Multidisciplinary thesauri in Internet

Dentro de la serie de trabajos sobre tesauros en acceso abierto presentes en Internet, se presentan, en esta ocasión, los multidisciplinares y aquellos que, aún estando dedicados a una disciplina, recogen términos de diversas materias.Peer reviewe

Personnel Training System As A Management Component Of A Socially Responsible Organisation

The paper describes some practical aspects to justify the need for training and motivating staff to achieve the set results of a small business enterprise. The paper considers a commercial enterprise with the headcount up to 40 people. For such enterprises, commercial success, ensuring the well-being of the company employees, is closely related to the quality of their work. To achieve the required level of the personnel performance, a system of personnel training has been developed. The system is related to the organisation's goals on the basis of the balanced scorecard (BSC) system methodology. Methods of statistical data processing were used to study the current state of affairs and identify the factors that have the greatest impact on the effectiveness of the organisation. To identify some possible problems in the main process of the organisation, the methodology of risk analysis was used. As a result of the work, staff activity standards have been developed, including the criteria for the staff performance assessment. The head of the organisation has been given an opportunity to manage on the basis of the actual data on the main process effectiveness

Создание системы управления жалобами в организации

Одним из главных факторов образования конкурентоспособности является результативное управление, во всех сферах деятельности предприятия. Цель работы создание стандарта организации "Порядок рассмотрения и удовлетворения рекламации от потребителя" и разработка алгоритма реализации данного процесса для поддержания системы менеджмента качества. Предметом исследования является система управления жалобами в организации. Результатом внедрения системы рассмотрения жалоб в организации является то, что система менеджмента становится более ориентированной на заказчиков. Это позволяет укрепить контакты со своими потребителями, а так же улучшить качество продукции с помощью выполнения и соблюдения всех временных сроков, требований и последовательностей действий, прописанных в стандарте организации.One of the main factors for the formation of competitiveness is effective management, in all areas of the enterprise.The purpose of the work is the creation of the organization's standard "Order of consideration and satisfaction of the complaint from the consumer" and the development of an algorithm for implementing this process to maintain the quality management system. The subject of the study is the complaint management system in the organization. The result of the introduction of the complaints system in the organization is that the management system becomes more customer-oriented. This allows us to strengthen contacts with our customers, improve the quality of products through the implementation and compliance with all the time limits, the requirements prescribed in the standard

VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis

Chronic pain can develop in response to conditions such as inflammatory arthritis. The central mechanisms underlying the development and maintenance of chronic pain in humans are not well elucidated although there is evidence for a role of microglia and astrocytes. However in pre-clinical models of pain, including models of inflammatory arthritis, there is a wealth of evidence indicating roles for pathological glial reactivity within the CNS. In the spinal dorsal horn of rats with painful inflammatory arthritis we found both a significant increase in CD11b+ microglia-like cells and GFAP+ astrocytes associated with blood vessels, and the number of activated blood vessels expressing the adhesion molecule ICAM-1, indicating potential glio-vascular activation. Using pharmacological interventions targeting VEGFR2 in arthritic rats, to inhibit endothelial cell activation, the number of dorsal horn ICAM-1+ blood vessels, CD11b+ microglia and the development of secondary mechanical allodynia, an indicator of central sensitization, were all prevented. Targeting endothelial VEGFR2 by inducible Tie2-specific VEGFR2 knock-out also prevented secondary allodynia in mice and glio-vascular activation in the dorsal horn in response to inflammatory arthritis. Inhibition of VEGFR2 in vitro significantly blocked ICAM-1-dependent monocyte adhesion to brain microvascular endothelial cells, when stimulated with inflammatory mediators TNFa and VEGF-A165a. Taken together our findings suggest that a novel VEGFR2-mediated spinal cord gliovascular mechanism may promote peripheral CD11b+ circulating cell transmigration into the CNS parenchyma and contribute to the development of chronic pain in inflammatory arthritis. We hypothesise that preventing this glio-vascular activation and circulating cell translocation into the spinal cord could be a new therapeutic strategy for pain caused by rheumatoid arthritis

Allylcalcium complexes : synthesis, reactivity and application in homogeneous catalysis

The main objective of the present work is to study preparation, coordination behavior and basic reactivity patterns of allylcalcium compounds. Examples for catalytic reactions of the resulting calcium compounds are given to evaluate the scope of applications. The first part describes the isolation of 1-alkenyl calcium complexes and their structural properties in solution and in the solid state. Model reactions with carbonyls and I2 reveal a distinct reactivity of bis(allyl)calcium towards electrophiles. The isolation of an alkylcalcium complex is briefly described. The second part presents the coordination behavior of bis(allyl)calcium in the presence of (aza)crown ethers. Despite isolation of an unprecedented crown ether complex bearing one monohapto- and one trihapto-allyl ligand, the basicity of the latter ligands leads to ether cleavage reactions. The decomposition pathway of the obtained adducts is described. The third part of this work reports on reactions of bis(allyl)calcium with Brønsted and Lewis acids and in situ generated allylcalcium monocations. Whereas ion pairs containing [Ca(C3H5)]+ are smoothly formed with several reagents, their isolation is prevented by ligand exchange equilibria towards the homoleptic species. A brief comparison of the activity in alpha-olefin polymerization is given. The parent compound bis(allyl)calcium is active in the polymerization of 1,3-butadiene but inactive in the polymerization of ethylene. Compounds bearing cationic [Ca(C3H5)]+ show no activity in the polymerization of 1,3-butadiene or ethylene. The fourth part focuses on the reactivity of bis(allyl)calcium towards pyridine and furan derivatives. A series of insertion and C-H bond activation products was isolated from reactions with N-heteroaryls and fully characterized. Mechanisms are studied and show a distinct balance between nucleophilicity and basicity of the employed allylcalcium compounds. The reactivity towards furans is found to result in undefined product mixtures. The last part of this work describes the reactivity of allylcalcium complexes towards dihydrogen, silanes and other hydrogenating agents. Special emphasis is given on the isolation a cationic calcium hydride cluster with a hypervalent hydridosilicate anion. The isolation of a ketyl radical complex hints at a redox non-innocent behavior of this ion pair. This unprecedented compound is active in hydrogenation of an 1-alkene with H2

Allylcalcium complexes : synthesis, reactivity and application in homogeneous catalysis

The main objective of the present work is to study preparation, coordination behavior and basic reactivity patterns of allylcalcium compounds. Examples for catalytic reactions of the resulting calcium compounds are given to evaluate the scope of applications. The first part describes the isolation of 1-alkenyl calcium complexes and their structural properties in solution and in the solid state. Model reactions with carbonyls and I2 reveal a distinct reactivity of bis(allyl)calcium towards electrophiles. The isolation of an alkylcalcium complex is briefly described. The second part presents the coordination behavior of bis(allyl)calcium in the presence of (aza)crown ethers. Despite isolation of an unprecedented crown ether complex bearing one monohapto- and one trihapto-allyl ligand, the basicity of the latter ligands leads to ether cleavage reactions. The decomposition pathway of the obtained adducts is described. The third part of this work reports on reactions of bis(allyl)calcium with Brønsted and Lewis acids and in situ generated allylcalcium monocations. Whereas ion pairs containing [Ca(C3H5)]+ are smoothly formed with several reagents, their isolation is prevented by ligand exchange equilibria towards the homoleptic species. A brief comparison of the activity in alpha-olefin polymerization is given. The parent compound bis(allyl)calcium is active in the polymerization of 1,3-butadiene but inactive in the polymerization of ethylene. Compounds bearing cationic [Ca(C3H5)]+ show no activity in the polymerization of 1,3-butadiene or ethylene. The fourth part focuses on the reactivity of bis(allyl)calcium towards pyridine and furan derivatives. A series of insertion and C-H bond activation products was isolated from reactions with N-heteroaryls and fully characterized. Mechanisms are studied and show a distinct balance between nucleophilicity and basicity of the employed allylcalcium compounds. The reactivity towards furans is found to result in undefined product mixtures. The last part of this work describes the reactivity of allylcalcium complexes towards dihydrogen, silanes and other hydrogenating agents. Special emphasis is given on the isolation a cationic calcium hydride cluster with a hypervalent hydridosilicate anion. The isolation of a ketyl radical complex hints at a redox non-innocent behavior of this ion pair. This unprecedented compound is active in hydrogenation of an 1-alkene with H2

Reactions of CO₂ with Heteroleptic Zinc and Zinc–NHC Complexes

The heteroleptic compound Cp*ZnC₆F₅ (<b>1</b>) reacts with carbenes to give Cp*ZnC₆F₅(L) (L = I<i>t</i>Bu, <b>2</b>; IDipp, <b>3</b>; IMes, <b>4</b>), in which the presence of the carbene ligand induces slippage of the C₅Me₅ ligands. The species <b>1</b> and <b>2</b> react with CO₂ to give the hexameric species [(C₅Me₅CO₂)­ZnC₆F₅]₆ (<b>5</b>) and the monomeric (C₅Me₅CO₂)­ZnC₆F₅(I<i>t</i>Bu) (<b>6</b>), respectively