Gene-environment interactions.

<p>^a major/minor allele</p><p>^b odds ratio</p><p>^c adjusted for age and gender</p><p>^d ≥ 17 pack years (median)</p><p>^e lifetime exposure to pesticide >26 days.</p><p>Gene-environment interactions.</p

Study demographics.

<p>^a Odds ratio (95% CI) calculated using binary logistic regression</p><p>^b Wilcoxon rank sum test</p><p>^c pack years equivalent to packs per day multiplied by years smoked</p><p>^d pack years dichotomised according to median <17 & ≥ 17 pack years (zero pack years removed)</p><p>^e Pesticide exposure is equivalent to exposure of herbicides, pesticides, or fungicides at least once weekly for a period of six months.</p><p>Study demographics.</p

Genotyping associations of SNPs and Parkinson’s disease.

<p>^a Major/minor allele</p><p>^b Odds ratio</p><p>^c adjusted for age and gender</p><p>^d Bonferroni corrected <i>P</i><0.05.</p><p>Genotyping associations of SNPs and Parkinson’s disease.</p

Haplotype construction map (VO1-VO7 & T1–T7) and associated AAO effects.

<p>NS = not significant (>0.05).</p

Haplotype frequencies and associations in PD cases and control.

<p>N/A = Data not provided</p><p>^a Bonferroni corrected <i>P</i> = 0.164</p><p>VO = ‘Von Otter Haplotype’ (rs10183914, rs2001350, rs1806649, rs2886161, rs7557529)</p><p>T = ‘Tagging Haplotype’ (rs13035806, rs2706110, rs10183914, rs2001350, rs6726395, rs1806649, rs2364722, rs2886161, rs2364725, rs7557529, rs1685105)</p><p>NS = not significant (>0.05).</p><p>Haplotype frequencies and associations in PD cases and control.</p