Inclusion of Students with High Need Autism: General education teachers’ attitudes and beliefs versus practice

Given the simultaneous rise in rates of autism and the expectations for school-based inclusion of students with disabilities, research targeting inclusive practices continues to be a priority. Researchers have examined the attitudes and perspectives of general education teachers and best practice for including individuals with high functioning autism spectrum disorders. However, there is little research exploring the relationship between attitudes and practice with regard to the inclusion of individuals on the low functioning end of the spectrum. The purpose of this study was to explore the self-reported attitudes and perspectives of general education teachers in relation to what was observed and practiced in their general education classrooms when including a student with high need autism (HNA). The researcher conducted a pre- and post- self-reported attitudinal survey exploring beliefs about inclusion of students with disabilities in general and later the same survey asking specifically about inclusion of students with HNA. There was very little difference in the results from the two surveys. In general, teachers reported that they were willing to support inclusive practices and generally viewed inclusion as a positive experience. Twelve classroom observations of the general education teachers, the student with HNA and a typically developing comparison peer were completed (two per target student). Results reveal HNA students were actively engaged less than comparison peers (16% vs 28%). A greater disparity occurred for passive engagement, 16% for the student with HNA and 49% for the comparison student. When looking at off-task behavior, HNA students were off-task at a far higher rate than comparison students, primarily demonstrating off-task with a motor response. The rate of interaction between the general education teacher and the student with HNA was three times lower than the rate of interaction with the typically developing comparison peer. There was very little interaction between the targeted HNA student and any classroom peers. The findings implicate that general education teachers reported positive attitudes toward inclusion and demonstrated structural and environmental best practices in their classrooms. The findings also show that there appeared to be a lack of meaningful inclusive education opportunities for HNA students and the author calls for further research exploring how to optimize the value of time spent in the inclusive classroom

Faculty moonlighting: An exploratory study of the motivation for seeking outside employment and its relationship to the effectiveness of community college faculty

Full-time community college faculty moonlight to a much greater extent than does the general workforce. The number of faculty who work second jobs outside of their full-time teaching contract can be projected to exceed 40 percent with a strong possibility that more than half have employment outside of their primary faculty jobs. Chief community college administrators do not believe--or are not willing to admit--that their full-time faculty are so engaged in outside employment.;When faced with years of the same teaching assignments, heavy teaching and advising workloads but limited opportunities and resources for professional growth and renewal, veteran community college faculty become weary and unchallenged. They turn outside of their institutions to revitalize their career plateaus. When institutions fail to recognize or know how faculty respond when they feel stuck in their jobs, they jeopardize their greatest resource. Once lost to outside employment ventures, faculty become institutionally disengaged

Multi-Stakeholder Dispute Resolution: Building Social Capital Through Access to Justice at the Community Level

Systems of multi-stakeholder dispute resolution are increasingly recognized as objectives of good governance by international organizations such as the United Nations Development Program (UNDP). Such objectives arise out of insights based on the dynamics of social capital that community based initiatives cannot succeed where trust is absent and mechanisms for collective decision-making do not exist. Yet localized decision-making can take many forms-whether distributional, competitive, or collaborative. This paper will examine, in particular, the impact of collaborative systems of decision-making on building social capital through access to justice in local communities. It will do this through examining participant feedback, meeting minutes, and post-consultation reports of a community multi-stakeholder dialogue process in Cajamarca, Peru. The creation of dispute resolution forums where community members can actively participate in the generation of shared objectives, collect and access information, and take action on issues of collective concern represents an important foundation for the development of social capital

Population Control Policy: History, Ethics, and Global Implementation

This course enables students to identify how demographic transition and economic development are related to population trends, compare and contrast population control policies in modern-day Asian, African, North and South American countries, explore the relationship between human population and the environment, discuss ethical considerations of controlling population from a human rights perspective, and understand current trends in family planning. The presentation submitted with this course should be used for the September 23rd lecture on China's Approach to Population Control.Master of Public Healt

What are the ‘active ingredients’ of interventions targeting the public's engagement with antimicrobial resistance and how might they work?

