Association between Cardio-Ankle Vascular Index and Masked Uncontrolled Hypertension in Hypertensive Patients: A Cross-Sectional Study

Detection of masked uncontrolled hypertension (MUCH) that was defined for treated hypertensive individuals who had normal office blood pressure (BP) but elevated ambulatory BP remains largely challenging. Arterial stiffness is one of the leading risk markers for hypertension and can be clinically assessed by the cardio-ankle vascular index (CAVI). This study aimed to evaluate the association between CAVI and MUCH. A total of 155 hypertensive patients were included with their office BP levels and ambulatory BP monitoring measurements, which were divided into controlled hypertension (CH), MUCH, and sustained uncontrolled hypertension (SUCH) groups, respectively. There were 48 patients with CH, 56 patients with MUCH, and 51 patients with SUCH. Both MUCH and SUCH groups had a significantly higher CAVI than the CH group (9.05 (8.20–9.91) vs. 8.33 (7.75–9.15), p=0.017, and 9.75 (8.35–10.50) vs. 8.33 (7.75–9.15), p=0.002, respectively). There was no significant difference in CAVI values between the MUCH and SUCH groups. Multinomial logistic regression analysis exhibited that compared with the CH group, increased CAVI levels were positively associated with the presence of MUCH and SUCH (OR 2.046, 95% CI (1.239–3.381), p=0.005; OR 2.215, 95% CI (1.310–3.747), p=0.003) after adjusting for confounders. However, there was a similar trend of the CAVI in the MUCH and SUCH groups (OR 0.924, 95% CI (0.629–1.356), p=0.686). In summary, our findings support, for the first time, the novel notion that CAVI as an arterial stiffness parameter is an independent risk factor for MUCH, being equally important to MUCH and SUCH. When the assessed CAVI is high in hypertensive patients with normotensive office BP levels, it is necessary to further investigate with a 24 h ambulatory BP monitoring to estimate the longstanding BP control. CAVI may be used as a noninvasive indicator to identify patients with MUCH earlier

BEAM EXTRACTION SYSTEM DESIGN FOR CYCIAE-14

Abstract A 14MeV medical cyclotron is under design and construction at CIAE (China Institute of Atomic Energy). H -ion will be accelerated in this cyclotron and proton beam will be extracted by carbon strippers in dual opposite direction. Two stripping points are chosen in each extracting direction to extract proton beams to different targets to extend the use of the machine and the stripping points can be selected only by rotating the stripping foil. Two modes have been considered of the extraction system, one is designed to be installed on the wall of the vacuum chamber, the other is designed to be inserted vertically from the sector poles. Final choice will depend on the agility, the simpleness and the results of the experimentation. The angle between the stripper and the beam orbit is optimized to improve the extracted beam quality. Numerical simulation shows the two stripping points, the beam orbit and the beam characteristic at each extraction direction. The optimized azimuth of the stripper is also presented in this paper to show its influence for the beam quality. Based on the concept design, the mechanical design and the correlative experimentation have been done; the results are shown in the paper. PACS: 29.20.HM CYCLOTRON

BEAM EXTRACTION SYSTEM DESIGN FOR CYCIAE-14

construction at CIAE (China Institute of Atomic Energy).<br />H- ion will be accelerated in this cyclotron and proton<br />beam will be extracted by carbon strippers in dual<br />opposite direction. Two stripping points are chosen in<br />each extracting direction to extract proton beams to<br />different targets to extend the use of the machine and the<br />stripping points can be selected only by rotating the<br />stripping foil. Two modes have been considered of the<br />extraction system, one is designed to be installed on the<br />wall of the vacuum chamber, the other is designed to be<br />inserted vertically from the sector poles. Final choice will<br />depend on the agility, the simpleness and the results of the<br />experimentation. The angle between the stripper and the<br />beam orbit is optimized to improve the extracted beam<br />quality. Numerical simulation shows the two stripping<br />points, the beam orbit and the beam characteristic at each<br />extraction direction. The optimized azimuth of the<br />stripper is also presented in this paper to show its<br />influence for the beam quality. Based on the concept<br />design, the mechanical design and the correlative<br />experimentation have been done; the results are shown in<br />the paper.IMP;Chinese Academy of Science

