Security boundaries of an optical power limiter for protecting quantum key distribution systems

Unauthorized light injection has always been a vital threat to the practical security of a quantum key distribution (QKD) system. An optical power limiter (OPL) based on the thermo-optical defocusing effect has been proposed and implemented, limiting the injected hacking light. As a hardware countermeasure, the performance of the OPL under various light-injection attacks shall be tested to clarify the security boundary before being widely deployed. To investigate the OPL's security boundary in quantum cryptography, we comprehensively test and analyse the behavior of OPL under continuous-wave (c.w.) light-injection attacks and pulse illumination attacks with pulses' repetition rate at 0.5-Hz,40-MHz, and 1-GHz. The testing results illuminate the security boundary of the OPL, which allows one to properly employ the OPL in the use cases. The methodology of testing and analysis proposed here is applicable to other power-limitation components in a QKD system.Comment: 14 pages, 13 figure

On correlation between canopy vegetation and growth indexes of maize varieties with different nitrogen efficiencies

Studying the canopy spectral reflection characteristics of different N-efficient maize varieties and analyzing the relationship between their growth indicators and spectral vegetation indices can help the breeding and application of N-efficient maize varieties. To achieve the optimal management of N fertilizer resources, developing N-efficient maize varieties is necessary. In this research, maize varieties, i.e., the low-N-efficient (Zhengdan 958, ZD958), the high-N efficient (Xianyu 335, XY335), the double-high varieties (Qiule 368, QL368), and the double inefficient-type varieties (Yudan 606 YD606), were used as materials. Results indicate that nitrogen fertilization significantly increased the vegetation indices NDVI, GNDVI, GOSAVI, and RVI of maize varieties with different nitrogen efficiencies. These findings were consistent with the performance of yield, dry matter mass, and leaf nitrogen content and were also found highest under both medium and high nitrogen conditions in the double-high variety QL368. The correlations of dry matter quality, leaf nitrogen content, yield, and vegetation indices (NDVI, GNDVI, RVI, and GOSAVI) at the filling stage of different N-efficient maize varieties were all highly significant and positive. In this relationship, the best effect was found at the filling stages, with correlation coefficients reaching 0.772–0.942, 0.774–0.970, 0754–0.960, and 0.800–0.960. The results showed that the yield, dry matter weight, and leaf nitrogen content of maize varieties with different nitrogen efficiencies increased first and then stabilized with the increase in the nitrogen application level in different periods, and the highest nitrogen application level of maize yield should be between 270 and 360 kg/hm2. At the filling stage, canopy vegetation index of maize varieties with different nitrogen efficiencies was positively correlated with yield, dry matter weight, and leaf nitrogen content, especially GNDVI and GOSAVI on the leaf nitrogen content. It can be used as a means to predict its growth index

Evaluation of nanoparticle albumin-bound paclitaxel loaded macrophages for glioblastoma treatment based on a microfluidic chip

Introduction: Glioblastoma (GBM) is a primary brain malignancy with a dismal prognosis and remains incurable at present. In this study, macrophages (MΦ) were developed to carry nanoparticle albumin-bound paclitaxel (nab-PTX) to form nab-PTX/MΦ. The aim of this study is to use a GBM-on-a-chip to evaluate the anti-GBM effects of nab-PTX/MΦ.Methods: In this study, we constructed nab-PTX/MΦ by incubating live MΦ with nab-PTX. We developed a microfluidic chip to co-culture GBM cells and human umbilical vein endothelial cells, mimicking the simplified blood-brain barrier and GBM. Using a syringe pump, we perform sustainable perfusion of nutrient media. To evaluate the anti-GBM effects nab-PTX/MΦ, we treated the GBM-on-a-chip model with nab-PTX/MΦ and investigated GBM cell proliferation, migration, and spheroid formation.Results: At the chosen concentration, nab-PTX did not significantly affect the viability, chemotaxis and migration of MΦ. The uptake of nab-PTX by MΦ occurred within 1 h of incubation and almost reached saturation at 6 h. Additionally, nab-PTX/MΦ exhibited the M1 phenotype, which inhibits tumor progression. Following phagocytosis, MΦ were able to release nab-PTX, and the release of nab-PTX by MΦ had nearly reached its limit at 48 h. Compared with control group and blank MΦ group, individual nab-PTX group and nab-PTX/MΦ group could inhibit tumor proliferation, invasion and spheroid formation. Meanwhile, the anti-GBM effect of nab-PTX/MΦ was more significant than nab-PTX.Discussion: Our findings demonstrate that nab-PTX/MΦ has a significant anti-GBM effect compared to individual nab-PTX or MΦ administration, suggesting MΦ as potential drug delivery vectors for GBM therapy. Furthermore, the developed GBM-on-a-chip model provides a potential ex vivo platform for innovative cell-based therapies and tailored therapeutic strategies for GBM

Trafficking-Deficient G572R-hERG and E637K-hERG Activate Stress and Clearance Pathways in Endoplasmic Reticulum