Objectives. Changing public awareness of antimicrobial resistance (AMR) represents a global public health priority. A systematic review of interventions that targeted public AMR awareness and associated behaviour was previously conducted. Here, we focus on identifying the active content of these interventions and explore potential mechanisms of action. Methods. The project took a novel approach to intervention mapping utilizing the following steps: (1) an exploration of explicit and tacit theory and theoretical constructs within the interventions using the Theoretical Domains Framework (TDFv2), (2) retrospective coding of behaviour change techniques (BCTs) using the BCT Taxonomy v1, and (3) an investigation of coherent links between the TDF domains and BCTs across the interventions. Results. Of 20 studies included, only four reported an explicit theoretical basis to their intervention. However, TDF analysis revealed that nine of the 14 TDF domains were utilized, most commonly ‘Knowledge’ and ‘Environmental context and resources’. The BCT analysis showed that all interventions contained at least one BCT, and 14 of 93 (15%) BCTs were coded, most commonly ‘Information about health consequences’, ‘Credible source’, and ‘Instruction on how to perform the behaviour’. Conclusions. We identified nine relevant TDF domains and 14 BCTs used in these interventions. Only 15% of BCTs have been applied in AMR interventions thus providing a clear opportunity for the development of novel interventions in this context. This methodological approach provides a useful way of retrospectively mapping theoretical constructs and BCTs when reviewing studies that provide limited information on theory and intervention content

α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein

Journal ArticleThis is the author accepted manuscript. The final version is available from ASBMB via the DOI in this record.α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent. In vitro, its free radical-scavenging antioxidant action has been widely demonstrated. In vivo, however, vitamin E treatment exhibits negligible benefits against oxidative stress. α-Tocopherol influences lipid ordering within biological membranes and its derivatives have been suggested to inhibit the multi-drug efflux pump, P-glycoprotein (P-gp). This study employs the fluorescent membrane probe, 1-(3-sulfonatopropyl)-4-[β[2-(di-n-octylamino)-6-naphthyl]vinyl] pyridinium betaine, to investigate whether these effects are connected via influences on the membrane dipole potential (MDP), an intrinsic property of biological membranes previously demonstrated to modulate P-gp activity. α-Tocopherol and its non-free radical-scavenging succinate analog induced similar decreases in the MDP of phosphatidylcholine vesicles. α-Tocopherol succinate also reduced the MDP of T-lymphocytes, subsequently decreasing the binding affinity of saquinavir for P-gp. Additionally, α-tocopherol succinate demonstrated a preference for cholesterol-treated (membrane microdomain enriched) cells over membrane cholesterol-depleted cells. Microdomain disruption via cholesterol depletion decreased saquinavir's affinity for P-gp, potentially implicating these structures in the influence of α-tocopherol succinate on P-gp. This study provides evidence of a microdomain dipole potential-dependent mechanism by which α-tocopherol analogs influence P-gp activity. These findings have implications for the use of α-tocopherol derivatives for drug delivery across biological barriers

Cognitive Apprenticeship and the Supervision of Science and Engineering Research Assistants

We explore and critically reflect on the process of science and engineering research assistant skill development both within laboratory-based research teams and, when no team is present, within the faculty supervisor-research assistant interactions. Using a performance-based measure of research skill development, we identify research assistants who, over the course of an academic year of service as a researcher, markedly developed, modestly developed, or failed to develop their research skills. Interviews with these research assistants and their faculty supervisors, seen through the lens of cognitive apprenticeship, provide insight into this variation. We found that within the contours of supervisory relationships and research teams, research skill development is indelibly shaped, for better or worse, by supervisor influence and abundant trial-and-error

Location-specific cutaneous electrical stimulation of the footsole modulates corticospinal excitability to the plantarflexors and dorsiflexors during standing

