Geometry of Punctured Riemann Surfaces Moduli

In this thesis, we study the geometry of Teichmuller space of punctured Riemann surfaces.We use L2 Hodge theory to describe the deformation theory for punctured Riemann surfaces,in which we defined Weil-Petersson metric, Hodge metric and Kodaira-Spencer map. Wealso give a new proof of Wolpert's curvature formula by computing the expansion of volumeform and the Kodaira-Spencer map. We use Wolpert's formula to estimate upper bound forvarious curvature tensor. We construct an extension of pluricanonical form and compare itto the expansion of the Kodaira-Spencer map under Hodge metric

A Report on an Internship with the Wall Street Zhongwen

The following internship report is based on my experience as administrative assistant to the Principal of Wall Street Zhongwen (hereinafter referred to as “WSZ”) during the spring semester of 2013. Wall Street Zhongwen is a Chinese-language school with a multifaceted mission and staff. It is based in the Financial District of New York City in the heart of Wall Street culture. I will focus on a critical, descriptive analysis of the organization with a S.W.O.T analysis, best practices of educational institutions comparisons, and recommendations for the development of Wall Street Zhongwen

Comparison of Body Measuring Techniques: Whole Body Scanner, Handheld Scanner, and Tape Measure

Whole body scanners and manual measuring techniques are used in the apparel industry to collect body measurement data. Researchers have been seeking alternatives due to the high cost of the whole body scanner and labor intensiveness of the manual measuring method. Handheld scanners have been studied recently as replacements of other methods, but most of the results were unsatisfactory. The Structure Sensor is a handheld scanner developed by Occipital and has been branded as the first 3D sensor for mobile devices such as iPhone and iPad. This research focused on comparing the performance of the Structure Sensor to other techniques to see whether it could be used as a substitute for them or not. Measurements were collected and compared. It was found that the Structure Sensor could be used to collect body measurements data with low accuracy if corresponding measurement extraction software was developed

How cognitive and reactive fear circuits optimize escape decisions in humans

Flight initiation distance (FID), the distance at which an organism flees from an approaching threat, is an ecological metric of cost–benefit functions of escape decisions. We adapted the FID paradigm to investigate how fast- or slow-attacking “virtual predators” constrain escape decisions. We show that rapid escape decisions rely on “reactive fear” circuits in the periaqueductal gray and midcingulate cortex (MCC), while protracted escape decisions, defined by larger buffer zones, were associated with “cognitive fear” circuits, which include posterior cingulate cortex, hippocampus, and the ventromedial prefrontal cortex, circuits implicated in more complex information processing, cognitive avoidance strategies, and behavioral flexibility. Using a Bayesian decision-making model, we further show that optimization of escape decisions under rapid flight were localized to the MCC, a region involved in adaptive motor control, while the hippocampus is implicated in optimizing decisions that update and control slower escape initiation. These results demonstrate an unexplored link between defensive survival circuits and their role in adaptive escape decisions

Probing Higgs CPCP properties at the CEPC

In the Circular Electron Positron Collider (CEPC), a measurement of the Higgs $CP$ mixing through $e^{+} e^{-} \rightarrow Z H \rightarrow \mu^{+} \mu^{-} H(\rightarrow b \bar{b} / c \bar{c} / g g)$ process is presented, with $5.6\ \mbox{ab}^{-1}$$e^{+} e^{-}$collision data at the center-of-mass energy of$240\ \mathrm{GeV}$. In this study, the$CP$-violating parameter$\hat{\alpha}_{A \tilde{Z}}$is constrained between the region of$ -8.27\times 10^{-2}$and$8.09 \times 10^{-2}$and$\hat{\alpha}_{Z \tilde{Z}}$between$-2.15 \times 10^{-2}$and$2.02 \times 10^{-2}$at$95\%$confidence level. This study demonstrates the great potential of probing Higgs$CP$ properties at the CEPC

How cognitive and reactive fear circuits optimize escape decisions in humans

Flight initiation distance (FID), the distance at which an organism flees from an approaching threat, is an ecological metric of cost–benefit functions of escape decisions. We adapted the FID paradigm to investigate how fast- or slow-attacking “virtual predators” constrain escape decisions. We show that rapid escape decisions rely on “reactive fear” circuits in the periaqueductal gray and midcingulate cortex (MCC), while protracted escape decisions, defined by larger buffer zones, were associated with “cognitive fear” circuits, which include posterior cingulate cortex, hippocampus, and the ventromedial prefrontal cortex, circuits implicated in more complex information processing, cognitive avoidance strategies, and behavioral flexibility. Using a Bayesian decision-making model, we further show that optimization of escape decisions under rapid flight were localized to the MCC, a region involved in adaptive motor control, while the hippocampus is implicated in optimizing decisions that update and control slower escape initiation. These results demonstrate an unexplored link between defensive survival circuits and their role in adaptive escape decisions

FTO Knockout Causes Chromosome Instability and G2/M Arrest in Mouse GC-1 Cells

N6-methyladenosine (m6A) is the most abundant modification on eukaryotic mRNA. m6A plays important roles in the regulation of post-transcriptional RNA splicing, translation, and degradation. Increasing studies have uncovered the significance of m6A in various biological processes such as stem cell fate determination, carcinogenesis, adipogenesis, stress response, etc, which put forwards a novel conception called epitranscriptome. However, functions of the fat mass and obesity-associated protein (FTO), the first characterized m6A demethylase, in spermatogenesis remains obscure. Here we reported that depletion of FTO by CRISPR/Cas9 induces chromosome instability and G2/M arrest in mouse spermatogonia, which was partially rescued by expression of wild type FTO but not demethylase inactivated FTO. FTO depletion significantly decreased the expression of mitotic checkpoint complex and G2/M regulators. We further demonstrated that the m6A modification on Mad1, Mad2, Bub1b, Cdk1, and Ccnb2 were directly targeted by FTO. Therefore, FTO regulates cell cycle and mitosis checkpoint in spermatogonia because of its m6A demethylase activity. The findings give novel insights into the role of RNA methylation in spermatogenesis

Elevated Monocyte to High-density Lipoprotein Ratio Is a Risk Factor for New-onset Atrial Fibrillation after Off-pump Coronary Revascularization

Atrial fibrillation (AF) is a common complication of coronary revascularization. Currently, the mechanisms of postoperative AF are unclear. This study was aimed at investigating the risk factors for new-onset AF (NOAF) after coronary revascularization and exploring the early warning effects of clinical inflammatory markers. A retrospective analysis was conducted on 293 patients with unstable angina pectoris who underwent coronary artery revascularization in Beijing Chao-Yang Hospital, Capital Medical University, between April 2018 and June 2021, including 224 patients who underwent coronary artery bypass grafting and 69 patients who underwent one-step hybrid coronary revascularization. Baseline data, clinical data, blood indicators and AF episodes within 7 days after the surgery were collected. Participants were divided into two groups according to whether AF occurred, and the data were analyzed between groups. In addition, multivariate logistic regression was used to explore the independent risk factors for developing AF post coronary revascularization. Aging, a larger left atrial inferior-superior diameter, use of an intra-aortic balloon pump, a greater blood volume transfused during perioperative period and a higher monocyte to high-density lipoprotein ratios on postoperative day 1 were independent risk factors for NOAF after coronary artery surgery