Background: Long QT syndrome type 2 (LQT2) is the second most common type of all long QT syndromes. It is well-known that trafficking deficient mutant human ether-a-go-go-related gene (hERG) proteins are often involved in LQT2. Cells respond to misfolded and trafficking-deficient proteins by eliciting the unfolded protein response (UPR) and Activating Transcription Factor (ATF6) has been identified as a key regulator of the mammalian UPR. In this study, we investigated the role of ER chaperone proteins (Calnexin and Calreticulin) in the processing of G572R-hERG and E637K-hERG mutant proteins. Methods: pcDNA3-WT-hERG, pcDNA3-G572R-hERG and pcDNA3-E637K-hERG plasmids were transfected into U2OS and HEK293 cells. Confocal microscopy and western blotting were used to analyze subcellular localization and protein expression. Interaction between WT or mutant hERGs and Calnexin/Calreticulin was tested by coimmunoprecipitation. To assess the role of the ubiquitin proteasome pathway in the degradation of mutant hERG proteins, transfected HEK293 cells were treated with proteasome inhibitors and their effects on the steady state protein levels of WT and mutant hERGs were examined. Conclusion: Our results showed that levels of core-glycosylated immature forms of G572R-hERG and E637K-hERG in association with Calnexin and Calreticulin were higher than that in WT-hERG. Both mutant hERG proteins could activate the UPR by upregulating levels of active ATF6. Furthermore, proteasome inhibition increased the levels of core-glycosylated immature forms of WT and mutant hERGs. In addition, interaction between mutant hERGs and Calnexin/Calreticulin wa

Study on heterogeneous characteristics of methane adsorption by natural coal

In order to find a method for accurately evaluating the methane adsorption capacity of coal with non-uniform potential wells, this paper based on the Langmuir adsorption kinetic process, carried out theoretical analysis and experimental research on the characteristics of methane adsorption by natural coal with non-uniform potential wells, and obtained the following conclusion: in the equilibrium state of coal and methane adsorption, the methane molecules in coal tend to be adsorbed on the deeper adsorption sites of the potential well, and the coverage of potential wells at different depths conforms to the Logistic(S-type) curve law with adsorption pressure and temperature as parameters. The Langmuir parameter a of natural coal samples all increase with the increase of adsorption pressure, and the Langmuir parameter b decreases with the increase of adsorption pressure. The difference in the distribution of the adsorption potential wells of different types of natural coal samples leads to the different Langmuir parameters a and b under different adsorption pressures. The calculated value of methane adsorption in natural coal based on the Langmuir equation is higher at low adsorption pressure, and lower at high adsorption pressure. The calculation method of the non-uniform potential well isotherm adsorption capacity can greatly reduce the calculation error of the methane adsorption capacity in coal

SOLE: Speculative one-cycle load execution with scalability, high-performance and energy-efficiency

Conventional superscalar processors usually contain large CAM-based LSQ (load/store queue) with poor scalability and high energy consumption. Recently proposals only focus on improving the LSQ scalability to increase the in-flight instruction capacity, but with poor performance improvement and energy efficiency. This paper presents a novel speculative store-load forwarding mechanism, named SOLE (speculative one-cycle load execution)(1). Firstly, SOLE uses address identifiers to determine the memory disambiguation, rather than the exact memory addresses as the traditional LSQ does. Since the address identifier is just simple hash from the address base and offset, the speculative store-load forwarding could be advanced earlier to reduce the load execution latency and avoid unnecessary energy consumption by filtering unnecessary accesses to the data cache. Secondly, SOLE enlarges the forwarding communication range by using SSN (store sequential number) to determine the age order between stores, which further improves the performance. Finally, the implementation of SOLE all uses set-associative structures that avoid the non-scalable problem of CAM-based LSQ. Experiments show that performance of SOLE outperforms the traditional LSQ by 13.57% in terms of performance, with only 75.2% execution energy consumption of the loads and stores.Computer Science, Hardware & ArchitectureEngineering, Electrical & ElectronicCPCI-S(ISTP)

S/DC: A storage and energy efficient data prefetcher

Energy efficiency is becoming a major constraint in processor designs. Every component of the processor should be reconsidered to reduce wasted energy and area. Prefetching is an important technique for tolerating memory latency. Prefetcher designs have important impact on the energy efficiency of the memory hierarchy. Stride prefetchers require little storage, but cannot handle irregular access patterns. Delta correlation (DC) prefetchers can handle complicated access patterns, but waste storage because of storing multiple miss addresses for a stride pattern. Moreover, DC prefetchers waste the bandwidth and energy of the memory hierarchy because they cannot identify whether an address has been prefetched and generate a large number of redundant prefetches. In this paper, we propose a storage and energy efficient data prefetcher called stride/DC (S/DC) to combine the advantages of stride and DC prefetchers. S/DC uses a pattern prediction table (PPT) which stores two recent miss addresses in each entry to capture stride patterns. PPT avoids recording multiple miss addresses for a stride pattern, and thus improves the storage efficiency. When handling stride patterns, each PPT entry maintains a counter for obtaining the last prefetched address to avoid generating redundant prefetches. When handling other patterns, S/DC compares the new predicted address with earlier generated addresses in the prefetch queue and filters the redundant ones. In addition, to expand the filtering scope, S/DC uses a prefetch filter to store addresses evicted from the prefetch queue. In this way, S/DC reduces the bandwidth requirements and energy consumption of prefetching. Experimental results demonstrate that S/DC achieves comparable performance with only 24% of the storage and reduces 11.46% of the L2 cache energy, as compared to the CZone/DC prefetcher. ? 2012 EDAA.EI

Wave-Particle Duality Relation with a Quantum Which-Path Detector

According to the relevant theories on duality relation, the summation of the extractable information of a quanton’s wave and particle properties, which are characterized by interference visibility V and path distinguishability D, respectively, is limited. However, this relation is violated upon quantum superposition between the wave-state and particle-state of the quanton, which is caused by the quantum beamsplitter (QBS). Along another line, recent studies have considered quantum coherence C in the l1-norm measure as a candidate for the wave property. In this study, we propose an interferometer with a quantum which-path detector (QWPD) and examine the generalized duality relation based on C. We find that this relationship still holds under such a circumstance, but the interference between these two properties causes the full-particle property to be observed when the QWPD system is partially present. Using a pair of polarization-entangled photons, we experimentally verify our analysis in the two-path case. This study extends the duality relation between coherence and path information to the quantum case and reveals the effect of quantum superposition on the duality relation