981 research outputs found
Two newly recorded species of the genus Herpetogramma (Lepidoptera: Crambidae: Spilomelinae) in Korea
AbstractTwo species of the genus Herpetogramma Lederer are reported for the first time in Korea: Herpetogramma licarsisalis (Walker) and Herpetogramma stultalis (Walker). The description, host plants, adult photographs, and pictures of the male and female genitalia are provided
Mathematical modeling of simultaneous carbon-nitrogen-sulfur removal from industrial wastewater
A mathematical model of carbon, nitrogen and sulfur removal (C-N-S) from industrial wastewater was constructed considering the interactions of sulfate-reducing bacteria (SRB), sulfide-oxidizing bacteria (SOB), nitrate-reducing bacteria (NRB), facultative bacteria (FB), and methane producing archaea (MPA). For the kinetic network, the bioconversion of C-N by heterotrophic denitrifiers (NO\ua0→\ua0NO\ua0→\ua0N), and that of C-S by SRB (SO\ua0→\ua0S) and SOB (S\ua0→\ua0S) was proposed and calibrated based on batch experimental data. The model closely predicted the profiles of nitrate, nitrite, sulfate, sulfide, lactate, acetate, methane and oxygen under both anaerobic and micro-aerobic conditions. The best-fit kinetic parameters had small 95% confidence regions with mean values approximately at the center. The model was further validated using independent data sets generated under different operating conditions. This work was the first successful mathematical modeling of simultaneous C-N-S removal from industrial wastewater and more importantly, the proposed model was proven feasible to simulate other relevant processes, such as sulfate-reducing, sulfide-oxidizing process (SR-SO) and denitrifying sulfide removal (DSR) process. The model developed is expected to enhance our ability to predict the treatment of carbon-nitrogen-sulfur contaminated industrial wastewater
TMRT observations of 26 pulsars at 8.6 GHz
Integrated pulse profiles at 8.6~GHz obtained with the Shanghai Tian Ma Radio
Telescope (TMRT) are presented for a sample of 26 pulsars. Mean flux densities
and pulse width parameters of these pulsars are estimated. For eleven pulsars
these are the first high-frequency observations and for a further four, our
observations have a better signal-to-noise ratio than previous observations.
For one (PSR J0742-2822) the 8.6~GHz profiles differs from previously observed
profiles. A comparison of 19 profiles with those at other frequencies shows
that in nine cases the separation between the outmost leading and trailing
components decreases with frequency, roughly in agreement with
radius-to-frequency mapping, whereas in the other ten the separation is nearly
constant. Different spectral indices of profile components lead to the
variation of integrated pulse profile shapes with frequency. In seven pulsars
with multi-component profiles, the spectral indices of the central components
are steeper than those of the outer components. For the 12 pulsars with
multi-component profiles in the high-frequency sample, we estimate the core
width using gaussian fitting and discuss the width-period relationship.Comment: 33 pages, 49 figures, 5 Tables; accepted by Ap
PRL-3, a Metastasis Associated Tyrosine Phosphatase, Is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy
Combination with other small molecule drugs represents a promising strategy to improve therapeutic efficacy of FLT3 inhibitors in the clinic. We demonstrated that combining ABT-869, a FLT3 inhibitor, with SAHA, a HDAC inhibitor, led to synergistic killing of the AML cells with FLT3 mutations and suppression of colony formation. We identified a core gene signature that is uniquely induced by the combination treatment in 2 different leukemia cell lines. Among these, we showed that downregulation of PTP4A3 (PRL-3) played a role in this synergism. PRL-3 is downstream of FLT3 signaling and ectopic expression of PRL-3 conferred therapeutic resistance through upregulation of STAT (signal transducers and activators of transcription) pathway activity and anti-apoptotic Mcl-1 protein. PRL-3 interacts with HDAC4 and SAHA downregulates PRL-3 via a proteasome dependent pathway. In addition, PRL-3 protein was identified in 47% of AML cases, but was absent in myeloid cells in normal bone marrows. Our results suggest such combination therapies may significantly improve the therapeutic efficacy of FLT3 inhibitors. PRL-3 plays a potential pathological role in AML and it might be a useful therapeutic target in AML, and warrant clinical investigation
GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis
Gene Ontology (GO) analysis has become a commonly used approach for functional studies of large-scale genomic or transcriptomic data. Although there have been a lot of software with GO-related analysis functions, new tools are still needed to meet the requirements for data generated by newly developed technologies or for advanced analysis purpose. Here, we present a Gene Ontology Enrichment Analysis Software Toolkit (GOEAST), an easy-to-use web-based toolkit that identifies statistically overrepresented GO terms within given gene sets. Compared with available GO analysis tools, GOEAST has the following improved features: (i) GOEAST displays enriched GO terms in graphical format according to their relationships in the hierarchical tree of each GO category (biological process, molecular function and cellular component), therefore, provides better understanding of the correlations among enriched GO terms; (ii) GOEAST supports analysis for data from various sources (probe or probe set IDs of Affymetrix, Illumina, Agilent or customized microarrays, as well as different gene identifiers) and multiple species (about 60 prokaryote and eukaryote species); (iii) One unique feature of GOEAST is to allow cross comparison of the GO enrichment status of multiple experiments to identify functional correlations among them. GOEAST also provides rigorous statistical tests to enhance the reliability of analysis results. GOEAST is freely accessible at http://omicslab.genetics.ac.cn/GOEAST
Low divergence single-mode surface-emitting concentric-circular-grating terahertz quantum cascade lasers
We report the design, fabrication and experimental characterization of surface-emitting terahertz (THz) frequency quantum cascade lasers (QCLs) with distributed feedback concentric-circular-gratings. Single-mode operation is achieved at 3.73 THz with a side-mode suppression ratio as high as ~30 dB. The device emits ~5 times the power of a ridge laser of similar dimensions, with little degradation in the maximum operation temperature. Two lobes are observed in the far-field emission pattern, each of which has a divergence angle as narrow as ~13.5° × 7°. We demonstrate that deformation of the device boundary, caused by anisotropic wet chemical etching is the cause of this double-lobed profile, rather than the expected ring-shaped pattern
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