p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension

Aim. Hypertension is a complicated disorder with multifactorial etiology and high heritability. Our previous work has identified L3MBTL4 as a novel susceptibility gene for the development of essential hypertension, accompanied with activation of p38/JNK. Yet, little evidence has been reported whether p38/JNK contributed directly to L3MBTL4-induced vascular remodeling and exploring the potential mechanism of L3MBTL4 in vascular smooth muscle cells (VSMCs). Methods. We evaluated the contribution of L3MBTL4 on proliferation, migration, and phenotype changes of VSMCs and further explored the critical role of p38 and JNK signaling pathway underlying. Results. In L3MBTL4 transgenic rats, we found that the elevated blood pressure, increased left ventricular hypertrophy, and thickened vascular media layer were significantly relieved by both p38 and JNK inhibitors. Meanwhile, increased cell proliferation, advanced cell cycle progression, greater migratory capability, and synthetic phenotype were observed in L3MBTL4 overexpressed VSMCs, which could be blocked by either p38 or JNK inhibitor. Conclusions. Our findings pinpointed that p38 and JNK were required for the proliferation and phenotype changes of VSMCs induced by L3MBTL4 in hypertension. These novel findings yield new insights into the genetic and biological basis of hypertension and are fundamental for further studies to explore the intervention strategies targeting L3MBTL4 and p38/JNK to counteract the progression of hypertension

Practice and innovation in the operation and maintenance of HI-13 tandem accelerator for 35 years

The HI-13 tandem accelerator, located at the Beijing Tandem Accelerator National Laboratory, has been in operation for 35 years. To ensure the continued performance of the accelerator, the operation and maintenance team has prioritized focus on various aspects. The operation team conducted research that involved developing key components, cultivating a high-quality operational team, improving the machine time efficiency, and increasing the participation of users outside the China Institute of Atomic Energy (CIAE). The primary emphasis has been on developing key components and upgrading subsystems. These efforts have successfully maintained and improved the accelerator's performance, ensuring its safe and stable operation. Finally, the paper alse discusses the challenges faced by tandem accelerators and presents future development plans

Progress of Jinping Underground laboratory for Nuclear Astrophysics (JUNA)

Jinping Underground lab for Nuclear Astrophysics (JUNA) will take the advantage of the ultralow background in Jinping underground lab, high current accelerator based on an ECR source and highly sensitive detector to study directly a number of crucial reactions to the hydrostatic stellar evolution for the first time at their relevant stellar energies. In its first phase, JUNA aims at the direct measurements of 25Mg(p,γ)26Al, 19F(p,α)16O, 13C(α,n)16O and 12C(α,γ)16O. The experimental setup, which include the accelerator system with high stability and high intensity, the detector system, and the shielding material with low background, will be established during the above research. The current progress of JUNA will be given

Progress of Jinping Underground laboratory for Nuclear Astrophysics (JUNA)

Jinping Underground lab for Nuclear Astrophysics (JUNA) will take the advantage of the ultralow background in Jinping underground lab, high current accelerator based on an ECR source and highly sensitive detector to study directly a number of crucial reactions to the hydrostatic stellar evolution for the first time at their relevant stellar energies. In its first phase, JUNA aims at the direct measurements of 25Mg(p,γ)26Al, 19F(p,α)16O, 13C(α,n)16O and 12C(α,γ)16O. The experimental setup, which include the accelerator system with high stability and high intensity, the detector system, and the shielding material with low background, will be established during the above research. The current progress of JUNA will be given

Commissioning of Underground Nuclear Astrophysics Experiment JUNA in China

Underground Nuclear Astrophysics Experiment in China (JUNA) has been commissioned by taking the advantage of the ultra-low background in Jinping underground lab. High current mA level 400 KV accelerator with an ECR source and BGO detectors were commissioned. JUNA studies directly a number of nuclear reactions important to hydrostatic stellar evolution at their relevant stellar energies. In the first quarter of 2021, JUNA performed the direct measurements of 25Mg(p,γ)26Al, 19F(p,α)16O, 13C(α,n)16O and 12C(α,γ)16O near the Gamow window. The experimental results reflect the potential of JUNA with higher statistics, precision and sensitivity of the data. The preliminary results of JUNA experiment and future plan are given