Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease

Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction

An Analysis Oncrude Oil Price Mutation in View of Zeeman's Catastrophe Machine

AbstractWith the acceleration of internationalmarket integration and the frequent outbreak of international political and economic events, the volatility of oil priceshas continued toincrease in recent years. As the main source of energy, crude oil plays an important role in the development of a country's economy. Therefore, it is meaningful to study the mutation of oil prices. Based on the Zeeman's catastrophe machine, USDX and excess demand are selected as two main factors to construct the catastrophe model, which helps to explain the structural relationship between USDX and excess demand when the crude oil price mutates

catena-Poly[[[bis­(1,10-phenanthroline-κ2 N,N′)manganese(II)]-μ-9,10-dioxo­anthracene-1,5-disulfonato-κ2 O 1:O 5] tetra­hydrate]

The title complex, {[Mn(C14H6O8S2)(C12H8N2)2]·4H2O}n, exhibits a chain-like polymeric structure with 9,10-dioxo­anthracene-1,5-disulfonate anions bridging MnII atoms in a bis-monodentate mode. The unique MnII atom is located on a crystallographic centre of inversion. Four N atoms from two chelating 1,10-phenanthroline ligands and two sulfonate O atoms from two symmetry-related 9,10-dioxoanthracene-1,5-disulfonate anions give rise to a slightly distorted octa­hedral coordination environment around the MnII centre. The centroid of the central ring of the anthraquinone ligand represents another crystallographic centre of inversion. In the crystal structure, inter­ligand π–π stacking [centroid-to-centroid distances 3.532 (1) and 3.497 (3) Å] and inter­molecular O—H⋯O hydrogen-bonding inter­actions assemble the chains into a three-dimensional supra­molecular network

Interplay between Quantum Size Effect and Strain Effect on Growth of Nanoscale Metal Thin Film

We develop a theoretical framework to investigate the interplay between quantum size effect (QSE) and strain effect on the stability of metal nanofilms. The QSE and strain effect are shown to be coupled through the concept of "quantum electronic stress. First-principles calculations reveal large quantum oscillations in the surface stress of metal nanofilms as a function of film thickness. This adds extrinsically additional strain-coupled quantum oscillations to surface energy of strained metal nanofilms. Our theory enables a quantitative estimation of the amount of strain in experimental samples, and suggests strain be an important factor contributing to the discrepancies between the existing theories and experiments