Allogeneic Hematopoietic Cell Transplantation for Older Adults with Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a disease that affects adults aged 65 years and above, and survival in this population is poor. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for these patients but is underutilized due to frequent comorbidities and perceived higher risk of treatment-related mortality and non-relapse mortality. Increasing data supports the utility of allo-HCT in fit older patients after intensive chemotherapy resulting in improvement of outcomes. With the development of reduced intensity and non-myeloablative conditioning regimens that are associated with lower rates of treatment-related toxicity and mortality, this has allowed more older patients with AML to receive allo-HCT. In this review, we provide some guidance on appropriate selection of older patients as transplant candidates, benefits and risks associated with allo-HCT, conditioning regimen choice, and stem cell transplant sources as they relate to the conduct of stem cell transplantation in older patients

An Unusual Case of Multiple Myeloma with Light-Chain Cast Nephropathy Secondary to a Very Large Plasmacytoma without Bone Marrow Involvement

Here, we report a case of a patient who presented to Strong Memorial Hospital with new-onset renal failure and anemia and was found to have multiple myeloma with lambda light-chain cast nephropathy secondary to a very large (14 cm × 14 cm × 12 cm) plasmacytoma without bone marrow involvement. This case is notable as solitary plasmacytomas are almost never seen with concomitant myeloma-defining CRAB criteria or significantly elevated serum free light-chain ratios. Although solitary plasmacytomas are typically definitively treated with radiation, this case highlights that systemic treatment may be helpful in certain clinical scenarios

Rochester Regional Health Orthopedic Infection Prevention Symposium, 2023

RRH Orthopedic Infection Prevention Symposium, April 22, 2023. Introduction/Scope of the Problem/The IP Bundle, M. Gordon Whitbeck, Jr., MD NYS/NHSN Infection Definitions, Jennifer James, RN, BSN, CIC Patient Selection and Optimization, Timothy Wagner, MD Pre-Op Education/Decolonization/Nutrition, Jodi Moore, RN Intraoperative Considerations, Rachel Wakefield, MS, RN and Christopher Jorstad, RN Antibotic Prophylaxis/Irrigation/Local Antibiotic Use - Arthroplasty, Sean Childs, MD Antibotic Use/Irrigation/Local Antibiotic Use - Spine, Christian P. DiPaola, MD Post-Op Wound Care/Floor Care, Nicole Rickards, RN Management of the Draining Wound/Intraop Culture Technique/Clean Fascial Closure, Jason Lipof, MD Panel Discussion, Drs. M. Klotz (Moderator), T. Wagner, J. Lipof, S. Childs, S. Rajamanickam, E. Weiss, N. Loffredo, C. DiPaola, M. Gordon Whitbeck, Jr. Closing Remarks/Proposal for Consensus, Michael Klotz, M