nursing home admissions: study protocol [NCT00644826]

<p>Abstract</p> <p>Background</p> <p>Regarding demographic changes in Germany it can be assumed that the number of elderly and the resulting need for long term care is increasing in the near future. It is not only an individual's interest but also of public concern to avoid a nursing home admission. Current evidence indicates that preventive home visits can be an effective way to reduce the admission rate in this way making it possible for elderly people to stay longer at home than without home visits. As the effectiveness and cost-effectiveness of preventive home visits strongly depends on existing services in the social and health system existing international results cannot be merely transferred to Germany. Therefore it is necessary to investigate the effectiveness and cost-effectiveness of such an intervention in Germany by a randomized controlled trial.</p> <p>Methods</p> <p>The trial is designed as a prospective multi-center randomized controlled trial in the cities of Halle and Leipzig. The trial includes an intervention and a control group. The control group receives usual care. The intervention group receives three additional home visits by non-physician health professionals (1) geriatric assessment, (2) consultation, (3) booster session.</p> <p>The nursing home admission rate after 18 months will be defined as the primary outcome. An absolute risk reduction from a 20% in the control-group to a 7% admission rate in the intervention group including an assumed drop out rate of 30% resulted in a required sample size of N = 320 (n = 160 vs. n = 160).</p> <p>Parallel to the clinical outcome measurement the intervention will be evaluated economically. The economic evaluation will be performed from a society perspective.</p> <p>Discussion</p> <p>To the authors' knowledge for the first time a trial will investigate the effectiveness and cost-effectiveness of preventive home visits for people aged 80 and over in Germany using the design of a randomized controlled trial. Thus, the trial will contribute to the existing evidence on preventive home visits especially in Germany.</p

Precision and accuracy of single-molecule FRET measurements - a multi-laboratory benchmark study

Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However, generalized protocols and FRET standards to ensure the reproducibility and accuracy of measurements of FRET efficiencies are currently lacking. Here we report the results of a comparative blind study in which 20 labs determined the FRET efficiencies (E) of several dye-labeled DNA duplexes. Using a unified, straightforward method, we obtained FRET efficiencies with s.d. between ±0.02 and ±0.05. We suggest experimental and computational procedures for converting FRET efficiencies into accurate distances, and discuss potential uncertainties in the experiment and the modeling. Our quantitative assessment of the reproducibility of intensity-based smFRET measurements and a unified correction procedure represents an important step toward the validation of distance networks, with the ultimate aim of achieving reliable structural models of biomolecular systems by smFRET-based hybrid methods

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements