Biosemiotics comprehension of PrP code and prion disease

Producción CientíficaPrions or PrPSc (prion protein, Scrapie isoform) are proteins with an aberrant three-dimensional conformation that present the ability to alter the three-dimensional structure of natively folded PrPC (prion protein, cellular isoform) inducing its abnormal folding, giving raise to neurological diseases known as Transmissible spongiforms encephalopathies (TSEs) or prion diseases. In this work, through a biosemiotic study, we will analyze the molecular code of meanings that are known in the molecular pathway of PrPC and how it is altered in prion diseases. This biosemiotic code presents a socio-semiotic correlate in organisms that could be unraveled with the ultimate goal of understanding the code of signs that mediates the process. Finally, we will study recent works that indicate possible relationships in the code between prion proteins and other proteins such as the tau protein and alpha-synuclein to evaluate if it is possible that there is a semiotic expansion of the PrP code and prion diseases in the meaning recently expounded by Prusiner, winner of the Nobel Prize for describing these unusual pathological processes

Generador de currículos en diferentes estilos: aplicación web

Este proyecto recoge la creación de una aplicación web destinada a realizar el Currículum Vitae en diferentes formatos de forma personalizada. Dicha aplicación servirá de soporte a distintos usuarios, que podrán gestionar sus datos profesionales de forma automatizada. Se les permitirá generar distintos formatos y estilos del mismo sin necesidad de rellenar sus datos de forma repetitiva y ajustándose a la normativa necesaria para el mismo. Proporciona una herramienta colaborativa en la cual los diferentes usuarios podrán crear y compartir estilos y secciones del documento, manteniendo siempre la privacidad en sus datos. Para esta aplicación se ha incluido a modo de ejemplo el formato Europeo requerido en los currículos del personal docente de la universidad UCM (Universidad Complutense de Madrid). [ABSTRACT] This project includes the creation of a web application designed to make your CV in different formats in a personalized way. This application will support different users, they can automatically manage their business data. They will generate different formats and styles of the same without filling your data on repetitive times and according to the regulations necessary for it. It provides a collaborative tool in which different users can create and share styles and sections of the document, while maintaining privacy in their data. For this application has been included as an example the European format required in the curricula of the faculty of the UCM University (Universidad Complutense de Madrid)

Effects of hydroxyapatite filler on long-term hydrolytic degradation of PLLA/PCL

[EN] Poly(L-lactic acid)(PLLA)/poly(epsilon-caprolactone)(PCL)/hydroxyapatite(HAp) composites appear as promising materials for healing large bone defects. Highly porous PLLA/PCL scaffolds, 80/20, 20/80 weight ratios, porosity >85%, were prepared by a dual technique of freeze extraction and porogen leaching, with and without HAp. A double pore structure was obtained, with interconnected macroporosity together with interconnected microporosity. Subsequent long-term (78 weeks = 1.5 years) hydrolytic degradation behavior was investigated in terms of the samples' mechanical properties, molecular weight (M-w), mass changes, thermal characteristics, X-ray Diffraction and Thermogravimetric Analysis. Elastic modulus and yield strength of as-synthesized scaffolds were higher for PLLA rich blends and including the inorganic phase does not lead to a mechanical strengthening in these materials. Nevertheless, after 30 weeks of degradation, PLLA rich scaffolds lost more than half of their strength and rigidity. On the contrary, the densification modulus of the PLLA based blends increased with degradation time, whereas PCL-based blends had a relatively constant densification modulus. PCL-based samples showed lower hydrolysis coefficients k than PLLA-based samples, as expected from the higher density of ester bonds in the latter. Interestingly, although including HAp leads to a lower hydrolysis coefficient k in PCL rich samples, it increases k in the PLLA-based sample, which is consistent with the other results obtained.The authors are grateful for the support of the Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine, an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, and Consolider Program. J. Rodenas-Rochina acknowledges the funding of his PhD by the Valencian Generality through VALi+d grant.Ródenas Rochina, J.; Vidaurre, A.; Castilla Cortázar, MIC.; Lebourg ., MM. (2015). Effects of hydroxyapatite filler on long-term hydrolytic degradation of PLLA/PCL. Polymer Degradation and Stability. 119:121-131. doi:10.1016/j.polymdegradstab.2015.04.01512113111

Strategic Crop and Greenhouse Management in Mild Winter Climate Areas

In the last decades, the increase of protected cultivation in glasshouses has been very scarce as compared with the large spread of low-cost plastic greenhouses around the world. The greenhouse area in northern Europe has been almost stable, while protected cultivation expanded enormously in the Mediterranean basin, enhanced by the enlarging demand of vegetables for the export and domestic markets, resulting from economic development. In the past, the production strategies in the Mediterranean greenhouse industries have been mainly related with the adaptation of the crops to a suboptimal environment, due to the limited greenhouse climate control. There is now a general trend to better equipped greenhouses with improved climate management, in order to increase product quality. Achieving an economic compromise between the higher costs of improved greenhouses and their increased agronomic production are requiring different solutions, according to the local technical and socio-economic conditions, in order to produce proper quality commodities at competitive levels, relative to the higher performances of the sophisticated glasshouse industry of northern European countries. The distance from the European markets, in export focused production, increases the transportation cost of Mediterranean production, limiting its competitiveness. The rise of the technological level in the “Mediterranean greenhouse agrosystem” includes diverse improvements related with greenhouse design and climate management, crop techniques and practices (cultivars, cycles, plant protection, irrigation, substrates,...) and market-oriented production strategies in the various conditions of the Mediterranean basin. The cultural level of the growers in different countries can be a limiting factor to improving the technological level of the greenhouses, and great efforts are being made to transfer this knowledge to the growers, providing them with the methodology of optimization of their production systems

Soncillo (Burgos) : aula activa de la naturaleza

Copia digital : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

Un maestro de la dermatología española: José Eugenio de Olavide

Este interesante estudio sobre la vida y obra de José Eugenio de Olavide y Landazábal, uno de los dermatólogos españoles más reputados del siglo XIX, autor del Atlas de la Clínica Iconográfica de Enfermedades de la Piel o Dermatosis(1873), entre otras obras, permite a los autores realizar un pormenorizado análisis comparativo entre los tratamientos decimonónicos y los actuales con los que la dermatología ha enfrentado y enfrenta, las enfermedades de la piel. La revisión cuidadosa de la vida y la obra de José Eugenio de Olavide supone profundizar en el conocimiento de esta rama de la medicina y en el de los hombres que la han hecho posible

Row covers for quality improvement of Chinese cabbage (Brassica rapa subsp. Pekinensis)

Row covers of polypropylene sheeting have been studied in relation to the quality in Chinese cabbage (Brassica rapa subsp. Pekinensis ’Nagaoka 50') for 3 years (1999, 2000, and 2001) in the area of Granada, Spain, under a Mediterranean continental temperate climate, on 55‐day cycles with transplanting in mid March. The mean commercial yield for the 3 years was 11.9 kg m–2 under row covers, but only 2.1 kg m–2 in open air, owing primarily to the important number of non‐commercial cabbages. The cabbages grown in the open air were exposed to lower temperatures than under covers and showed a higher number of plants with bolting and plants lost in the field. The better thermal regime under the covers and the least vapour pressure deficit favoured heading, reducing the number of malformed cabbages. The foliar calcium (Ca) content in the outer leaves was significantly greater in the open air than under the row cover, whereas the reverse was true in the inner leaves. These lower Ca contents in the inner leaves of the open air plants, encouraged tipburn. The use of the row cover constitutes a low‐cost technique to improve open air spring cultivation of this leafy vegetable in this type of Mediterranean continental climate