Non-noxious electrical stimulation to distinct locations of the foot sole evokes location-specific cutaneous reflex responses in lower limb muscles. These reflexes occur at latencies that may enable them to be mediated via a transcortical pathway. Corticospinal excitability to the plantarflexors and dorsiflexors was measured in 16 participants using motor evoked potentials (MEPs). Spinal excitability was measured in eight of the original participants using cervicomedullary motor evoked potentials (CMEPs). Measurements were collected with and without preceding cutaneous stimulus to either the heel (HEEL) or metatarsal (MET) locations of the foot sole, and evoked potentials were elicited to coincide with the arrival of the cutaneous volley at either the motor cortex or spinal cord. Plantarflexor MEPs and CMEPs were facilitated with cutaneous stimulation to the HEEL for MEPs (soleus p = 0.04, medial gastrocnemius (MG) p = 0.017) and CMEPs (soleus p = 0.047 and MG p = 0.015), but they were unchanged following MET stimulation for MEPs or CMEPs. Dorsiflexor MEPs were unchanged with cutaneous stimulation at either location, but dorsiflexor CMEPs increased with cutaneous stimulation (p = 0.05). In general, the increase in CMEP amplitudes was larger than the increase in MEP amplitudes, indicating that an increase in spinal excitability likely explains most of the increase in corticospinal excitability. The larger change observed in the CMEP also indicates that excitability from supraspinal sources likely decreased, which could be due to a net change in the excitability of intracortical circuits. This study provides evidence that cutaneous reflexes from foot sole skin are likely influenced by a transcortical pathway

Dependence of Galaxy Quenching on Halo Mass and Distance from its Centre

We study the dependence of star-formation quenching on galaxy mass and environment, in the SDSS (z~0.1) and the AEGIS (z~1). It is crucial that we define quenching by low star-formation rate rather than by red colour, given that one third of the red galaxies are star forming. We address stellar mass M*, halo mass Mh, density over the nearest N neighbours deltaN, and distance to the halo centre D. The fraction of quenched galaxies appears more strongly correlated with Mh at fixed M* than with M* at fixed Mh, while for satellites quenching also depends on D. We present the M*-Mh relation for centrals at z~1. At z~1, the dependence of quenching on M* at fixed Mh is somewhat more pronounced than at z~0, but the quenched fraction is low (10%) and the haloes are less massive. For satellites, M*-dependent quenching is noticeable at high D, suggesting a quenching dependence on sub-halo mass for recently captured satellites. At small D, where satellites likely fell in more than a few Gyr ago, quenching strongly depends on Mh, and not on M*. The Mh-dependence of quenching is consistent with theoretical wisdom where virial shock heating in massive haloes shuts down accretion and triggers ram-pressure stripping, causing quenching. The interpretation of deltaN is complicated by the fact that it depends on the number of observed group members compared to N, motivating the use of D as a better measure of local environment.Comment: 23 pages, 13 figures, accepted by MNRA

Woody stem methane emission in mature wetland alder trees

Methane (CH4) is an important greenhouse gas that is predominantly emitted to the atmosphere from anoxic wetland ecosystems. Understanding the sources and emissions of CH4 is crucially important for climate change predictions; however, there are significant discrepancies between CH4 source estimates derived via so-called bottom-up and top-down methods. Here we report CH4 emission from the stems of mature wetland alder (Alnus glutinosa) trees in the UK, a common tree of northern hemisphere floodplains and wetlands. The alder stems most likely behave as conduits for soil-produced CH4 either in the gaseous or aqueous phase, and may, therefore, help to reconcile methodological differences in the way the wetland CH4 source is estimated. Alder tree stems emitted average peak CH4 fluxes of 101 μg CH4 m−2 h−1 (on a stem area basis) in early October, a rate that is similar to that obtained from mature Japanese ash (Fraxinus mandshurica var. japonica) in Japan and amounting to approximately 20% of the measured CH4 flux from the soil surface. The finding suggests that trees, which occupy 60% of Earth's wetlands and are normally excluded from the measurement programmes that form the basis for bottom-up estimates of the global wetland source, could be important contributors to overall terrestrial ecosystem CH4 flux