Kras Mutation Statistics.

<p>Kras Mutation Statistics.</p

High Content Analysis of BAX expression in three cell lines.

<p>Propofol treatment increased the BAX expression in A549 cells treated for 6 hours with 25 µM of propofol. No change in BAX expression in all other groups and other two cell lines. (A) High content analysis of expression BAX in A549 cell treated with 25 µM of propofol for 6 hour. Nuclei were stained blue. BAX positive cells were stained green. Images were acquired at 5× magnification lens. (a) A549 cell treated with 0.5% DMSO for 6 hours. (b) A549 treated with 25 µM of propofol made with 0.5% DMSO for 6 hours. These results are representative of three independent experiments. (B) Charts indicate BAX expression in A549 (a), LoVo (b), and SKBR3 (c) lines with the induction of propofol for 6 hours. There is no BAX signal change after 24 hour treatment with all three concentrations of propofol for any of the three lines tested here. Each value was determined with Target Activation BioApplication Guide suggested by manufacturer (Thermo Scientific), and normalized to the expression of BAX with 0.5% DMSO incubation, and represents a mean of triplicate determinants. The results were evaluated by ANOVA test. A star () indicates statistically significant difference with the P<0.05.</p

Propofol treatment decreased ERK1/2 activation in A549 cells.

<p>(A) The Western Blot Image of time course of Phosphorylated ERK1/2 Expression in A549 Treated with 100 µM propofol. (B) The Quantification of the Western Blot. These results are representative of three independent experiments with a total of 15 samples. By using One Way ANOVA testing, we found the differences from all one-hour propofol groups to be significantly lower compared with the 0-hour group with a P value <0.0001. ANOVA was used to do the analysis.</p

Results of Propofol Induced Apoptosis in Cancer Cells with Different Kras Gene Types.

<p>Results of Propofol Induced Apoptosis in Cancer Cells with Different Kras Gene Types.</p

Replace the fixed effect models and data.

In a dynamic and competitive business environment, managerial ability emerges as a pivotal strategic factor for capitalizing on new opportunities within the technological revolution and digital transformation of enterprises. Based on data from Chinese A-share listed firms spanning from 2009 to 2019, this study integrates insights from the upper echelons theory and the behavioral theory of the firm to investigate the moderating roles of historical aspiration shortfalls and industrial competitiveness on the relationship between managerial ability and enterprise digital transformation from internal and external pressure perspectives. Our findings indicate a positive impact of managerial ability on digital transformation. The relationship between managerial ability and digital transformation is reinforced by historical aspiration shortfalls; nevertheless, industrial competitiveness has attenuated the aforementioned relationship. This study contributes to a better understanding of the strategic implications of managerial ability within the context of organizational innovation strategies. It offers valuable insights into the decision-making processes of firms as they navigate the challenges of digital transformation within an ever-evolving business environment.</div

The test of mediating effects based on equity incentive mechanism.

The test of mediating effects based on equity incentive mechanism.</p

Fig 1 -

In a dynamic and competitive business environment, managerial ability emerges as a pivotal strategic factor for capitalizing on new opportunities within the technological revolution and digital transformation of enterprises. Based on data from Chinese A-share listed firms spanning from 2009 to 2019, this study integrates insights from the upper echelons theory and the behavioral theory of the firm to investigate the moderating roles of historical aspiration shortfalls and industrial competitiveness on the relationship between managerial ability and enterprise digital transformation from internal and external pressure perspectives. Our findings indicate a positive impact of managerial ability on digital transformation. The relationship between managerial ability and digital transformation is reinforced by historical aspiration shortfalls; nevertheless, industrial competitiveness has attenuated the aforementioned relationship. This study contributes to a better understanding of the strategic implications of managerial ability within the context of organizational innovation strategies. It offers valuable insights into the decision-making processes of firms as they navigate the challenges of digital transformation within an ever-evolving business environment.</div

Fig 2 -

In a dynamic and competitive business environment, managerial ability emerges as a pivotal strategic factor for capitalizing on new opportunities within the technological revolution and digital transformation of enterprises. Based on data from Chinese A-share listed firms spanning from 2009 to 2019, this study integrates insights from the upper echelons theory and the behavioral theory of the firm to investigate the moderating roles of historical aspiration shortfalls and industrial competitiveness on the relationship between managerial ability and enterprise digital transformation from internal and external pressure perspectives. Our findings indicate a positive impact of managerial ability on digital transformation. The relationship between managerial ability and digital transformation is reinforced by historical aspiration shortfalls; nevertheless, industrial competitiveness has attenuated the aforementioned relationship. This study contributes to a better understanding of the strategic implications of managerial ability within the context of organizational innovation strategies. It offers valuable insights into the decision-making processes of firms as they navigate the challenges of digital transformation within an ever-evolving business environment.</div

Descriptive summary.

In a dynamic and competitive business environment, managerial ability emerges as a pivotal strategic factor for capitalizing on new opportunities within the technological revolution and digital transformation of enterprises. Based on data from Chinese A-share listed firms spanning from 2009 to 2019, this study integrates insights from the upper echelons theory and the behavioral theory of the firm to investigate the moderating roles of historical aspiration shortfalls and industrial competitiveness on the relationship between managerial ability and enterprise digital transformation from internal and external pressure perspectives. Our findings indicate a positive impact of managerial ability on digital transformation. The relationship between managerial ability and digital transformation is reinforced by historical aspiration shortfalls; nevertheless, industrial competitiveness has attenuated the aforementioned relationship. This study contributes to a better understanding of the strategic implications of managerial ability within the context of organizational innovation strategies. It offers valuable insights into the decision-making processes of firms as they navigate the challenges of digital transformation within an ever-evolving business environment.</div

Fig 3 -

In a dynamic and competitive business environment, managerial ability emerges as a pivotal strategic factor for capitalizing on new opportunities within the technological revolution and digital transformation of enterprises. Based on data from Chinese A-share listed firms spanning from 2009 to 2019, this study integrates insights from the upper echelons theory and the behavioral theory of the firm to investigate the moderating roles of historical aspiration shortfalls and industrial competitiveness on the relationship between managerial ability and enterprise digital transformation from internal and external pressure perspectives. Our findings indicate a positive impact of managerial ability on digital transformation. The relationship between managerial ability and digital transformation is reinforced by historical aspiration shortfalls; nevertheless, industrial competitiveness has attenuated the aforementioned relationship. This study contributes to a better understanding of the strategic implications of managerial ability within the context of organizational innovation strategies. It offers valuable insights into the decision-making processes of firms as they navigate the challenges of digital transformation within an ever-evolving business environment.</div